Structure, Functions, and Implications of Selected Lipocalins in Human Disease
The lipocalin proteins are a large family of small extracellular proteins that demonstrate significant heterogeneity in sequence similarity and have highly conserved crystal structures. They have a variety of functions, including acting as carrier proteins, transporting retinol, participating in olf...
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| Veröffentlicht in: | International journal of molecular sciences 2024-04, Vol.25 (8), p.4290 |
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| creator | Chandrasekaran, Preethi Weiskirchen, Sabine Weiskirchen, Ralf |
| description | The lipocalin proteins are a large family of small extracellular proteins that demonstrate significant heterogeneity in sequence similarity and have highly conserved crystal structures. They have a variety of functions, including acting as carrier proteins, transporting retinol, participating in olfaction, and synthesizing prostaglandins. Importantly, they also play a critical role in human diseases, including cancer. Additionally, they are involved in regulating cellular homeostasis and immune response and dispensing various compounds. This comprehensive review provides information on the lipocalin family, including their structure, functions, and implications in various diseases. It focuses on selective important human lipocalin proteins, such as lipocalin 2 (LCN2), retinol binding protein 4 (RBP4), prostaglandin D2 synthase (PTGDS), and α
-microglobulin (A1M). |
| doi_str_mv | 10.3390/ijms25084290 |
| format | Article |
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| subjects | Amino acids Animals Antioxidants Apolipoproteins Binding sites Biomarkers Disease Exocrine glands Genes Glycoproteins Humans Immune system Intramolecular Oxidoreductases Ligands Lipids Lipocalins - chemistry Lipocalins - genetics Lipocalins - metabolism Neoplasms - metabolism Polypeptides Proteins Retinoids Structure-Activity Relationship Type 2 diabetes |
| title | Structure, Functions, and Implications of Selected Lipocalins in Human Disease |
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