iMPAQT reveals that adequate mitohormesis from TFAM overexpression leads to life extension in mice

Mitochondrial transcription factor A, TFAM, is essential for mitochondrial function. We examined the effects of overexpressing the gene in mice. Two types of transgenic mice were created: heterozygous ( Tg) and homozygous ( Tg/Tg) mice. Tg/Tg mice were smaller and leaner notably with longer lifespan...

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Veröffentlicht in:	Life science alliance 2024-07, Vol.7 (7), p.e202302498
Hauptverfasser:	Igami, Ko, Kittaka, Hiroki, Yagi, Mikako, Gotoh, Kazuhito, Matsushima, Yuichi, Ide, Tomomi, Ikeda, Masataka, Ueda, Saori, Nitta, Shin-Ichiro, Hayakawa, Manami, Nakayama, Keiichi I, Matsumoto, Masaki, Kang, Dongchon, Uchiumi, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation Growth Differentiation Factor 15 - genetics Growth Differentiation Factor 15 - metabolism High Mobility Group Proteins Longevity - genetics Male Metabolomics - methods Mice Mice, Transgenic Mitochondria - genetics Mitochondria - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Muscle, Skeletal - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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