Substance P in the medial amygdala regulates aggressive behaviors in male mice
Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykinin-expressing neurons in the medial amygdala (MeA neurons) are activated during aggressive b...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2024-10, Vol.49 (11), p.1689-1699 |
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| container_title | Neuropsychopharmacology (New York, N.Y.) |
| container_volume | 49 |
| creator | He, Zi-Xuan Yue, Mei-Hui Liu, Kai-Jie Wang, Yao Qiao, Jiu-Ye Lv, Xin-Yue Xi, Ke Zhang, Ya-Xin Fan, Jia-Ni Yu, Hua-Li He, Xiao-Xiao Zhu, Xiao-Juan |
| description | Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykinin-expressing neurons in the medial amygdala (MeA
neurons) are activated during aggressive behaviors in male mice. We identified MeA
neurons as a key mediator of aggression and found that MeA
→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) projections are critical to the regulation of aggression. Moreover, SP/neurokinin-1 receptor (NK-1R) signaling in the VMHvl modulates aggressive behaviors in male mice. SP/NK-1R signaling regulates aggression by influencing glutamate transmission in neurons in the VMHvl. In summary, these findings place SP as a key node in aggression circuits. |
| doi_str_mv | 10.1038/s41386-024-01863-w |
| format | Article |
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neurons) are activated during aggressive behaviors in male mice. We identified MeA
neurons as a key mediator of aggression and found that MeA
→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) projections are critical to the regulation of aggression. Moreover, SP/neurokinin-1 receptor (NK-1R) signaling in the VMHvl modulates aggressive behaviors in male mice. SP/NK-1R signaling regulates aggression by influencing glutamate transmission in neurons in the VMHvl. In summary, these findings place SP as a key node in aggression circuits.</description><identifier>ISSN: 0893-133X</identifier><identifier>ISSN: 1740-634X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-024-01863-w</identifier><identifier>PMID: 38649427</identifier><language>eng</language><publisher>England</publisher><subject>Aggression - physiology ; Animals ; Corticomedial Nuclear Complex - drug effects ; Corticomedial Nuclear Complex - metabolism ; Corticomedial Nuclear Complex - physiology ; Glutamic Acid - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways - physiology ; Neurons - metabolism ; Neurons - physiology ; Receptors, Neurokinin-1 - metabolism ; Substance P - metabolism ; Tachykinins - metabolism ; Ventromedial Hypothalamic Nucleus - drug effects ; Ventromedial Hypothalamic Nucleus - metabolism ; Ventromedial Hypothalamic Nucleus - physiology</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2024-10, Vol.49 (11), p.1689-1699</ispartof><rights>2024. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c254t-9382cb11c3db12b3f6bba1f4b65e5bba97b5643c3e87ef8a8819926d6735aab93</cites><orcidid>0000-0003-4819-1793 ; 0000-0003-3951-380X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38649427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Zi-Xuan</creatorcontrib><creatorcontrib>Yue, Mei-Hui</creatorcontrib><creatorcontrib>Liu, Kai-Jie</creatorcontrib><creatorcontrib>Wang, Yao</creatorcontrib><creatorcontrib>Qiao, Jiu-Ye</creatorcontrib><creatorcontrib>Lv, Xin-Yue</creatorcontrib><creatorcontrib>Xi, Ke</creatorcontrib><creatorcontrib>Zhang, Ya-Xin</creatorcontrib><creatorcontrib>Fan, Jia-Ni</creatorcontrib><creatorcontrib>Yu, Hua-Li</creatorcontrib><creatorcontrib>He, Xiao-Xiao</creatorcontrib><creatorcontrib>Zhu, Xiao-Juan</creatorcontrib><title>Substance P in the medial amygdala regulates aggressive behaviors in male mice</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykinin-expressing neurons in the medial amygdala (MeA
neurons) are activated during aggressive behaviors in male mice. We identified MeA
neurons as a key mediator of aggression and found that MeA
→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) projections are critical to the regulation of aggression. Moreover, SP/neurokinin-1 receptor (NK-1R) signaling in the VMHvl modulates aggressive behaviors in male mice. SP/NK-1R signaling regulates aggression by influencing glutamate transmission in neurons in the VMHvl. In summary, these findings place SP as a key node in aggression circuits.