The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses
Incorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves wou...
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| creator | Novakoski, Pablo Vinicius de Vitt, Maksuel Gatto Molosse, Vitor Luiz Xavier, Ana Carolina Hadlich Wagner, Roger Klein, Bruna Milarch, Carine Freitas Leonardi, Luiz Eduardo Kozloski, Gilberto Vilmar Vedovatto, Marcelo da Silva, Aleksandro S. |
| description | Incorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65.1 mg/kg of dry matter (DM) Curcumin (74% purity) for an experimental period of 90 days. Blood samples were collected on days 0, 15, 45, and 90. Serum levels of total protein and globulins were higher in the GTRA group (
P
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| doi_str_mv | 10.1007/s11250-024-03993-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3046517019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153605550</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-64e7b12b85e839db3db724e3a365cb0967fc1444ebce65632baaa4d982838eae3</originalsourceid><addsrcrecordid>eNqFkc1uFSEYhomxscfqDbgwJG5cdCoMPwPuTONf0sRNXU8Y-OZIMwNHYFp7C161jFM16aKuSHif9yHhRegFJWeUkO5NprQVpCEtbwjTmjX0EdpR0bGm40w9RjtCuG54x7tj9DTnK0JqTckn6JgpKVui2h36efkNsHHOFx8DjiO2S7LL7AMuEZeaOQ9lvT_EXJobMMGHPXbGp1tszXQN-S2GcQRbMq6CtFbNhEdIM4RiVusp9vO8hDjFva-VU2yCw_GHdzW9BpwgH2LIkJ-ho9FMGZ7fnSfo64f3l-efmosvHz-fv7toLBO6NJJDN9B2UAIU025gbuhaDswwKexAtOxGSznnMFiQQrJ2MMZwp1WrmAID7AS93ryHFL8vkEs_-2xhmkyAuOSeUcEkEUKQ_6OES0E7QnVFX91Dr-KS6l9sFFWa61XYbpRNMecEY39IfjbptqekX0ftt1H7Omr_e9Se1tLLO_UyzOD-Vv6sWAG2AblGYQ_p39sPaH8BR2euGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3046189490</pqid></control><display><type>article</type><title>The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Novakoski, Pablo Vinicius ; de Vitt, Maksuel Gatto ; Molosse, Vitor Luiz ; Xavier, Ana Carolina Hadlich ; Wagner, Roger ; Klein, Bruna ; Milarch, Carine Freitas ; Leonardi, Luiz Eduardo ; Kozloski, Gilberto Vilmar ; Vedovatto, Marcelo ; da Silva, Aleksandro S.</creator><creatorcontrib>Novakoski, Pablo Vinicius ; de Vitt, Maksuel Gatto ; Molosse, Vitor Luiz ; Xavier, Ana Carolina Hadlich ; Wagner, Roger ; Klein, Bruna ; Milarch, Carine Freitas ; Leonardi, Luiz Eduardo ; Kozloski, Gilberto Vilmar ; Vedovatto, Marcelo ; da Silva, Aleksandro S.</creatorcontrib><description><![CDATA[Incorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65.1 mg/kg of dry matter (DM) Curcumin (74% purity) for an experimental period of 90 days. Blood samples were collected on days 0, 15, 45, and 90. Serum levels of total protein and globulins were higher in the GTRA group (
P
< 0.05) than the GCON group. In the GTRA group, there was a reduction in pro-inflammatory cytokines (IL-1ß and IL-6) (
P
< 0.05) and an increase in IL-10 (which acts on anti-inflammatory responses) (
P
< 0.05) when compared to the GCON. There was a significantly higher (
P
< 0.05) concentration of immunoglobulin A (IgA) in the serum of the GTRA than the GCON. A Treatment × Day interaction was observed for haptoglobin levels, which were higher on day 90 in animals that consumed Curcumin than the GCON (
P
< 0.05). The catalase and superoxide dismutase activities were significantly higher (
P
< 0.05) in GTRA, reducing lipid peroxidation when compared to the GCONT. Hematologic variables did not differ significantly between groups. Among the metabolic variables, only urea was higher in the GTRA group when compared to the GCON. Body weight and feed efficiency did not differ between groups (meaning the percentage of apparent digestibility of dry matter, crude protein, and acid detergent fiber (ADF) and neutral detergent fiber (NDF). There was a tendency (
P
= 0.09) for treatment effect and a treatment x day interaction (
P
= 0.05) for levels of short-chain fatty acids in rumen fluid, being lower in animals that consumed curcumin. There was a treatment vs. day interaction (
P
