Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors

[Display omitted] •New 1,3,4-oxadiazole derivatives as potent mPGES-1 inhibitors are reported.•Compounds showed potent mPGES-1 inhibitory activity with IC50 of 5.6 – 82.3 nM.•TG554 selectively inhibits inflammatory PGE2 formation over all COX-derived prostanoids.•TG554 does not cause substrate shunt...

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Veröffentlicht in:	Bioorganic chemistry 2024-06, Vol.147, p.107383-107383, Article 107383
Hauptverfasser:	Gür Maz, Tuğçe, Dahlke, Philipp, Gizem Ergül, Azize, Olğaç, Abdurrahman, Jordan, Paul M., Çalışkan, Burcu, Werz, Oliver, Banoglu, Erden
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic acid Benzyloxyphenyl Cyclooxygenase Leukotrienes Lipidomics
Online-Zugang:	Volltext
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