Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment

Sarcopenia is characterized by loss of muscle strength and muscle mass with aging. The growing number of sarcopenia patients as a result of the aging population has no viable treatment. Exercise maintains muscle strength and mass by increasing peroxisome growth factor activating receptor γ-conjugati...

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Veröffentlicht in:	Free radical biology & medicine 2024-08, Vol.220, p.67-77
Hauptverfasser:	Noguchi, Isamu, Maeda, Hitoshi, Kobayashi, Kazuki, Nagasaki, Taisei, Kato, Hiromasa, Yanagisawa, Hiroki, Wada, Naoki, Kanazawa, Gai, Kaji, Tsubasa, Sakai, Hiromi, Fujimaki, Shin, Ono, Yusuke, Taguchi, Kazuaki, Chuang, Victor Tuan Giam, Saruwatari, Junji, Otagiri, Masaki, Watanabe, Hiroshi, Maruyama, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Carbon monoxide Carbon Monoxide - metabolism Carbon Monoxide - pharmacology Cell Line Cell- and Tissue-Based Therapy - methods Disease Models, Animal Exercise mimetic Humans Male Mice Mice, Inbred C57BL Mitochondrial biogenesis Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Myoblasts - drug effects Myoblasts - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC-1α Physical Conditioning, Animal Proto-Oncogene Proteins c-akt - metabolism Sarcopenia Sarcopenia - drug therapy Sarcopenia - metabolism Sarcopenia - pathology Sarcopenia - therapy Signal Transduction - drug effects
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