Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan
Purpose This study investigated the prognostic value of the geriatric nutritional risk index (GNRI) in patients undergoing curative gastrectomy for remnant gastric cancer (RGC). Methods This multicenter retrospective study included 105 patients with RGC of ≥ 65 years of age who underwent curative ga...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2024-11, Vol.54 (11), p.1360-1368 |
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| creator | Matsunaga, Tomoyuki Saito, Hiroaki Osaki, Tomohiro Fukuda, Kenji Fukumoto, Yoji Takahashi, Sadamu Taniguchi, Kenjiro Iwamoto, Akemi Kuroda, Hirohiko Katano, Kuniyuki Shimizu, Shota Shishido, Yuji Miyatani, Kozo Sakamoto, Teruhisa Fujiwara, Yoshiyuki |
| description | Purpose
This study investigated the prognostic value of the geriatric nutritional risk index (GNRI) in patients undergoing curative gastrectomy for remnant gastric cancer (RGC).
Methods
This multicenter retrospective study included 105 patients with RGC of ≥ 65 years of age who underwent curative gastrectomy at 10 institutions in Japan between January 2000 and December 2016. Postoperative complications, overall survival (OS), and disease-specific survival (DSS) were analyzed.
Results
Receiver operating curve analyses indicated that the optimal cutoff value of the GNRI for OS was 95.4. Patients were categorized into high and low GNRI groups based on the optimal GNRI cutoff value. The GNRI was significantly correlated with body mass index (
p
|
| doi_str_mv | 10.1007/s00595-024-02850-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3045118205</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3045118205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-2cbd0e00df2fbd49f7ec7aeba980461dc56dfce1b91c709cd7194a1dc36d75c13</originalsourceid><addsrcrecordid>eNp9kU1uFDEQhS0EIkPCBVggL9l0KLv_2aEICCgSm2Rtue3qiUO33djuDHMlTpnKTGCZhV3Sq69eyX6MvRNwLgDajwmg7usCZEWnq6HYvWAbUZVNITtRvmQb6CtRCNmLE_YmpTsgsgN4zU7KrqllCbBhf2-S81ueb5FvMTqdozPcr1SyC15PPLr0iztv8Q_PgS8RrTOZhzWbMGOiDg-TxcgXnR36nPjO5VsecfbaZ77V6eBotDcE6THTfRDR5DDvP3FNbI4hLSS4e-TzOmVnyInAlFe7f1zxQy_an7FXo54Svn2qp-zm65fri8vi6ue37xefrwoj-y4X0gwWEMCOchxs1Y8tmlbjoPsOqkZYUzd2NCiGXpgWemNb0Vea9LKxbW1Eeco-HH2XGH6vmLKaXTI4TdpjWJMqoaqF6CTUhMojaugFKeKoluhmHfdKgHrMSB0zUvTz6pCR2tHQ-yf_dZjR_h_5FwoB5RFI1PIUi7oLa6Qw0nO2D9BGo18</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3045118205</pqid></control><display><type>article</type><title>Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Matsunaga, Tomoyuki ; Saito, Hiroaki ; Osaki, Tomohiro ; Fukuda, Kenji ; Fukumoto, Yoji ; Takahashi, Sadamu ; Taniguchi, Kenjiro ; Iwamoto, Akemi ; Kuroda, Hirohiko ; Katano, Kuniyuki ; Shimizu, Shota ; Shishido, Yuji ; Miyatani, Kozo ; Sakamoto, Teruhisa ; Fujiwara, Yoshiyuki</creator><creatorcontrib>Matsunaga, Tomoyuki ; Saito, Hiroaki ; Osaki, Tomohiro ; Fukuda, Kenji ; Fukumoto, Yoji ; Takahashi, Sadamu ; Taniguchi, Kenjiro ; Iwamoto, Akemi ; Kuroda, Hirohiko ; Katano, Kuniyuki ; Shimizu, Shota ; Shishido, Yuji ; Miyatani, Kozo ; Sakamoto, Teruhisa ; Fujiwara, Yoshiyuki</creatorcontrib><description>Purpose
This study investigated the prognostic value of the geriatric nutritional risk index (GNRI) in patients undergoing curative gastrectomy for remnant gastric cancer (RGC).
Methods
This multicenter retrospective study included 105 patients with RGC of ≥ 65 years of age who underwent curative gastrectomy at 10 institutions in Japan between January 2000 and December 2016. Postoperative complications, overall survival (OS), and disease-specific survival (DSS) were analyzed.
Results
Receiver operating curve analyses indicated that the optimal cutoff value of the GNRI for OS was 95.4. Patients were categorized into high and low GNRI groups based on the optimal GNRI cutoff value. The GNRI was significantly correlated with body mass index (
p
< 0.001), amount of bleeding (
p
= 0.021), Clavien–Dindo grade 5 postoperative complications (
p
= 0.040), death caused by primary disease (
p
= 0.010), and death caused by other diseases (
p
= 0.002). The OS and DSS were significantly worse in the low GNRI group. A low GNRI and T3 or deeper tumor invasion were independent prognostic factors for OS and DSS.
