Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy
A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two‐photon absorption at 808 nm and remarkable singl...
Gespeichert in:
| Veröffentlicht in: | Angewandte Chemie International Edition 2024-07, Vol.63 (27), p.e202402028-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 27 |
| container_start_page | e202402028 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 63 |
| creator | Li, Xue‐Lian Wang, Meng‐Fan Zeng, Li‐Zhen Li, Guo‐Kui Zhao, Run‐Yu Liu, Fu‐Dan Li, Yun Yan, Yu‐Fei Liu, Qishuai Li, Zhao Zhang, Hongbin Ren, Xiaoxia Gao, Feng |
| description | A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two‐photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nuclei and mitochondria, and regulates DNA‐related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase and RNA polymerase inhibition and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy in vivo for malignant melanoma and cisplatin‐resistant non‐small cell lung cancer tumors, with a 100 % survival rate of mice, low toxicity to normal cells and low residual rate. Such an infrared two‐photon activatable metal complex may contribute to a new generation of single‐molecule‐based integrated diagnosis and treatment platform to address drug resistance in clinical practice and phototherapy for large, deeply located solid tumors.
A single‐molecule‐based integrated diagnosis and treatment platform for infrared two‐photon excitable synergistic photodynamic, photothermal, and chemotherapy has been constructed. The most potent Ru7 enters cells via macropinocytosis and regulates DNA‐related chemotherapeutic mechanisms intranuclearly and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy and safety in vivo for melanoma and cisplatin‐resistant non‐small cell lung cancer. |
| doi_str_mv | 10.1002/anie.202402028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3046511383</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3046511383</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3038-58ab32075c895fa80bb0d8cdc440b65a78f5ba93a5088d9aefcf5d96baca6ad93</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhiMEoqVw5YgsceHQLE4cJ85xWbWwUguVWs7RxJk0rhw72Ina9MQj8Bp9rT4JTrcUiQuX8Xj8-TvMH0VvE7pKKE0_glG4Smma0VDEs2g_4WkSs6Jgz0OfMRYXgid70SvvrwIvBM1fRntM5DzPudiP7j6psVN26NDg_c9fx5ORo7IGtLrFhmxN68CF5uLahtezzo7WkHXtrRsWjJziCJpsbD9ovEFPwJNzZS714jq1GuWkkZxpGFvrek9CJeezQXep_KgkeRA2s4FeycPdbezQ9aAPCZiGbDrsHyYwzK-jFy1oj28ez4Po-_HRxeZLfPLt83azPoklo0zEXEDNUlpwKUregqB1TRshG5lltM45FKLlNZQMOBWiKQFb2fKmzGuQkENTsoPow847OPtjQj9WvfIStQaDdvIVo1nOk4QJFtD3_6BXdnJheQtVpIHkaRqo1Y6SznrvsK0Gp3pwc5XQagmxWkKsnkIMH949aqe6x-YJ_5NaAModcK00zv_RVeuv26O_8t_esbBG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3072304522</pqid></control><display><type>article</type><title>Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Li, Xue‐Lian ; Wang, Meng‐Fan ; Zeng, Li‐Zhen ; Li, Guo‐Kui ; Zhao, Run‐Yu ; Liu, Fu‐Dan ; Li, Yun ; Yan, Yu‐Fei ; Liu, Qishuai ; Li, Zhao ; Zhang, Hongbin ; Ren, Xiaoxia ; Gao, Feng</creator><creatorcontrib>Li, Xue‐Lian ; Wang, Meng‐Fan ; Zeng, Li‐Zhen ; Li, Guo‐Kui ; Zhao, Run‐Yu ; Liu, Fu‐Dan ; Li, Yun ; Yan, Yu‐Fei ; Liu, Qishuai ; Li, Zhao ; Zhang, Hongbin ; Ren, Xiaoxia ; Gao, Feng</creatorcontrib><description>A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two‐photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nuclei and mitochondria, and regulates DNA‐related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase and RNA polymerase inhibition and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy in vivo for malignant melanoma and cisplatin‐resistant non‐small cell lung cancer tumors, with a 100 % survival rate of mice, low toxicity to normal cells and low residual rate. Such an infrared two‐photon activatable metal complex may contribute to a new generation of single‐molecule‐based integrated diagnosis and treatment platform to address drug resistance in clinical practice and phototherapy for large, deeply located solid tumors.