< 0.05) for the concentration of acetate in the rumen fluid (i.e., on day 45, had a reduction in acetate; on day 90, values were higher in the GTRA group when compared to the GCON). We conclude that there was no evidence in the results from this preliminary trial that Curcumin in the diet of dairy calves interfered with feed digestibility. Curcumin may have potential antioxidant, anti-inflammatory, and immune effects that may be desirable for the production system of dairy calves.]]></description><identifier>ISSN: 0049-4747</identifier><identifier>EISSN: 1573-7438</identifier><identifier>DOI: 10.1007/s11250-024-03993-1</identifier><identifier>PMID: 38662082</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>acetates ; Acetic acid ; acid detergent fiber ; Animal Feed - analysis ; Animal health ; Animal Nutritional Physiological Phenomena - drug effects ; Animals ; antioxidant activity ; Antioxidants ; Antioxidants - metabolism ; Biomedical and Life Sciences ; blood serum ; Body weight ; Calves ; Catalase ; Cattle ; crude protein ; Curcumin ; Curcumin - administration & dosage ; Curcumin - pharmacology ; Cytokines ; Cytokines - metabolism ; Diet ; Diet - veterinary ; Dietary Supplements - analysis ; Digestibility ; Dry matter ; Feed conversion ; Feed efficiency ; Female ; Fermentation ; Globulins ; Haptoglobin ; haptoglobins ; Hematology ; Herbal medicine ; Immunoglobulin A ; Immunology ; Inflammation ; interleukin-10 ; interleukin-6 ; Jersey ; Life Sciences ; Lipid peroxidation ; Lipids ; Male ; metabolism ; Microorganisms ; neutral detergent fiber ; Oxidative metabolism ; Oxidative Stress - drug effects ; Peroxidation ; Proteins ; Rumen ; Rumen - drug effects ; Rumen - metabolism ; rumen fermentation ; Serum levels ; Short Communications ; Superoxide dismutase ; Urea ; Veterinary Medicine/Veterinary Science ; Weaning ; Zoology</subject><ispartof>Tropical animal health and production, 2024-05, Vol.56 (4), p.142-142, Article 142</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-64e7b12b85e839db3db724e3a365cb0967fc1444ebce65632baaa4d982838eae3</cites><orcidid>0000-0002-6940-6776</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11250-024-03993-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11250-024-03993-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38662082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Novakoski, Pablo Vinicius</creatorcontrib><creatorcontrib>de Vitt, Maksuel Gatto</creatorcontrib><creatorcontrib>Molosse, Vitor Luiz</creatorcontrib><creatorcontrib>Xavier, Ana Carolina Hadlich</creatorcontrib><creatorcontrib>Wagner, Roger</creatorcontrib><creatorcontrib>Klein, Bruna</creatorcontrib><creatorcontrib>Milarch, Carine Freitas</creatorcontrib><creatorcontrib>Leonardi, Luiz Eduardo</creatorcontrib><creatorcontrib>Kozloski, Gilberto Vilmar</creatorcontrib><creatorcontrib>Vedovatto, Marcelo</creatorcontrib><creatorcontrib>da Silva, Aleksandro S.</creatorcontrib><title>The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses</title><title>Tropical animal health and production</title><addtitle>Trop Anim Health Prod</addtitle><addtitle>Trop Anim Health Prod</addtitle><description><![CDATA[Incorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65.1 mg/kg of dry matter (DM) Curcumin (74% purity) for an experimental period of 90 days. Blood samples were collected on days 0, 15, 45, and 90. Serum levels of total protein and globulins were higher in the GTRA group (
P
< 0.05) than the GCON group. In the GTRA group, there was a reduction in pro-inflammatory cytokines (IL-1ß and IL-6) (
P
< 0.05) and an increase in IL-10 (which acts on anti-inflammatory responses) (
P
< 0.05) when compared to the GCON. There was a significantly higher (
P
< 0.05) concentration of immunoglobulin A (IgA) in the serum of the GTRA than the GCON. A Treatment × Day interaction was observed for haptoglobin levels, which were higher on day 90 in animals that consumed Curcumin than the GCON (
P
< 0.05). The catalase and superoxide dismutase activities were significantly higher (
P
