A Pipeline for Evaluation of Machine Learning/Artificial Intelligence Models to Quantify Programmed Death Ligand 1 Immunohistochemistry

Immunohistochemistry (IHC) is used to guide treatment decisions in multiple cancer types. For treatment with checkpoint inhibitors, programmed death ligand 1 (PD-L1) IHC is used as a companion diagnostic. However, the scoring of PD-L1 is complicated by its expression in cancer and immune cells. Sepa...

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Veröffentlicht in:	Laboratory investigation 2024-06, Vol.104 (6), p.102070, Article 102070
Hauptverfasser:	Knudsen, Beatrice S., Jadhav, Alok, Perry, Lindsey J., Thagaard, Jeppe, Deftereos, Georgios, Ying, Jian, Brintz, Ben J., Zhang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial Intelligence B7-H1 Antigen - analysis B7-H1 Antigen - metabolism Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism cancer segmentation digital pathology Humans Immunohistochemistry - methods Lung Neoplasms - metabolism Lung Neoplasms - pathology Machine Learning programmed death ligand 1 tumor proportion scores
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