The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas

Medulloblastoma (MB) encompasses diverse subgroups, and leptomeningeal disease/metastasis (LMD) plays a substantial role in associated fatalities. Despite extensive exploration of canonical genes in MB, the molecular mechanisms underlying LMD and the involvement of the orthodenticle homeobox 2 (OTX2...

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Veröffentlicht in:	International journal of molecular sciences 2024-04, Vol.25 (8), p.4416
Hauptverfasser:	Ampudia-Mesias, Elisabet, Cameron, Charles S, Yoo, Eunjae, Kelly, Marcus, Anderson, Sarah M, Manning, Riley, Abrahante Lloréns, Juan E, Moertel, Christopher L, Yim, Hyungshin, Odde, David J, Saydam, Nurten, Saydam, Okay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain cancer Brain research Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cerebellar Neoplasms - genetics Cerebellar Neoplasms - metabolism Cerebellar Neoplasms - pathology Female Gene Expression Regulation, Neoplastic Genes Genomics Humans Kinases Male Mechanistic Target of Rapamycin Complex 2 - genetics Mechanistic Target of Rapamycin Complex 2 - metabolism Medical prognosis Medulloblastoma - genetics Medulloblastoma - metabolism Medulloblastoma - pathology Meningeal Neoplasms - genetics Meningeal Neoplasms - metabolism Meningeal Neoplasms - pathology Meningeal Neoplasms - secondary Metastasis Mice Motility Mutation Otx Transcription Factors - genetics Otx Transcription Factors - metabolism Signal Transduction Tumors
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