< 0.05) in GTRA, reducing lipid peroxidation when compared to the GCONT. Hematologic variables did not differ significantly between groups. Among the metabolic variables, only urea was higher in the GTRA group when compared to the GCON. Body weight and feed efficiency did not differ between groups (meaning the percentage of apparent digestibility of dry matter, crude protein, and acid detergent fiber (ADF) and neutral detergent fiber (NDF). There was a tendency (
P
= 0.09) for treatment effect and a treatment x day interaction (
P
= 0.05) for levels of short-chain fatty acids in rumen fluid, being lower in animals that consumed curcumin. There was a treatment vs. day interaction (
P
< 0.05) for the concentration of acetate in the rumen fluid (i.e., on day 45, had a reduction in acetate; on day 90, values were higher in the GTRA group when compared to the GCON). We conclude that there was no evidence in the results from this preliminary trial that Curcumin in the diet of dairy calves interfered with feed digestibility. Curcumin may have potential antioxidant, anti-inflammatory, and immune effects that may be desirable for the production system of dairy calves.]]></description><subject>acetates</subject><subject>Acetic acid</subject><subject>acid detergent fiber</subject><subject>Animal Feed - analysis</subject><subject>Animal health</subject><subject>Animal Nutritional Physiological Phenomena - drug effects</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>blood serum</subject><subject>Body weight</subject><subject>Calves</subject><subject>Catalase</subject><subject>Cattle</subject><subject>crude protein</subject><subject>Curcumin</subject><subject>Curcumin - administration & dosage</subject><subject>Curcumin - pharmacology</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Diet</subject><subject>Diet - veterinary</subject><subject>Dietary Supplements - analysis</subject><subject>Digestibility</subject><subject>Dry matter</subject><subject>Feed conversion</subject><subject>Feed efficiency</subject><subject>Female</subject><subject>Fermentation</subject><subject>Globulins</subject><subject>Haptoglobin</subject><subject>haptoglobins</subject><subject>Hematology</subject><subject>Herbal medicine</subject><subject>Immunoglobulin A</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>interleukin-10</subject><subject>interleukin-6</subject><subject>Jersey</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Male</subject><subject>metabolism</subject><subject>Microorganisms</subject><subject>neutral detergent fiber</subject><subject>Oxidative metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Peroxidation</subject><subject>Proteins</subject><subject>Rumen</subject><subject>Rumen - drug effects</subject><subject>Rumen - metabolism</subject><subject>rumen fermentation</subject><subject>Serum levels</subject><subject>Short Communications</subject><subject>Superoxide dismutase</subject><subject>Urea</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Weaning</subject><subject>Zoology</subject><issn>0049-4747</issn><issn>1573-7438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uFSEYhomxscfqDbgwJG5cdCoMPwPuTONf0sRNXU8Y-OZIMwNHYFp7C161jFM16aKuSHif9yHhRegFJWeUkO5NprQVpCEtbwjTmjX0EdpR0bGm40w9RjtCuG54x7tj9DTnK0JqTckn6JgpKVui2h36efkNsHHOFx8DjiO2S7LL7AMuEZeaOQ9lvT_EXJobMMGHPXbGp1tszXQN-S2GcQRbMq6CtFbNhEdIM4RiVusp9vO8hDjFva-VU2yCw_GHdzW9BpwgH2LIkJ-ho9FMGZ7fnSfo64f3l-efmosvHz-fv7toLBO6NJJDN9B2UAIU025gbuhaDswwKexAtOxGSznnMFiQQrJ2MMZwp1WrmAID7AS93ryHFL8vkEs_-2xhmkyAuOSeUcEkEUKQ_6OES0E7QnVFX91Dr-KS6l9sFFWa61XYbpRNMecEY39IfjbptqekX0ftt1H7Omr_e9Se1tLLO_UyzOD-Vv6sWAG2AblGYQ_p39sPaH8BR2euGg</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Novakoski, Pablo Vinicius</creator><creator>de Vitt, Maksuel Gatto</creator><creator>Molosse, Vitor Luiz</creator><creator>Xavier, Ana Carolina Hadlich</creator><creator>Wagner, Roger</creator><creator>Klein, Bruna</creator><creator>Milarch, Carine Freitas</creator><creator>Leonardi, Luiz Eduardo</creator><creator>Kozloski, Gilberto Vilmar</creator><creator>Vedovatto, Marcelo</creator><creator>da Silva, Aleksandro S.