Prognostic factors associated with failure of modular knee arthroplasty in oncologic patients

reconstruction of large bone defects using modular knee arthroplasty (MKA) presents a significant challenge in terms of functionality. The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. a retrospective cohort study wa...

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Veröffentlicht in:	Acta ortopédica mexicana 2024-01, Vol.38 (1), p.15-21
Hauptverfasser:	Velázquez-Rodríguez, S, Clara-Altamirano, M A, García-Ortega, D Y, Lizcano-Suárez, A R, Martínez-Said, H, Villavicencio-Valencia, V, Cuellar-Hubbe, M
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Schlagworte:	Adolescent Adult Arthroplasty, Replacement, Knee - methods Bone Neoplasms - surgery Female Humans Knee Prosthesis Male Middle Aged Operative Time Prognosis Prosthesis Failure Prosthesis-Related Infections - etiology Retrospective Studies Tibia - surgery Treatment Failure Young Adult
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creator	Velázquez-Rodríguez, S Clara-Altamirano, M A García-Ortega, D Y Lizcano-Suárez, A R Martínez-Said, H Villavicencio-Valencia, V Cuellar-Hubbe, M
description	reconstruction of large bone defects using modular knee arthroplasty (MKA) presents a significant challenge in terms of functionality. The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021. 49 patients were included, of which 25 (51.02%) were women and 24 (48.98%) men, with a mean age of 29.57 years. Of these, 14 (28.57%) patients experienced some type of MKA failure. The most frequent complication that led to failure was periprosthetic infection, observed in seven (14.29%) patients. Variables associated with MKA failure included biopsies performed outside our hospital (HR 3.2, 95% CI 1.4-6.4, p = 0.02), the length of the long axis of the tumor (HR 2.1, 95% CI 1.2-4.6, p = 0.01) and a prolonged surgical time (HR 3.37, 95% CI 1.1-8.6, p = 0.04). the most significant prognostic factors associated with MKA failure in our cohort were tumor size, prolonged surgical time, and performance of the diagnostic biopsy in a center not specialized in the management of this type of patient. These findings highlight the importance of considering these variables to improve outcomes in patients undergoing MKA.
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The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021. 49 patients were included, of which 25 (51.02%) were women and 24 (48.98%) men, with a mean age of 29.57 years. Of these, 14 (28.57%) patients experienced some type of MKA failure. The most frequent complication that led to failure was periprosthetic infection, observed in seven (14.29%) patients. Variables associated with MKA failure included biopsies performed outside our hospital (HR 3.2, 95% CI 1.4-6.4, p = 0.02), the length of the long axis of the tumor (HR 2.1, 95% CI 1.2-4.6, p = 0.01) and a prolonged surgical time (HR 3.37, 95% CI 1.1-8.6, p = 0.04). the most significant prognostic factors associated with MKA failure in our cohort were tumor size, prolonged surgical time, and performance of the diagnostic biopsy in a center not specialized in the management of this type of patient. 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The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021. 49 patients were included, of which 25 (51.02%) were women and 24 (48.98%) men, with a mean age of 29.57 years. Of these, 14 (28.57%) patients experienced some type of MKA failure. The most frequent complication that led to failure was periprosthetic infection, observed in seven (14.29%) patients. Variables associated with MKA failure included biopsies performed outside our hospital (HR 3.2, 95% CI 1.4-6.4, p = 0.02), the length of the long axis of the tumor (HR 2.1, 95% CI 1.2-4.6, p = 0.01) and a prolonged surgical time (HR 3.37, 95% CI 1.1-8.6, p = 0.04). the most significant prognostic factors associated with MKA failure in our cohort were tumor size, prolonged surgical time, and performance of the diagnostic biopsy in a center not specialized in the management of this type of patient. 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The objective of the present work was to identify the different prognostic factors associated with failure of MKA in cancer patients. a retrospective cohort study was conducted, including patients with a diagnosis of musculoskeletal tumor in the distal femur or proximal tibia, who underwent MKA between January 1, 2010, and December 31, 2021. 49 patients were included, of which 25 (51.02%) were women and 24 (48.98%) men, with a mean age of 29.57 years. Of these, 14 (28.57%) patients experienced some type of MKA failure. The most frequent complication that led to failure was periprosthetic infection, observed in seven (14.29%) patients. 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subjects	Adolescent Adult Arthroplasty, Replacement, Knee - methods Bone Neoplasms - surgery Female Humans Knee Prosthesis Male Middle Aged Operative Time Prognosis Prosthesis Failure Prosthesis-Related Infections - etiology Retrospective Studies Tibia - surgery Treatment Failure Young Adult
title	Prognostic factors associated with failure of modular knee arthroplasty in oncologic patients
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