Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study
Objective To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants. Study design Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echoca...
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creator | Terroba-Seara, Sandra Oulego-Erroz, Ignacio Palanca-Arias, Daniel Galve-Pradel, Zenaida Delgado-Nicolás, Sara Pérez-Pérez, Alicia Rodríguez-Ozcoidi, Jorge Lavilla-Oíz, Ana Bravo, María Carmen La Banda-Montalvo, Leticia Méndez-Abad, Paula Zafra-Rodríguez, Pamela Rodeño-Fernández, Lorena Montero-Gato, Jon Bustamante-Hervás, Carmen Vega-Del-Val, Cristina Rodríguez-Fanjul, Javier Mayordomo-Colunga, Juan Alegría-Echauri, Iosune Pérez-Álvarez, Andrea |
description | Objective
To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants.
Study design
Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting.
Results
Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133–0.611);
p
= 0.001].
Conclusions
Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants. |
doi_str_mv | 10.1038/s41372-024-01968-6 |
format | Article |
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To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants.
Study design
Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting.
Results
Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133–0.611);
p
= 0.001].
Conclusions
Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-024-01968-6</identifier><identifier>PMID: 38664495</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/699/375/1345 ; Blood flow ; Echocardiography ; Exposure ; Gestational age ; Hemorrhage ; Infants ; Medicine ; Medicine & Public Health ; Neonates ; Newborn babies ; Pediatric Surgery ; Pediatrics ; Premature babies</subject><ispartof>Journal of perinatology, 2024-10, Vol.44 (10), p.1496-1503</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-cf0268cd912abfb94a0813b35d8d4df69e80a668dfafa898b463e2290e627dc33</cites><orcidid>0000-0002-0128-4215 ; 0000-0001-6327-3047 ; 0000-0002-9653-954X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-024-01968-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-024-01968-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38664495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terroba-Seara, Sandra</creatorcontrib><creatorcontrib>Oulego-Erroz, Ignacio</creatorcontrib><creatorcontrib>Palanca-Arias, Daniel</creatorcontrib><creatorcontrib>Galve-Pradel, Zenaida</creatorcontrib><creatorcontrib>Delgado-Nicolás, Sara</creatorcontrib><creatorcontrib>Pérez-Pérez, Alicia</creatorcontrib><creatorcontrib>Rodríguez-Ozcoidi, Jorge</creatorcontrib><creatorcontrib>Lavilla-Oíz, Ana</creatorcontrib><creatorcontrib>Bravo, María Carmen</creatorcontrib><creatorcontrib>La Banda-Montalvo, Leticia</creatorcontrib><creatorcontrib>Méndez-Abad, Paula</creatorcontrib><creatorcontrib>Zafra-Rodríguez, Pamela</creatorcontrib><creatorcontrib>Rodeño-Fernández, Lorena</creatorcontrib><creatorcontrib>Montero-Gato, Jon</creatorcontrib><creatorcontrib>Bustamante-Hervás, Carmen</creatorcontrib><creatorcontrib>Vega-Del-Val, Cristina</creatorcontrib><creatorcontrib>Rodríguez-Fanjul, Javier</creatorcontrib><creatorcontrib>Mayordomo-Colunga, Juan</creatorcontrib><creatorcontrib>Alegría-Echauri, Iosune</creatorcontrib><creatorcontrib>Pérez-Álvarez, Andrea</creatorcontrib><title>Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants.
Study design
Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting.
Results
Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133–0.611);
p
= 0.001].
Conclusions
Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants.</description><subject>692/308/409</subject><subject>692/699/375/1345</subject><subject>Blood flow</subject><subject>Echocardiography</subject><subject>Exposure</subject><subject>Gestational age</subject><subject>Hemorrhage</subject><subject>Infants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature babies</subject><issn>0743-8346</issn><issn>1476-5543</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEUhYnROO3oC7gwJG7clEJBU5S7ycS_ZBI3uiYUXLqYVBXthXJSL-OzStujJi7ccAnnO4ebHEKec_aaM6HfZMlF1zaslQ3jvdKNekB2XHaq2e-leEh2rJOi0UKqC_Ik51vGTmL3mFwIrZSU_X5HflzlnFy0JaaFDlDuABYKFqeNghuTs-hjOqA9jhvNDqsalwNNgU7pjuYtF5ijo8OUkqfh9GYXT-NS0H6Heka3ThbpCHNCHO0BqkaPCAVwrtdgl5LfUkvndSrRVQcgdWlMWGguq9-ekkfBThme3c9L8vX9uy_XH5ubzx8-XV_dNE60qjQusFZp53ve2iEMvbRMczGIvdde-qB60MwqpX2wwepeD1IJaNuegWo774S4JK_OuUdM31bIxcwxO5gmu0BasxFMdr3caykr-vIf9DatuNTtjOCcC9mJ7hTYnimHKWeEYI4YZ4ub4cyc2jPn9kxtz_xqz6hqenEfvQ4z-D-W33VVQJyBXKXlAPj37__E_gSN-6nH</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Terroba-Seara, Sandra</creator><creator>Oulego-Erroz, Ignacio</creator><creator>Palanca-Arias, Daniel</creator><creator>Galve-Pradel, Zenaida</creator><creator>Delgado-Nicolás, Sara</creator><creator>Pérez-Pérez, Alicia</creator><creator>Rodríguez-Ozcoidi, Jorge</creator><creator>Lavilla-Oíz, Ana</creator><creator>Bravo, María