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-6940-6776</orcidid></search><sort><creationdate>20240501</creationdate><title>The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses</title><author>Novakoski, Pablo Vinicius ; de Vitt, Maksuel Gatto ; Molosse, Vitor Luiz ; Xavier, Ana Carolina Hadlich ; Wagner, Roger ; Klein, Bruna ; Milarch, Carine Freitas ; Leonardi, Luiz Eduardo ; Kozloski, Gilberto Vilmar ; Vedovatto, Marcelo ; da Silva, Aleksandro S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-64e7b12b85e839db3db724e3a365cb0967fc1444ebce65632baaa4d982838eae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>acetates</topic><topic>Acetic acid</topic><topic>acid detergent fiber</topic><topic>Animal Feed - analysis</topic><topic>Animal health</topic><topic>Animal Nutritional Physiological Phenomena - drug effects</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>blood serum</topic><topic>Body weight</topic><topic>Calves</topic><topic>Catalase</topic><topic>Cattle</topic><topic>crude protein</topic><topic>Curcumin</topic><topic>Curcumin - administration & dosage</topic><topic>Curcumin - pharmacology</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Diet</topic><topic>Diet - veterinary</topic><topic>Dietary Supplements - analysis</topic><topic>Digestibility</topic><topic>Dry matter</topic><topic>Feed conversion</topic><topic>Feed efficiency</topic><topic>Female</topic><topic>Fermentation</topic><topic>Globulins</topic><topic>Haptoglobin</topic><topic>haptoglobins</topic><topic>Hematology</topic><topic>Herbal medicine</topic><topic>Immunoglobulin A</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>interleukin-10</topic><topic>interleukin-6</topic><topic>Jersey</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Male</topic><topic>metabolism</topic><topic>Microorganisms</topic><topic>neutral detergent fiber</topic><topic>Oxidative metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Peroxidation</topic><topic>Proteins</topic><topic>Rumen</topic><topic>Rumen - drug effects</topic><topic>Rumen - metabolism</topic><topic>rumen fermentation</topic><topic>Serum levels</topic><topic>Short Communications</topic><topic>Superoxide dismutase</topic><topic>Urea</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Weaning</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Novakoski, Pablo Vinicius</creatorcontrib><creatorcontrib>de Vitt, Maksuel Gatto</creatorcontrib><creatorcontrib>Molosse, Vitor Luiz</creatorcontrib><creatorcontrib>Xavier, Ana Carolina Hadlich</creatorcontrib><creatorcontrib>Wagner, Roger</creatorcontrib><creatorcontrib>Klein, Bruna</creatorcontrib><creatorcontrib>Milarch, Carine Freitas</creatorcontrib><creatorcontrib>Leonardi, Luiz Eduardo</creatorcontrib><creatorcontrib>Kozloski, Gilberto Vilmar</creatorcontrib><creatorcontrib>Vedovatto, Marcelo</creatorcontrib><creatorcontrib>da Silva, Aleksandro S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Tropical animal health and production</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Novakoski, Pablo Vinicius</au><au>de Vitt, Maksuel Gatto</au><au>Molosse, Vitor Luiz</au><au>Xavier, Ana Carolina Hadlich</au><au>Wagner, Roger</au><au>Klein, Bruna</au><au>Milarch, Carine Freitas</au><au>Leonardi, Luiz Eduardo</au><au>Kozloski, Gilberto Vilmar</au><au>Vedovatto, Marcelo</au><au>da Silva, Aleksandro S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses</atitle><jtitle>Tropical animal health and production</jtitle><stitle>Trop Anim Health Prod</stitle><addtitle>Trop Anim Health Prod</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>56</volume><issue>4</issue><spage>142</spage><epage>142</epage><pages>142-142</pages><artnum>142</artnum><issn>0049-4747</issn><eissn>1573-7438</eissn><abstract><![CDATA[Incorporating Curcumin into animal diets holds significant promise for enhancing both animal health and productivity, with demonstrated positive impacts on antioxidant activity, anti-microbial responses. Therefore, this study aimed to determine whether adding Curcumin to the diet of dairy calves would influence ruminal fermentation, hematologic, immunological, oxidative, and metabolism variables. Fourteen Jersey calves were divided into a control group (GCON) and a treatment group (GTRA). The animals in the GTRA received a diet containing 65.1 mg/kg of dry matter (DM) Curcumin (74% purity) for an experimental period of 90 days. Blood samples were collected on days 0, 15, 45, and 90. Serum levels of total protein and globulins were higher in the GTRA group (
