Designing multitarget ligands for neurodegenerative diseases with improved permeability trough PLGA nanoencapsulation

Multitarget ligands (MTLs) have emerged as an interesting alternative for addressing complex multifactorial pathologies such as neurodegenerative diseases. However, a common challenge associated with these compounds is often their high molecular weight and low solubility, which becomes a hurdle when...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-06, Vol.175, p.116626, Article 116626
Hauptverfasser:	Nozal, Vanesa, Fernández-Gómez, Paula, García-Rubia, Alfonso, Martínez-González, Loreto, Cuevas, Eva P., Carro, Eva, Palomo, Valle, Martínez, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyotrophic lateral sclerosis Blood-brain barrier Multitarget ligand Nanoparticles Protein kinase inhibitors
Online-Zugang:	Volltext
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