</description><subject>Aggression - physiology</subject><subject>Animals</subject><subject>Corticomedial Nuclear Complex - drug effects</subject><subject>Corticomedial Nuclear Complex - metabolism</subject><subject>Corticomedial Nuclear Complex - physiology</subject><subject>Glutamic Acid - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neural Pathways - physiology</subject><subject>Neurons - metabolism</subject><subject>Neurons - physiology</subject><subject>Receptors, Neurokinin-1 - metabolism</subject><subject>Substance P - metabolism</subject><subject>Tachykinins - metabolism</subject><subject>Ventromedial Hypothalamic Nucleus - drug effects</subject><subject>Ventromedial Hypothalamic Nucleus - metabolism</subject><subject>Ventromedial Hypothalamic Nucleus - physiology</subject><issn>0893-133X</issn><issn>1740-634X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1OwzAURi0EoqXwAgzII0vAznUcZ0QVf1IFSIDUzbKdmzQoaYqdtOrbk9LCdL_hnjMcQi45u-EM1G0QHJSMWCwixpWEaHNExjwVLJIg5sdkzFQGEQeYj8hZCF-M8SSV6pSMBkxkIk7H5OW9t6EzS4f0jVZL2i2QNphXpqam2Za5qQ31WPa16TBQU5YeQ6jWSC0uzLpqfdhRjakHrHJ4Tk4KUwe8ONwJ-Xy4_5g-RbPXx-fp3SxycSK6KAMVO8u5g9zy2EIhrTW8EFYmmAwzS20iBThAlWKhjFI8y2KZyxQSY2wGE3K99658-91j6HRTBYd1bZbY9kEDEwnnSgySCYn3r863IXgs9MpXjfFbzZneddT7jnroqH876s0AXR38vR1y_CN_4eAHuAdu4A</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>He, Zi-Xuan</creator><creator>Yue, Mei-Hui</creator><creator>Liu, Kai-Jie</creator><creator>Wang, Yao</creator><creator>Qiao, Jiu-Ye</creator><creator>Lv, Xin-Yue</creator><creator>Xi, Ke</creator><creator>Zhang, Ya-Xin</creator><creator>Fan, Jia-Ni</creator><creator>Yu, Hua-Li</creator><creator>He, Xiao-Xiao</creator><creator>Zhu, Xiao-Juan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4819-1793</orcidid><orcidid>https://orcid.org/0000-0003-3951-380X</orcidid></search><sort><creationdate>20241001</creationdate><title>Substance P in the medial amygdala regulates aggressive behaviors in male mice</title><author>He, Zi-Xuan ; Yue, Mei-Hui ; Liu, Kai-Jie ; Wang, Yao ; Qiao, Jiu-Ye ; Lv, Xin-Yue ; Xi, Ke ; Zhang, Ya-Xin ; Fan, Jia-Ni ; Yu, Hua-Li ; He, Xiao-Xiao ; Zhu, Xiao-Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-9382cb11c3db12b3f6bba1f4b65e5bba97b5643c3e87ef8a8819926d6735aab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aggression - physiology</topic><topic>Animals</topic><topic>Corticomedial Nuclear Complex - drug effects</topic><topic>Corticomedial Nuclear Complex - metabolism</topic><topic>Corticomedial Nuclear Complex - physiology</topic><topic>Glutamic Acid - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neural Pathways - physiology</topic><topic>Neurons - metabolism</topic><topic>Neurons - physiology</topic><topic>Receptors, Neurokinin-1 - metabolism</topic><topic>Substance P - metabolism</topic><topic>Tachykinins - metabolism</topic><topic>Ventromedial Hypothalamic Nucleus - drug effects</topic><topic>Ventromedial Hypothalamic Nucleus - metabolism</topic><topic>Ventromedial Hypothalamic Nucleus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Zi-Xuan</creatorcontrib><creatorcontrib>Yue, Mei-Hui</creatorcontrib><creatorcontrib>Liu, Kai-Jie</creatorcontrib><creatorcontrib>Wang, Yao</creatorcontrib><creatorcontrib>Qiao, Jiu-Ye</creatorcontrib><creatorcontrib>Lv, Xin-Yue</creatorcontrib><creatorcontrib>Xi, Ke</creatorcontrib><creatorcontrib>Zhang, Ya-Xin</creatorcontrib><creatorcontrib>Fan, Jia-Ni</creatorcontrib><creatorcontrib>Yu, Hua-Li</creatorcontrib><creatorcontrib>He, Xiao-Xiao</creatorcontrib><creatorcontrib>Zhu, Xiao-Juan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Zi-Xuan</au><au>Yue, Mei-Hui</au><au>Liu, Kai-Jie</au><au>Wang, Yao</au><au>Qiao, Jiu-Ye</au><au>Lv, Xin-Yue</au><au>Xi, Ke</au><au>Zhang, Ya-Xin</au><au>Fan, Jia-Ni</au><au>Yu, Hua-Li</au><au>He, Xiao-Xiao</au><au>Zhu, Xiao-Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substance P in the medial amygdala regulates aggressive behaviors in male mice</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>49</volume><issue>11</issue><spage>1689</spage><epage>1699</epage><pages>1689-1699</pages><issn>0893-133X</issn><issn>1740-634X</issn><eissn>1740-634X</eissn><abstract>Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykinin-expressing neurons in the medial amygdala (MeA
neurons) are activated during aggressive behaviors in male mice. We identified MeA
neurons as a key mediator of aggression and found that MeA
→ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) projections are critical to the regulation of aggression. Moreover, SP/neurokinin-1 receptor (NK-1R) signaling in the VMHvl modulates aggressive behaviors in male mice. SP/NK-1R signaling regulates aggression by influencing glutamate transmission in neurons in the VMHvl. In summary, these findings place SP as a key node in aggression circuits.</abstract><cop>England</cop><pmid>38649427</pmid><doi>10.1038/s41386-024-01863-w</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4819-1793</orcidid><orcidid>https://orcid.org/0000-0003-3951-380X</orcidid></addata></record> |
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| ispartof | Neuropsychopharmacology (New York, N.Y.), 2024-10, Vol.49 (11), p.1689-1699 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aggression - physiology Animals Corticomedial Nuclear Complex - drug effects Corticomedial Nuclear Complex - metabolism Corticomedial Nuclear Complex - physiology Glutamic Acid - metabolism Male Mice Mice, Inbred C57BL Neural Pathways - physiology Neurons - metabolism Neurons - physiology Receptors, Neurokinin-1 - metabolism Substance P - metabolism Tachykinins - metabolism Ventromedial Hypothalamic Nucleus - drug effects Ventromedial Hypothalamic Nucleus - metabolism Ventromedial Hypothalamic Nucleus - physiology |
| title | Substance P in the medial amygdala regulates aggressive behaviors in male mice |
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