P
< 0.05) than the GCON group. In the GTRA group, there was a reduction in pro-inflammatory cytokines (IL-1ß and IL-6) (
P
< 0.05) and an increase in IL-10 (which acts on anti-inflammatory responses) (
P
< 0.05) when compared to the GCON. There was a significantly higher (
P
< 0.05) concentration of immunoglobulin A (IgA) in the serum of the GTRA than the GCON. A Treatment × Day interaction was observed for haptoglobin levels, which were higher on day 90 in animals that consumed Curcumin than the GCON (
P
< 0.05). The catalase and superoxide dismutase activities were significantly higher (
P
< 0.05) in GTRA, reducing lipid peroxidation when compared to the GCONT. Hematologic variables did not differ significantly between groups. Among the metabolic variables, only urea was higher in the GTRA group when compared to the GCON. Body weight and feed efficiency did not differ between groups (meaning the percentage of apparent digestibility of dry matter, crude protein, and acid detergent fiber (ADF) and neutral detergent fiber (NDF). There was a tendency (
P
= 0.09) for treatment effect and a treatment x day interaction (
P
= 0.05) for levels of short-chain fatty acids in rumen fluid, being lower in animals that consumed curcumin. There was a treatment vs. day interaction (
P
< 0.05) for the concentration of acetate in the rumen fluid (i.e., on day 45, had a reduction in acetate; on day 90, values were higher in the GTRA group when compared to the GCON). We conclude that there was no evidence in the results from this preliminary trial that Curcumin in the diet of dairy calves interfered with feed digestibility. Curcumin may have potential antioxidant, anti-inflammatory, and immune effects that may be desirable for the production system of dairy calves.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38662082</pmid><doi>10.1007/s11250-024-03993-1</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6940-6776</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-4747 |
| ispartof | Tropical animal health and production, 2024-05, Vol.56 (4), p.142-142, Article 142 |
| issn | 0049-4747 1573-7438 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3046517019 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | acetates Acetic acid acid detergent fiber Animal Feed - analysis Animal health Animal Nutritional Physiological Phenomena - drug effects Animals antioxidant activity Antioxidants Antioxidants - metabolism Biomedical and Life Sciences blood serum Body weight Calves Catalase Cattle crude protein Curcumin Curcumin - administration & dosage Curcumin - pharmacology Cytokines Cytokines - metabolism Diet Diet - veterinary Dietary Supplements - analysis Digestibility Dry matter Feed conversion Feed efficiency Female Fermentation Globulins Haptoglobin haptoglobins Hematology Herbal medicine Immunoglobulin A Immunology Inflammation interleukin-10 interleukin-6 Jersey Life Sciences Lipid peroxidation Lipids Male metabolism Microorganisms neutral detergent fiber Oxidative metabolism Oxidative Stress - drug effects Peroxidation Proteins Rumen Rumen - drug effects Rumen - metabolism rumen fermentation Serum levels Short Communications Superoxide dismutase Urea Veterinary Medicine/Veterinary Science Weaning Zoology |
| title | The addition of curcumin to the diet of post-weaning dairy calves: effects on ruminal fermentation, immunological, and oxidative responses |
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