Carmen</creator><creator>La Banda-Montalvo, Leticia</creator><creator>Méndez-Abad, Paula</creator><creator>Zafra-Rodríguez, Pamela</creator><creator>Rodeño-Fernández, Lorena</creator><creator>Montero-Gato, Jon</creator><creator>Bustamante-Hervás, Carmen</creator><creator>Vega-Del-Val, Cristina</creator><creator>Rodríguez-Fanjul, Javier</creator><creator>Mayordomo-Colunga, Juan</creator><creator>Alegría-Echauri, Iosune</creator><creator>Pérez-Álvarez, Andrea</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0128-4215</orcidid><orcidid>https://orcid.org/0000-0001-6327-3047</orcidid><orcidid>https://orcid.org/0000-0002-9653-954X</orcidid></search><sort><creationdate>20241001</creationdate><title>Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study</title><author>Terroba-Seara, Sandra ; Oulego-Erroz, Ignacio ; Palanca-Arias, Daniel ; Galve-Pradel, Zenaida ; Delgado-Nicolás, Sara ; Pérez-Pérez, Alicia ; Rodríguez-Ozcoidi, Jorge ; Lavilla-Oíz, Ana ; Bravo, María Carmen ; La Banda-Montalvo, Leticia ; Méndez-Abad, Paula ; Zafra-Rodríguez, Pamela ; Rodeño-Fernández, Lorena ; Montero-Gato, Jon ; Bustamante-Hervás, Carmen ; Vega-Del-Val, Cristina ; Rodríguez-Fanjul, Javier ; Mayordomo-Colunga, Juan ; Alegría-Echauri, Iosune ; Pérez-Álvarez, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-cf0268cd912abfb94a0813b35d8d4df69e80a668dfafa898b463e2290e627dc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/308/409</topic><topic>692/699/375/1345</topic><topic>Blood flow</topic><topic>Echocardiography</topic><topic>Exposure</topic><topic>Gestational age</topic><topic>Hemorrhage</topic><topic>Infants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature babies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terroba-Seara, Sandra</creatorcontrib><creatorcontrib>Oulego-Erroz, Ignacio</creatorcontrib><creatorcontrib>Palanca-Arias, Daniel</creatorcontrib><creatorcontrib>Galve-Pradel, Zenaida</creatorcontrib><creatorcontrib>Delgado-Nicolás, Sara</creatorcontrib><creatorcontrib>Pérez-Pérez, Alicia</creatorcontrib><creatorcontrib>Rodríguez-Ozcoidi, Jorge</creatorcontrib><creatorcontrib>Lavilla-Oíz, Ana</creatorcontrib><creatorcontrib>Bravo, María Carmen</creatorcontrib><creatorcontrib>La Banda-Montalvo, Leticia</creatorcontrib><creatorcontrib>Méndez-Abad, Paula</creatorcontrib><creatorcontrib>Zafra-Rodríguez, Pamela</creatorcontrib><creatorcontrib>Rodeño-Fernández, Lorena</creatorcontrib><creatorcontrib>Montero-Gato, Jon</creatorcontrib><creatorcontrib>Bustamante-Hervás, Carmen</creatorcontrib><creatorcontrib>Vega-Del-Val, Cristina</creatorcontrib><creatorcontrib>Rodríguez-Fanjul, Javier</creatorcontrib><creatorcontrib>Mayordomo-Colunga, Juan</creatorcontrib><creatorcontrib>Alegría-Echauri, Iosune</creatorcontrib><creatorcontrib>Pérez-Álvarez, Andrea</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terroba-Seara, Sandra</au><au>Oulego-Erroz, Ignacio</au><au>Palanca-Arias, Daniel</au><au>Galve-Pradel, Zenaida</au><au>Delgado-Nicolás, Sara</au><au>Pérez-Pérez, Alicia</au><au>Rodríguez-Ozcoidi, Jorge</au><au>Lavilla-Oíz, Ana</au><au>Bravo, María Carmen</au><au>La Banda-Montalvo, Leticia</au><au>Méndez-Abad, Paula</au><au>Zafra-Rodríguez, Pamela</au><au>Rodeño-Fernández, Lorena</au><au>Montero-Gato, Jon</au><au>Bustamante-Hervás, Carmen</au><au>Vega-Del-Val, Cristina</au><au>Rodríguez-Fanjul, Javier</au><au>Mayordomo-Colunga, Juan</au><au>Alegría-Echauri, Iosune</au><au>Pérez-Álvarez, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>44</volume><issue>10</issue><spage>1496</spage><epage>1503</epage><pages>1496-1503</pages><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>Objective
To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants.
Study design
Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting.
Results
Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133–0.611);
p
= 0.001].
Conclusions
Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38664495</pmid><doi>10.1038/s41372-024-01968-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0128-4215</orcidid><orcidid>https://orcid.org/0000-0001-6327-3047</orcidid><orcidid>https://orcid.org/0000-0002-9653-954X</orcidid></addata></record> |
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subjects | 692/308/409 692/699/375/1345 Blood flow Echocardiography Exposure Gestational age Hemorrhage Infants Medicine Medicine & Public Health Neonates Newborn babies Pediatric Surgery Pediatrics Premature babies |
title | Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study |
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