Growth differentiation factor-15 and metabolic features in chronic heart failure: Insights from the SUPPORT Trial -GDF15 across the BMI spectrum

Growth differentiation factor-15 and metabolic features in chronic heart failure: Insights from the SUPPORT Trial -GDF15 across the BMI spectrum

GDF15 plays pivotal metabolic roles in nutritional stress and serves as a physiological regulator of energy balance. However, the patterns of GDF15 levels in underweight or obese patients with chronic heart failure (CHF) are not well-understood. We assessed serum GDF15 levels at baseline and 3 years...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of cardiology 2024-07, Vol.407, p.132093-132093, Article 132093
Hauptverfasser: Teramoto, Kanako, Nochioka, Kotaro, Sakata, Yasuhiko, Kato, Eri Toda, Nishimura, Kunihiro, Shimokawa, Hiroaki, Yasuda, Satoshi
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomarkers - blood
Body Mass Index
Cachexia
Chronic Disease
Chronic heart failure
Female
Follow-Up Studies
Growth Differentiation Factor 15 - blood
Growth differentiation factor-15
Heart Failure - blood
Heart Failure - epidemiology
Humans
Male
Middle Aged
Obesity
Obesity - blood
Obesity - epidemiology
Thinness - blood
Thinness - epidemiology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:GDF15 plays pivotal metabolic roles in nutritional stress and serves as a physiological regulator of energy balance. However, the patterns of GDF15 levels in underweight or obese patients with chronic heart failure (CHF) are not well-understood. We assessed serum GDF15 levels at baseline and 3 years and the temporal changes in 940 Japanese patients (642 paired samples), as a sub-analysis of the SUPPORT trial (age 65.9 ± 10.1 years). The GDF15 levels were analyzed across BMI groups (underweight [
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2024.132093