A single‐molecule‐based integrated diagnosis and treatment platform for infrared two‐photon excitable synergistic photodynamic, photothermal, and chemotherapy has been constructed. The most potent Ru7 enters cells via macropinocytosis and regulates DNA‐related chemotherapeutic mechanisms intranuclearly and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy and safety in vivo for melanoma and cisplatin‐resistant non‐small cell lung cancer.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>ISSN: 1521-3773</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202402028</identifier><identifier>PMID: 38656658</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Absorption ; Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Aqueous solutions ; Biocompatibility ; Cell Line, Tumor ; Chemotherapy ; Cisplatin ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Coordination compounds ; Deoxyribonucleic acid ; DNA ; DNA topoisomerase ; DNA-directed RNA polymerase ; Drug resistance ; Drug Screening Assays, Antitumor ; Ferroptosis ; Humans ; I.R. radiation ; Infrared Rays ; Iridium - chemistry ; Irradiation ; Lung cancer ; Melanoma ; Metal complexes ; Mice ; Mitochondrial DNA ; Molecular Structure ; Photochemotherapy ; Photodynamic Therapy ; Photon absorption ; Photons ; Photosensitizing Agents - chemical synthesis ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Phototherapy ; Photothermal Therapy ; RNA polymerase ; Ruthenium - chemistry ; Ruthenium - pharmacology ; Singlet oxygen ; Small cell lung carcinoma ; Solid tumors ; Superoxide anions ; Survival ; Synergistic effect ; Thiophenes - chemistry ; Thiophenes - pharmacology ; Toxicity ; Tumor cells ; Tumors</subject><ispartof>Angewandte Chemie International Edition, 2024-07, Vol.63 (27), p.e202402028-n/a</ispartof><rights>2024 Wiley-VCH GmbH</rights><rights>2024 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3038-58ab32075c895fa80bb0d8cdc440b65a78f5ba93a5088d9aefcf5d96baca6ad93</citedby><cites>FETCH-LOGICAL-c3038-58ab32075c895fa80bb0d8cdc440b65a78f5ba93a5088d9aefcf5d96baca6ad93</cites><orcidid>0000-0001-7490-4887</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.202402028$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.202402028$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38656658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xue‐Lian</creatorcontrib><creatorcontrib>Wang, Meng‐Fan</creatorcontrib><creatorcontrib>Zeng, Li‐Zhen</creatorcontrib><creatorcontrib>Li, Guo‐Kui</creatorcontrib><creatorcontrib>Zhao, Run‐Yu</creatorcontrib><creatorcontrib>Liu, Fu‐Dan</creatorcontrib><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Yan, Yu‐Fei</creatorcontrib><creatorcontrib>Liu, Qishuai</creatorcontrib><creatorcontrib>Li, Zhao</creatorcontrib><creatorcontrib>Zhang, Hongbin</creatorcontrib><creatorcontrib>Ren, Xiaoxia</creatorcontrib><creatorcontrib>Gao, Feng</creatorcontrib><title>Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two‐photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nuclei and mitochondria, and regulates DNA‐related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase and RNA polymerase inhibition and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy in vivo for malignant melanoma and cisplatin‐resistant non‐small cell lung cancer tumors, with a 100 % survival rate of mice, low toxicity to normal cells and low residual rate. Such an infrared two‐photon activatable metal complex may contribute to a new generation of single‐molecule‐based integrated diagnosis and treatment platform to address drug resistance in clinical practice and phototherapy for large, deeply located solid tumors.
