Evaluation of layer-by-layer assembly systems for drug delivery and antimicrobial properties in orthopaedic application
[Display omitted] Layer-by-layer self-assembly systems were developed using monolayer and multilayer carriers to prevent infections and improve bone regeneration of porous Ti-6Al-4V scaffolds. These polymeric carriers incorporated (Gel/Alg-IGF-1 + Chi-Cef) and (4Gel/Alg-IGF-1 + Chi-Cef) on the surfa...
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| Veröffentlicht in: | International journal of pharmaceutics 2024-05, Vol.657, p.124148, Article 124148 |
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| container_title | International journal of pharmaceutics |
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| creator | Mofazali, Parinaz Atapour, Masoud Nakamura, Miho Galati, Manuela Saboori, Abdollah |
| description | [Display omitted]
Layer-by-layer self-assembly systems were developed using monolayer and multilayer carriers to prevent infections and improve bone regeneration of porous Ti-6Al-4V scaffolds. These polymeric carriers incorporated (Gel/Alg-IGF-1 + Chi-Cef) and (4Gel/Alg-IGF-1 + Chi-Cef) on the surface of porous implants produced via electron beam melting (EBM). The results showed that the drug release from multilayer carriers was higher than that of monolayers after 14 days. However, the carrier containing Gel/Alg-IGF-1 + Chi-Cef exhibited more sustained behavior. Cell morphology was characterized, revealing that multilayer carriers had higher cell adhesion than monolayers. Additionally, cell differentiation was significantly greater for (Gel/Alg-IGF-1) + Chi-Cef, and (4Gel/Alg-IGF-1) + Chi-Cef multilayer carriers than for the monolayer groups after 7 days. Notably, the drug dosage was effective and did not interfere, and the cell viability assay showed safe results. Antibacterial evaluations demonstrated that both multilayer carriers had a greater effect on Staphylococcus aureus during treatment. The carriers containing lower alginate had notably less effect than the other studied carriers. This study aimed to test systems for controlling drug release, which will be applied to improve MG63 cell behavior and prevent bacterial accumulation during orthopaedic applications. |
| doi_str_mv | 10.1016/j.ijpharm.2024.124148 |
| format | Article |
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Layer-by-layer self-assembly systems were developed using monolayer and multilayer carriers to prevent infections and improve bone regeneration of porous Ti-6Al-4V scaffolds. These polymeric carriers incorporated (Gel/Alg-IGF-1 + Chi-Cef) and (4Gel/Alg-IGF-1 + Chi-Cef) on the surface of porous implants produced via electron beam melting (EBM). The results showed that the drug release from multilayer carriers was higher than that of monolayers after 14 days. However, the carrier containing Gel/Alg-IGF-1 + Chi-Cef exhibited more sustained behavior. Cell morphology was characterized, revealing that multilayer carriers had higher cell adhesion than monolayers. Additionally, cell differentiation was significantly greater for (Gel/Alg-IGF-1) + Chi-Cef, and (4Gel/Alg-IGF-1) + Chi-Cef multilayer carriers than for the monolayer groups after 7 days. Notably, the drug dosage was effective and did not interfere, and the cell viability assay showed safe results. Antibacterial evaluations demonstrated that both multilayer carriers had a greater effect on Staphylococcus aureus during treatment. The carriers containing lower alginate had notably less effect than the other studied carriers. This study aimed to test systems for controlling drug release, which will be applied to improve MG63 cell behavior and prevent bacterial accumulation during orthopaedic applications.