Conclusions
The GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC.</description><identifier>ISSN: 0941-1291</identifier><identifier>ISSN: 1436-2813</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-024-02850-w</identifier><identifier>PMID: 38652300</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Aged ; Aged, 80 and over ; Female ; Gastrectomy ; Gastric Stump - pathology ; Geriatric Assessment - methods ; Humans ; Japan - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Nutrition Assessment ; Original Article ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk ; Risk Assessment - methods ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgery ; Surgical Oncology ; Survival Rate ; Treatment Outcome</subject><ispartof>Surgery today (Tokyo, Japan), 2024-11, Vol.54 (11), p.1360-1368</ispartof><rights>The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-2cbd0e00df2fbd49f7ec7aeba980461dc56dfce1b91c709cd7194a1dc36d75c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-024-02850-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-024-02850-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38652300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsunaga, Tomoyuki</creatorcontrib><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Osaki, Tomohiro</creatorcontrib><creatorcontrib>Fukuda, Kenji</creatorcontrib><creatorcontrib>Fukumoto, Yoji</creatorcontrib><creatorcontrib>Takahashi, Sadamu</creatorcontrib><creatorcontrib>Taniguchi, Kenjiro</creatorcontrib><creatorcontrib>Iwamoto, Akemi</creatorcontrib><creatorcontrib>Kuroda, Hirohiko</creatorcontrib><creatorcontrib>Katano, Kuniyuki</creatorcontrib><creatorcontrib>Shimizu, Shota</creatorcontrib><creatorcontrib>Shishido, Yuji</creatorcontrib><creatorcontrib>Miyatani, Kozo</creatorcontrib><creatorcontrib>Sakamoto, Teruhisa</creatorcontrib><creatorcontrib>Fujiwara, Yoshiyuki</creatorcontrib><title>Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
This study investigated the prognostic value of the geriatric nutritional risk index (GNRI) in patients undergoing curative gastrectomy for remnant gastric cancer (RGC).
Methods
This multicenter retrospective study included 105 patients with RGC of ≥ 65 years of age who underwent curative gastrectomy at 10 institutions in Japan between January 2000 and December 2016. Postoperative complications, overall survival (OS), and disease-specific survival (DSS) were analyzed.
Results
Receiver operating curve analyses indicated that the optimal cutoff value of the GNRI for OS was 95.4. Patients were categorized into high and low GNRI groups based on the optimal GNRI cutoff value. The GNRI was significantly correlated with body mass index (
p
< 0.001), amount of bleeding (
p
= 0.021), Clavien–Dindo grade 5 postoperative complications (
p
= 0.040), death caused by primary disease (
p
= 0.010), and death caused by other diseases (
p
= 0.002). The OS and DSS were significantly worse in the low GNRI group. A low GNRI and T3 or deeper tumor invasion were independent prognostic factors for OS and DSS.
Conclusions
The GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Gastric Stump - pathology</subject><subject>Geriatric Assessment - methods</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nutrition Assessment</subject><subject>Original Article</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk Assessment - methods</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0941-1291</issn><issn>1436-2813</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1uFDEQhS0EIkPCBVggL9l0KLv_2aEICCgSm2Rtue3qiUO33djuDHMlTpnKTGCZhV3Sq69eyX6MvRNwLgDajwmg7usCZEWnq6HYvWAbUZVNITtRvmQb6CtRCNmLE_YmpTsgsgN4zU7KrqllCbBhf2-S81ueb5FvMTqdozPcr1SyC15PPLr0iztv8Q_PgS8RrTOZhzWbMGOiDg-TxcgXnR36nPjO5VsecfbaZ77V6eBotDcE6THTfRDR5DDvP3FNbI4hLSS4e-TzOmVnyInAlFe7f1zxQy_an7FXo54Svn2qp-zm65fri8vi6ue37xefrwoj-y4X0gwWEMCOchxs1Y8tmlbjoPsOqkZYUzd2NCiGXpgWemNb0Vea9LKxbW1Eeco-HH2XGH6vmLKaXTI4TdpjWJMqoaqF6CTUhMojaugFKeKoluhmHfdKgHrMSB0zUvTz6pCR2tHQ-yf_dZjR_h_5FwoB5RFI1PIUi7oLa6Qw0nO2D9BGo18</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Matsunaga, Tomoyuki</creator><creator>Saito, Hiroaki</creator><creator>Osaki, Tomohiro</creator><creator>Fukuda, Kenji</creator><creator>Fukumoto, Yoji</creator><creator>Takahashi, Sadamu</creator><creator>Taniguchi, Kenjiro</creator><creator>Iwamoto, Akemi</creator><creator>Kuroda, Hirohiko</creator><creator>Katano, Kuniyuki</creator><creator>Shimizu, Shota</creator><creator>Shishido, Yuji</creator><creator>Miyatani, Kozo</creator><creator>Sakamoto, Teruhisa</creator><creator>Fujiwara, Yoshiyuki</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan</title><author>Matsunaga, Tomoyuki ; Saito, Hiroaki ; Osaki, Tomohiro ; Fukuda, Kenji ; Fukumoto, Yoji ; Takahashi, Sadamu ; Taniguchi, Kenjiro ; Iwamoto, Akemi ; Kuroda, Hirohiko ; Katano, Kuniyuki ; Shimizu, Shota ; Shishido, Yuji ; Miyatani, Kozo ; Sakamoto, Teruhisa ; Fujiwara, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-2cbd0e00df2fbd49f7ec7aeba980461dc56dfce1b91c709cd7194a1dc36d75c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Gastric Stump - pathology</topic><topic>Geriatric Assessment - methods</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nutrition Assessment</topic><topic>Original Article</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk Assessment - methods</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsunaga, Tomoyuki</creatorcontrib><creatorcontrib>Saito, Hiroaki</creatorcontrib><creatorcontrib>Osaki, Tomohiro</creatorcontrib><creatorcontrib>Fukuda, Kenji</creatorcontrib><creatorcontrib>Fukumoto, Yoji</creatorcontrib><creatorcontrib>Takahashi, Sadamu</creatorcontrib><creatorcontrib>Taniguchi, Kenjiro</creatorcontrib><creatorcontrib>Iwamoto, Akemi</creatorcontrib><creatorcontrib>Kuroda, Hirohiko</creatorcontrib><creatorcontrib>Katano, Kuniyuki</creatorcontrib><creatorcontrib>Shimizu, Shota</creatorcontrib><creatorcontrib>Shishido, Yuji</creatorcontrib><creatorcontrib>Miyatani, Kozo</creatorcontrib><creatorcontrib>Sakamoto, Teruhisa</creatorcontrib><creatorcontrib>Fujiwara, Yoshiyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsunaga, Tomoyuki</au><au>Saito, Hiroaki</au><au>Osaki, Tomohiro</au><au>Fukuda, Kenji</au><au>Fukumoto, Yoji</au><au>Takahashi, Sadamu</au><au>Taniguchi, Kenjiro</au><au>Iwamoto, Akemi</au><au>Kuroda, Hirohiko</au><au>Katano, Kuniyuki</au><au>Shimizu, Shota</au><au>Shishido, Yuji</au><au>Miyatani, Kozo</au><au>Sakamoto, Teruhisa</au><au>Fujiwara, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>54</volume><issue>11</issue><spage>1360</spage><epage>1368</epage><pages>1360-1368</pages><issn>0941-1291</issn><issn>1436-2813</issn><eissn>1436-2813</eissn><abstract>Purpose
This study investigated the prognostic value of the geriatric nutritional risk index (GNRI) in patients undergoing curative gastrectomy for remnant gastric cancer (RGC).
Methods
This multicenter retrospective study included 105 patients with RGC of ≥ 65 years of age who underwent curative gastrectomy at 10 institutions in Japan between January 2000 and December 2016. Postoperative complications, overall survival (OS), and disease-specific survival (DSS) were analyzed.
Results
Receiver operating curve analyses indicated that the optimal cutoff value of the GNRI for OS was 95.4. Patients were categorized into high and low GNRI groups based on the optimal GNRI cutoff value. The GNRI was significantly correlated with body mass index (
p
< 0.001), amount of bleeding (
p
= 0.021), Clavien–Dindo grade 5 postoperative complications (
p
= 0.040), death caused by primary disease (
p
= 0.010), and death caused by other diseases (
p
= 0.002). The OS and DSS were significantly worse in the low GNRI group. A low GNRI and T3 or deeper tumor invasion were independent prognostic factors for OS and DSS.
Conclusions
The GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38652300</pmid><doi>10.1007/s00595-024-02850-w</doi><tpages>9</tpages></addata></record> |
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| ispartof | Surgery today (Tokyo, Japan), 2024-11, Vol.54 (11), p.1360-1368 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Aged, 80 and over Female Gastrectomy Gastric Stump - pathology Geriatric Assessment - methods Humans Japan - epidemiology Male Medicine Medicine & Public Health Nutrition Assessment Original Article Postoperative Complications - epidemiology Postoperative Complications - etiology Predictive Value of Tests Prognosis Retrospective Studies Risk Risk Assessment - methods Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Surgical Oncology Survival Rate Treatment Outcome |
| title | Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan |
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