A single‐molecule‐based integrated diagnosis and treatment platform for infrared two‐photon excitable synergistic photodynamic, photothermal, and chemotherapy has been constructed. The most potent Ru7 enters cells via macropinocytosis and regulates DNA‐related chemotherapeutic mechanisms intranuclearly and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy and safety in vivo for melanoma and cisplatin‐resistant non‐small cell lung cancer.</description><subject>Absorption</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aqueous solutions</subject><subject>Biocompatibility</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Coordination compounds</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA topoisomerase</subject><subject>DNA-directed RNA polymerase</subject><subject>Drug resistance</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Ferroptosis</subject><subject>Humans</subject><subject>I.R. radiation</subject><subject>Infrared Rays</subject><subject>Iridium - chemistry</subject><subject>Irradiation</subject><subject>Lung cancer</subject><subject>Melanoma</subject><subject>Metal complexes</subject><subject>Mice</subject><subject>Mitochondrial DNA</subject><subject>Molecular Structure</subject><subject>Photochemotherapy</subject><subject>Photodynamic Therapy</subject><subject>Photon absorption</subject><subject>Photons</subject><subject>Photosensitizing Agents - chemical synthesis</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Phototherapy</subject><subject>Photothermal Therapy</subject><subject>RNA polymerase</subject><subject>Ruthenium - chemistry</subject><subject>Ruthenium - pharmacology</subject><subject>Singlet oxygen</subject><subject>Small cell lung carcinoma</subject><subject>Solid tumors</subject><subject>Superoxide anions</subject><subject>Survival</subject><subject>Synergistic effect</subject><subject>Thiophenes - chemistry</subject><subject>Thiophenes - pharmacology</subject><subject>Toxicity</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>1433-7851</issn><issn>1521-3773</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqVw5YgsceHQLE4cJ85xWbWwUguVWs7RxJk0rhw72Ina9MQj8Bp9rT4JTrcUiQuX8Xj8-TvMH0VvE7pKKE0_glG4Smma0VDEs2g_4WkSs6Jgz0OfMRYXgid70SvvrwIvBM1fRntM5DzPudiP7j6psVN26NDg_c9fx5ORo7IGtLrFhmxN68CF5uLahtezzo7WkHXtrRsWjJziCJpsbD9ovEFPwJNzZS714jq1GuWkkZxpGFvrek9CJeezQXep_KgkeRA2s4FeycPdbezQ9aAPCZiGbDrsHyYwzK-jFy1oj28ez4Po-_HRxeZLfPLt83azPoklo0zEXEDNUlpwKUregqB1TRshG5lltM45FKLlNZQMOBWiKQFb2fKmzGuQkENTsoPow847OPtjQj9WvfIStQaDdvIVo1nOk4QJFtD3_6BXdnJheQtVpIHkaRqo1Y6SznrvsK0Gp3pwc5XQagmxWkKsnkIMH949aqe6x-YJ_5NaAModcK00zv_RVeuv26O_8t_esbBG</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Li, Xue‐Lian</creator><creator>Wang, Meng‐Fan</creator><creator>Zeng, Li‐Zhen</creator><creator>Li, Guo‐Kui</creator><creator>Zhao, Run‐Yu</creator><creator>Liu, Fu‐Dan</creator><creator>Li, Yun</creator><creator>Yan, Yu‐Fei</creator><creator>Liu, Qishuai</creator><creator>Li, Zhao</creator><creator>Zhang, Hongbin</creator><creator>Ren, Xiaoxia</creator><creator>Gao, Feng</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7490-4887</orcidid></search><sort><creationdate>20240701</creationdate><title>Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy</title><author>Li, Xue‐Lian ; Wang, Meng‐Fan ; Zeng, Li‐Zhen ; Li, Guo‐Kui ; Zhao, Run‐Yu ; Liu, Fu‐Dan ; Li, Yun ; Yan, Yu‐Fei ; Liu, Qishuai ; Li, Zhao ; Zhang, Hongbin ; Ren, Xiaoxia ; Gao, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3038-58ab32075c895fa80bb0d8cdc440b65a78f5ba93a5088d9aefcf5d96baca6ad93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Aqueous solutions</topic><topic>Biocompatibility</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Coordination compounds</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA topoisomerase</topic><topic>DNA-directed RNA polymerase</topic><topic>Drug resistance</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Ferroptosis</topic><topic>Humans</topic><topic>I.R. radiation</topic><topic>Infrared Rays</topic><topic>Iridium - chemistry</topic><topic>Irradiation</topic><topic>Lung cancer</topic><topic>Melanoma</topic><topic>Metal complexes</topic><topic>Mice</topic><topic>Mitochondrial DNA</topic><topic>Molecular Structure</topic><topic>Photochemotherapy</topic><topic>Photodynamic Therapy</topic><topic>Photon absorption</topic><topic>Photons</topic><topic>Photosensitizing Agents - chemical synthesis</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Phototherapy</topic><topic>Photothermal Therapy</topic><topic>RNA polymerase</topic><topic>Ruthenium - chemistry</topic><topic>Ruthenium - pharmacology</topic><topic>Singlet oxygen</topic><topic>Small cell lung carcinoma</topic><topic>Solid