</description><identifier>ISSN: 0378-5173</identifier><identifier>ISSN: 1873-3476</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2024.124148</identifier><identifier>PMID: 38657718</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alginates - chemistry ; Alloys - chemistry ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Cefazolin ; Cell Adhesion - drug effects ; Cell Differentiation - drug effects ; Cell Line, Tumor ; Cell Survival - drug effects ; Drug Carriers - chemistry ; Drug Delivery Systems ; Drug Liberation ; Drug release ; Electron beam melting ; Humans ; Insulin-like growth factor-1 ; Layer-by-Layer Nanoparticles ; Layer-by-layer self-assembly ; Polymeric carriers ; Porosity ; Staphylococcus aureus - drug effects ; Tissue Scaffolds - chemistry ; Titanium - chemistry</subject><ispartof>International journal of pharmaceutics, 2024-05, Vol.657, p.124148, Article 124148</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c313t-560f3ccc26e6275d533af26a7a8020b0f471195507336c48d99e02f34f40ca8a3</cites><orcidid>0000-0001-6333-0179</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037851732400382X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38657718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mofazali, Parinaz</creatorcontrib><creatorcontrib>Atapour, Masoud</creatorcontrib><creatorcontrib>Nakamura, Miho</creatorcontrib><creatorcontrib>Galati, Manuela</creatorcontrib><creatorcontrib>Saboori, Abdollah</creatorcontrib><title>Evaluation of layer-by-layer assembly systems for drug delivery and antimicrobial properties in orthopaedic application</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Layer-by-layer self-assembly systems were developed using monolayer and multilayer carriers to prevent infections and improve bone regeneration of porous Ti-6Al-4V scaffolds. These polymeric carriers incorporated (Gel/Alg-IGF-1 + Chi-Cef) and (4Gel/Alg-IGF-1 + Chi-Cef) on the surface of porous implants produced via electron beam melting (EBM). The results showed that the drug release from multilayer carriers was higher than that of monolayers after 14 days. However, the carrier containing Gel/Alg-IGF-1 + Chi-Cef exhibited more sustained behavior. Cell morphology was characterized, revealing that multilayer carriers had higher cell adhesion than monolayers. Additionally, cell differentiation was significantly greater for (Gel/Alg-IGF-1) + Chi-Cef, and (4Gel/Alg-IGF-1) + Chi-Cef multilayer carriers than for the monolayer groups after 7 days. Notably, the drug dosage was effective and did not interfere, and the cell viability assay showed safe results. Antibacterial evaluations demonstrated that both multilayer carriers had a greater effect on Staphylococcus aureus during treatment. The carriers containing lower alginate had notably less effect than the other studied carriers. This study aimed to test systems for controlling drug release, which will be applied to improve MG63 cell behavior and prevent bacterial accumulation during orthopaedic applications.</description><subject>Alginates - chemistry</subject><subject>Alloys - chemistry</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Cefazolin</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Drug release</subject><subject>Electron beam melting</subject><subject>Humans</subject><subject>Insulin-like growth factor-1</subject><subject>Layer-by-Layer Nanoparticles</subject><subject>Layer-by-layer self-assembly</subject><subject>Polymeric carriers</subject><subject>Porosity</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Titanium - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq2Kii6FnwDykUuW8Xf2hFBVPqRKXMrZcpxx65WzCXayKP--bnfhymE0c3hn3nkfQt4z2DJg-tN-G_fTo8vDlgOXW8Ylk-0F2bDWiEZIo1-RDQjTNooZcUXelLIHAM2ZeE2uRKuVMazdkD-3R5cWN8fxQMdAk1sxN93avAzUlYJDl1Za1jLjUGgYM-3z8kB7TPGIeaXu0Nea4xB9HrvoEp3yOGGeIxYa69E8P46Twz566qYpRf9i9pZcBpcKvjv3a_Lr6-39zffm7ue3Hzdf7hovmJgbpSEI7z3XqLlRvRLCBa6dcS1w6CBIw9hOKTBCaC_bfrdD4EHIIMG71olr8vF0t371e8Ey2yEWjym5A45LsQKkVkxLgCpVJ2kNUkrGYKccB5dXy8A-M7d7e2Zun5nbE_O69-FssXQD9v-2_kKugs8nAdagx4jZFh_x4CuTjH62_Rj_Y_EEh7OXTA</recordid><startdate>20240525</startdate><enddate>20240525</enddate><creator>Mofazali, Parinaz</creator><creator>Atapour, Masoud</creator><creator>Nakamura, Miho</creator><creator>Galati, Manuela</creator><creator>Saboori, Abdollah</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6333-0179</orcidid></search><sort><creationdate>20240525</creationdate><title>Evaluation