Inflammation-Responsive Hydrogel Accelerates Diabetic Wound Healing through Immunoregulation and Enhanced Angiogenesis
Angiogenesis is a prominent component during the highly regulated process of wound healing. The application of exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness is often curtailed due to chronic inflammation...
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| Veröffentlicht in: | Advanced healthcare materials 2024-05, p.e2400150-e2400150 |
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| creator | He, Fang Xu, Pengqin Zhu, Zhikang Zhang, Ying Cai, Chenghao Zhang, Yuxiang Shao, Jiaming Jin, Fang Li, Qiong You, Jiahuan Zhou, Hanlei Zhang, Wei Wei, Jintao Hong, Xudong Zhang, Zhongtao Han, Chunmao Zhang, Yuqi Gu, Zhen Wang, Xingang |
| description | Angiogenesis is a prominent component during the highly regulated process of wound healing. The application of exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness is often curtailed due to chronic inflammation and severe oxidative stress in diabetic wounds. Herein, an inflammation-responsive hydrogel incorporating Prussian blue nanoparticles (PBNPs) is designed to augment the angiogenic efficacy of VEGF. Specifically, the rapid release of PBNPs from the hydrogel under inflammatory conditions effectively alleviates the oxidative stress of the wound, therefore reprogramming the immune microenvironment to preserve the bioactivity of VEGF for enhanced angiogenesis. In vitro and in vivo studies reveal that the PBNPs and VEGF co-loaded hydrogel is biocompatible and possesses effective anti-inflammatory properties, thereby facilitating angiogenesis to accelerate the wound healing process in a type 2 diabetic mouse model. |
| doi_str_mv | 10.1002/adhm.202400150 |
| format | Article |
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The application of exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness is often curtailed due to chronic inflammation and severe oxidative stress in diabetic wounds. Herein, an inflammation-responsive hydrogel incorporating Prussian blue nanoparticles (PBNPs) is designed to augment the angiogenic efficacy of VEGF. Specifically, the rapid release of PBNPs from the hydrogel under inflammatory conditions effectively alleviates the oxidative stress of the wound, therefore reprogramming the immune microenvironment to preserve the bioactivity of VEGF for enhanced angiogenesis. In vitro and in vivo studies reveal that the PBNPs and VEGF co-loaded hydrogel is biocompatible and possesses effective anti-inflammatory properties, thereby facilitating angiogenesis to accelerate the wound healing process in a type 2 diabetic mouse model.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202400150</identifier><identifier>PMID: 38663034</identifier><language>eng</language><publisher>Germany</publisher><ispartof>Advanced healthcare materials, 2024-05, p.e2400150-e2400150</ispartof><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c295t-ead56e4c5a96b6c7fa934c9d8c7dda4fc82ef1c600245e36610986b6106ddd1c3</citedby><cites>FETCH-LOGICAL-c295t-ead56e4c5a96b6c7fa934c9d8c7dda4fc82ef1c600245e36610986b6106ddd1c3</cites><orcidid>0000-0003-2947-4456</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38663034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Fang</creatorcontrib><creatorcontrib>Xu, Pengqin</creatorcontrib><creatorcontrib>Zhu, Zhikang</creatorcontrib><creatorcontrib>Zhang, Ying</creatorcontrib><creatorcontrib>Cai, Chenghao</creatorcontrib><creatorcontrib>Zhang, Yuxiang</creatorcontrib><creatorcontrib>Shao, Jiaming</creatorcontrib><creatorcontrib>Jin, Fang</creatorcontrib><creatorcontrib>Li, Qiong</creatorcontrib><creatorcontrib>You, Jiahuan</creatorcontrib><creatorcontrib>Zhou, Hanlei</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Wei, Jintao</creatorcontrib><creatorcontrib>Hong, Xudong</creatorcontrib><creatorcontrib>Zhang, Zhongtao</creatorcontrib><creatorcontrib>Han, Chunmao</creatorcontrib><creatorcontrib>Zhang, Yuqi</creatorcontrib><creatorcontrib>Gu, Zhen</creatorcontrib><creatorcontrib>Wang, Xingang</creatorcontrib><title>Inflammation-Responsive Hydrogel Accelerates Diabetic Wound Healing through Immunoregulation and Enhanced Angiogenesis</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Angiogenesis is a prominent component during the highly regulated process of wound healing. The application of exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness is often curtailed due to chronic inflammation and severe oxidative stress in diabetic wounds. Herein, an inflammation-responsive hydrogel incorporating Prussian blue nanoparticles (PBNPs) is designed to augment the angiogenic efficacy of VEGF. Specifically, the rapid release of PBNPs from the hydrogel under inflammatory conditions effectively alleviates the oxidative stress of the wound, therefore reprogramming the immune microenvironment to preserve the bioactivity of VEGF for enhanced angiogenesis. 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| title | Inflammation-Responsive Hydrogel Accelerates Diabetic Wound Healing through Immunoregulation and Enhanced Angiogenesis |
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