Resistance phenotype and virulence potential of Leclercia adecarboxylata strains isolated from different sources
is a member of Enterobacterales, often considered an opportunistic pathogen. Recent reports have highlighted as an emerging pathogen harbouring virulence and resistance determinants. Little information exists on virulence and resistance determinants in strains isolated from environmental, food, and...
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| Veröffentlicht in: | Microbiology (Society for General Microbiology) 2024-04, Vol.170 (4) |
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| creator | Yescas-Zazueta, Viviana Rocha-Gracia, Rosa Del Carmen González-Bonilla, Cesar R Ayala-Zavala, J Fernando Enciso-Martínez, Yessica Carreón-León, Eder A González Corona, Brigitte A Valencia, Dora Ballesteros-Monrreal, Manuel G Barrios-Villa, Edwin |
| description | is a member of Enterobacterales, often considered an opportunistic pathogen. Recent reports have highlighted
as an emerging pathogen harbouring virulence and resistance determinants.
Little information exists on virulence and resistance determinants in
strains isolated from environmental, food, and clinical samples.
To determine the presence of resistance and virulence determinants and plasmid features in
strains isolated from environmental, food, and clinical samples, as well as their phylogenetic relationship.
All strains tested showed resistance to β-lactams and quinolones but were sensitive to aminoglycosides and nitrofurans. However, even though fosfomycin resistance is considered a characteristic trait of
, the resistance phenotype was only observed in 50 % of the strains;
was the most prevalent BLEE gene (70 %), while the quinolone
gene was observed in 60 % of the strains. Virulence genes were differentially observed in the strains, with adhesion-related genes being the most abundant, followed by toxin genes. Finally, all strains carried one to seven plasmid bands ranging from 7 to 125 kbps and harboured several plasmid addiction systems, such as ParDE, VagCD, and CcdAB in 80 % of the strains.
is an important emerging pathogen that may harbour resistance and virulence genes. Additionally, it has mobilizable genetic elements that may contribute to the dissemination of genetic determinants to other bacterial genera. |
| doi_str_mv | 10.1099/mic.0.001457 |
| format | Article |
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as an emerging pathogen harbouring virulence and resistance determinants.
Little information exists on virulence and resistance determinants in
strains isolated from environmental, food, and clinical samples.
To determine the presence of resistance and virulence determinants and plasmid features in
strains isolated from environmental, food, and clinical samples, as well as their phylogenetic relationship.
All strains tested showed resistance to β-lactams and quinolones but were sensitive to aminoglycosides and nitrofurans. However, even though fosfomycin resistance is considered a characteristic trait of
, the resistance phenotype was only observed in 50 % of the strains;
was the most prevalent BLEE gene (70 %), while the quinolone
gene was observed in 60 % of the strains. Virulence genes were differentially observed in the strains, with adhesion-related genes being the most abundant, followed by toxin genes. Finally, all strains carried one to seven plasmid bands ranging from 7 to 125 kbps and harboured several plasmid addiction systems, such as ParDE, VagCD, and CcdAB in 80 % of the strains.
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as an emerging pathogen harbouring virulence and resistance determinants.
Little information exists on virulence and resistance determinants in
strains isolated from environmental, food, and clinical samples.
To determine the presence of resistance and virulence determinants and plasmid features in
strains isolated from environmental, food, and clinical samples, as well as their phylogenetic relationship.
All strains tested showed resistance to β-lactams and quinolones but were sensitive to aminoglycosides and nitrofurans. However, even though fosfomycin resistance is considered a characteristic trait of
, the resistance phenotype was only observed in 50 % of the strains;
was the most prevalent BLEE gene (70 %), while the quinolone
gene was observed in 60 % of the strains. Virulence genes were differentially observed in the strains, with adhesion-related genes being the most abundant, followed by toxin genes. Finally, all strains carried one to seven plasmid bands ranging from 7 to 125 kbps and harboured several plasmid addiction systems, such as ParDE, VagCD, and CcdAB in 80 % of the strains.
is an important emerging pathogen that may harbour resistance and virulence genes. 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Recent reports have highlighted
as an emerging pathogen harbouring virulence and resistance determinants.
Little information exists on virulence and resistance determinants in
strains isolated from environmental, food, and clinical samples.
To determine the presence of resistance and virulence determinants and plasmid features in
strains isolated from environmental, food, and clinical samples, as well as their phylogenetic relationship.
All strains tested showed resistance to β-lactams and quinolones but were sensitive to aminoglycosides and nitrofurans. However, even though fosfomycin resistance is considered a characteristic trait of
, the resistance phenotype was only observed in 50 % of the strains;
was the most prevalent BLEE gene (70 %), while the quinolone
gene was observed in 60 % of the strains. Virulence genes were differentially observed in the strains, with adhesion-related genes being the most abundant, followed by toxin genes. Finally, all strains carried one to seven plasmid bands ranging from 7 to 125 kbps and harboured several plasmid addiction systems, such as ParDE, VagCD, and CcdAB in 80 % of the strains.
is an important emerging pathogen that may harbour resistance and virulence genes. Additionally, it has mobilizable genetic elements that may contribute to the dissemination of genetic determinants to other bacterial genera.</abstract><cop>England</cop><pmid>38661713</pmid><doi>10.1099/mic.0.001457</doi><orcidid>https://orcid.org/0000-0002-0456-8264</orcidid><orcidid>https://orcid.org/0000-0002-2225-5069</orcidid><orcidid>https://orcid.org/0009-0000-4398-4319</orcidid><orcidid>https://orcid.org/0009-0006-9245-1846</orcidid><orcidid>https://orcid.org/0000-0002-3275-5243</orcidid><orcidid>https://orcid.org/0000-0002-9285-9896</orcidid><orcidid>https://orcid.org/0000-0002-0691-6453</orcidid><orcidid>https://orcid.org/0000-0003-4493-8685</orcidid><orcidid>https://orcid.org/0000-0002-7864-1292</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Anti-Bacterial Agents - pharmacology beta-Lactams - pharmacology Drug Resistance, Bacterial - genetics Drug Resistance, Multiple, Bacterial - genetics Enterobacteriaceae - classification Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Enterobacteriaceae - pathogenicity Enterobacteriaceae Infections - microbiology Food Microbiology Humans Microbial Sensitivity Tests Phenotype Phylogeny Plasmids - genetics Quinolones - pharmacology Virulence - genetics Virulence Factors - genetics |
| title | Resistance phenotype and virulence potential of Leclercia adecarboxylata strains isolated from different sources |
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