tumors</topic><topic>Superoxide anions</topic><topic>Survival</topic><topic>Synergistic effect</topic><topic>Thiophenes - chemistry</topic><topic>Thiophenes - pharmacology</topic><topic>Toxicity</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xue‐Lian</creatorcontrib><creatorcontrib>Wang, Meng‐Fan</creatorcontrib><creatorcontrib>Zeng, Li‐Zhen</creatorcontrib><creatorcontrib>Li, Guo‐Kui</creatorcontrib><creatorcontrib>Zhao, Run‐Yu</creatorcontrib><creatorcontrib>Liu, Fu‐Dan</creatorcontrib><creatorcontrib>Li, Yun</creatorcontrib><creatorcontrib>Yan, Yu‐Fei</creatorcontrib><creatorcontrib>Liu, Qishuai</creatorcontrib><creatorcontrib>Li, Zhao</creatorcontrib><creatorcontrib>Zhang, Hongbin</creatorcontrib><creatorcontrib>Ren, Xiaoxia</creatorcontrib><creatorcontrib>Gao, Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xue‐Lian</au><au>Wang, Meng‐Fan</au><au>Zeng, Li‐Zhen</au><au>Li, Guo‐Kui</au><au>Zhao, Run‐Yu</au><au>Liu, Fu‐Dan</au><au>Li, Yun</au><au>Yan, Yu‐Fei</au><au>Liu, Qishuai</au><au>Li, Zhao</au><au>Zhang, Hongbin</au><au>Ren, Xiaoxia</au><au>Gao, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>63</volume><issue>27</issue><spage>e202402028</spage><epage>n/a</epage><pages>e202402028-n/a</pages><issn>1433-7851</issn><issn>1521-3773</issn><eissn>1521-3773</eissn><abstract>A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two‐photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nuclei and mitochondria, and regulates DNA‐related chemotherapeutic mechanisms intranuclearly including DNA topoisomerase and RNA polymerase inhibition and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy in vivo for malignant melanoma and cisplatin‐resistant non‐small cell lung cancer tumors, with a 100 % survival rate of mice, low toxicity to normal cells and low residual rate. Such an infrared two‐photon activatable metal complex may contribute to a new generation of single‐molecule‐based integrated diagnosis and treatment platform to address drug resistance in clinical practice and phototherapy for large, deeply located solid tumors.
A single‐molecule‐based integrated diagnosis and treatment platform for infrared two‐photon excitable synergistic photodynamic, photothermal, and chemotherapy has been constructed. The most potent Ru7 enters cells via macropinocytosis and regulates DNA‐related chemotherapeutic mechanisms intranuclearly and their synergistic effects with photoactivated apoptosis, ferroptosis and DNA cleavage. Ru7 exhibits high efficacy and safety in vivo for melanoma and cisplatin‐resistant non‐small cell lung cancer.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38656658</pmid><doi>10.1002/anie.202402028</doi><tpages>13</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0001-7490-4887</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2024-07, Vol.63 (27), p.e202402028-n/a |
| issn | 1433-7851 1521-3773 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3046511383 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absorption Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Aqueous solutions Biocompatibility Cell Line, Tumor Chemotherapy Cisplatin Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Coordination compounds Deoxyribonucleic acid DNA DNA topoisomerase DNA-directed RNA polymerase Drug resistance Drug Screening Assays, Antitumor Ferroptosis Humans I.R. radiation Infrared Rays Iridium - chemistry Irradiation Lung cancer Melanoma Metal complexes Mice Mitochondrial DNA Molecular Structure Photochemotherapy Photodynamic Therapy Photon absorption Photons Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Phototherapy Photothermal Therapy RNA polymerase Ruthenium - chemistry Ruthenium - pharmacology Singlet oxygen Small cell lung carcinoma Solid tumors Superoxide anions Survival Synergistic effect Thiophenes - chemistry Thiophenes - pharmacology Toxicity Tumor cells Tumors |
| title | Bithiophene‐Functionalized Infrared Two‐Photon Absorption Metal Complexes as Single‐Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T11%3A34%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bithiophene%E2%80%90Functionalized%20Infrared%20Two%E2%80%90Photon%20Absorption%20Metal%20Complexes%20as%20Single%E2%80%90Molecule%20Platforms%20for%20Synergistic%20Photodynamic,%20Photothermal,%20and%20Chemotherapy&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Li,%20Xue%E2%80%90Lian&rft.date=2024-07-01&rft.volume=63&rft.issue=27&rft.spage=e202402028&rft.epage=n/a&rft.pages=e202402028-n/a&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.202402028&rft_dat=%3Cproquest_cross%3E3046511383%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3072304522&rft_id=info:pmid/38656658&rfr_iscdi=true |