of layer-by-layer assembly systems for drug delivery and antimicrobial properties in orthopaedic application</title><author>Mofazali, Parinaz ; Atapour, Masoud ; Nakamura, Miho ; Galati, Manuela ; Saboori, Abdollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-560f3ccc26e6275d533af26a7a8020b0f471195507336c48d99e02f34f40ca8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alginates - chemistry</topic><topic>Alloys - chemistry</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Cefazolin</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Drug Liberation</topic><topic>Drug release</topic><topic>Electron beam melting</topic><topic>Humans</topic><topic>Insulin-like growth factor-1</topic><topic>Layer-by-Layer Nanoparticles</topic><topic>Layer-by-layer self-assembly</topic><topic>Polymeric carriers</topic><topic>Porosity</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mofazali, Parinaz</creatorcontrib><creatorcontrib>Atapour, Masoud</creatorcontrib><creatorcontrib>Nakamura, Miho</creatorcontrib><creatorcontrib>Galati, Manuela</creatorcontrib><creatorcontrib>Saboori, Abdollah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mofazali, Parinaz</au><au>Atapour, Masoud</au><au>Nakamura, Miho</au><au>Galati, Manuela</au><au>Saboori, Abdollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of layer-by-layer assembly systems for drug delivery and antimicrobial properties in orthopaedic application</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2024-05-25</date><risdate>2024</risdate><volume>657</volume><spage>124148</spage><pages>124148-</pages><artnum>124148</artnum><issn>0378-5173</issn><issn>1873-3476</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Layer-by-layer self-assembly systems were developed using monolayer and multilayer carriers to prevent infections and improve bone regeneration of porous Ti-6Al-4V scaffolds. These polymeric carriers incorporated (Gel/Alg-IGF-1 + Chi-Cef) and (4Gel/Alg-IGF-1 + Chi-Cef) on the surface of porous implants produced via electron beam melting (EBM). The results showed that the drug release from multilayer carriers was higher than that of monolayers after 14 days. However, the carrier containing Gel/Alg-IGF-1 + Chi-Cef exhibited more sustained behavior. Cell morphology was characterized, revealing that multilayer carriers had higher cell adhesion than monolayers. Additionally, cell differentiation was significantly greater for (Gel/Alg-IGF-1) + Chi-Cef, and (4Gel/Alg-IGF-1) + Chi-Cef multilayer carriers than for the monolayer groups after 7 days. Notably, the drug dosage was effective and did not interfere, and the cell viability assay showed safe results. Antibacterial evaluations demonstrated that both multilayer carriers had a greater effect on Staphylococcus aureus during treatment. The carriers containing lower alginate had notably less effect than the other studied carriers. This study aimed to test systems for controlling drug release, which will be applied to improve MG63 cell behavior and prevent bacterial accumulation during orthopaedic applications.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38657718</pmid><doi>10.1016/j.ijpharm.2024.124148</doi><orcidid>https://orcid.org/0000-0001-6333-0179</orcidid></addata></record> |
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| subjects | Alginates - chemistry Alloys - chemistry Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Cefazolin Cell Adhesion - drug effects Cell Differentiation - drug effects Cell Line, Tumor Cell Survival - drug effects Drug Carriers - chemistry Drug Delivery Systems Drug Liberation Drug release Electron beam melting Humans Insulin-like growth factor-1 Layer-by-Layer Nanoparticles Layer-by-layer self-assembly Polymeric carriers Porosity Staphylococcus aureus - drug effects Tissue Scaffolds - chemistry Titanium - chemistry |
| title | Evaluation of layer-by-layer assembly systems for drug delivery and antimicrobial properties in orthopaedic application |
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