Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies
The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101 (30%). It was mostly bilateral (93%), not associ...
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| Veröffentlicht in: | Journal of Neuroimmunology 2024-05, Vol.390, p.578346, Article 578346 |
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| creator | Campetella, Lucia Villagrán-García, Macarena Farina, Antonio Benaiteau, Marie Iorio, Raffaele Calabresi, Paolo Vogrig, Alberto Versace, Salvatore Ciano-Petersen, Nicolás Lundahl Bicilli Brotelle, Elodie Branger, Pierre Verlut, Clotilde Langner-Lemercier, Sophie Leclancher, Alexandre Duwicquet, Coline Charif, Mahmoud Kerschen, Philippe Capet, Nicolas Renard, Dimitri Chanson, Eve Rafiq, Marie Tyvaert, Louise Joubert, Bastien Cotton, François Honnorat, Jérôme Muñiz-Castrillo, Sergio |
| description | The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101 (30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%). In a systematic review including patients with other neuroglial antibodies, CST hyperintensity was reported in 110 with neuromyelitis optica (94%), myelin oligodendrocyte glycoprotein-associated disease (2%), Ma2-antibody (3%) and GAD65-antibody paraneoplastic neurological syndrome (1%). CST hyperintensity is not an infrequent finding in LGI1-Ab encephalitis and other disorders with neuroglial antibodies.
[Display omitted]
•Brain MRI corticospinal tract hyperintensity elicits a broad differential diagnosis.•Its overall frequency in brain disorders with neuroglial antibodies is unclear.•It is present in 30% among 101 patients with LGI1-antibody encephalitis.•In the literature it is reported in 110 patients with diverse neuroglial antibodies.•Corticospinal tract hyperintensity is not rare in autoimmune brain disorders. |
| doi_str_mv | 10.1016/j.jneuroim.2024.578346 |
| format | Article |
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[Display omitted]
•Brain MRI corticospinal tract hyperintensity elicits a broad differential diagnosis.•Its overall frequency in brain disorders with neuroglial antibodies is unclear.•It is present in 30% among 101 patients with LGI1-antibody encephalitis.•In the literature it is reported in 110 patients with diverse neuroglial antibodies.•Corticospinal tract hyperintensity is not rare in autoimmune brain disorders.</description><identifier>ISSN: 0165-5728</identifier><identifier>ISSN: 1872-8421</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2024.578346</identifier><identifier>PMID: 38648696</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Autoimmune encephalitis ; Corticospinal tracts ; Inflammatory diseases ; LGI1 ; Life Sciences</subject><ispartof>Journal of Neuroimmunology, 2024-05, Vol.390, p.578346, Article 578346</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c349t-3ef209bd9598624a42da624c9f9b3a619f2ab20306424ecd7094c1081d6828893</cites><orcidid>0000-0003-0046-2478</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2024.578346$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,883,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38648696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04648638$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Campetella, Lucia</creatorcontrib><creatorcontrib>Villagrán-García, Macarena</creatorcontrib><creatorcontrib>Farina, Antonio</creatorcontrib><creatorcontrib>Benaiteau, Marie</creatorcontrib><creatorcontrib>Iorio, Raffaele</creatorcontrib><creatorcontrib>Calabresi, Paolo</creatorcontrib><creatorcontrib>Vogrig, Alberto</creatorcontrib><creatorcontrib>Versace, Salvatore</creatorcontrib><creatorcontrib>Ciano-Petersen, Nicolás Lundahl</creatorcontrib><creatorcontrib>Bicilli Brotelle, Elodie</creatorcontrib><creatorcontrib>Branger, Pierre</creatorcontrib><creatorcontrib>Verlut, Clotilde</creatorcontrib><creatorcontrib>Langner-Lemercier, Sophie</creatorcontrib><creatorcontrib>Leclancher, Alexandre</creatorcontrib><creatorcontrib>Duwicquet, Coline</creatorcontrib><creatorcontrib>Charif, Mahmoud</creatorcontrib><creatorcontrib>Kerschen, Philippe</creatorcontrib><creatorcontrib>Capet, Nicolas</creatorcontrib><creatorcontrib>Renard, Dimitri</creatorcontrib><creatorcontrib>Chanson, Eve</creatorcontrib><creatorcontrib>Rafiq, Marie</creatorcontrib><creatorcontrib>Tyvaert, Louise</creatorcontrib><creatorcontrib>Joubert, Bastien</creatorcontrib><creatorcontrib>Cotton, François</creatorcontrib><creatorcontrib>Honnorat, Jérôme</creatorcontrib><creatorcontrib>Muñiz-Castrillo, Sergio</creatorcontrib><title>Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies</title><title>Journal of Neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101 (30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%). In a systematic review including patients with other neuroglial antibodies, CST hyperintensity was reported in 110 with neuromyelitis optica (94%), myelin oligodendrocyte glycoprotein-associated disease (2%), Ma2-antibody (3%) and GAD65-antibody paraneoplastic neurological syndrome (1%). CST hyperintensity is not an infrequent finding in LGI1-Ab encephalitis and other disorders with neuroglial antibodies.
[Display omitted]
•Brain MRI corticospinal tract hyperintensity elicits a broad differential diagnosis.•Its overall frequency in brain disorders with neuroglial antibodies is unclear.•It is present in 30% among 101 patients with LGI1-antibody encephalitis.•In the literature it is reported in 110 patients with diverse neuroglial antibodies.•Corticospinal tract hyperintensity is not rare in autoimmune brain disorders.</description><subject>Autoimmune encephalitis</subject><subject>Corticospinal tracts</subject><subject>Inflammatory diseases</subject><subject>LGI1</subject><subject>Life Sciences</subject><issn>0165-5728</issn><issn>1872-8421</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkUFvEzEQhVcIRNPCX6h8hMMG2-t1vDeqCNpKkbjA2fLas2Sijb3YTlD-R38wXpL22tNI1jdv_N6rqltGl4wy-WW33Hk4xID7JadcLNuVaoR8Uy2YWvFaCc7eVosCtnW74uqquk5pRylrG9G9r64aJYWSnVxUT-sQM9qQJvRmJDkam8n2NEFEn8EnzCeCnkwmI_icyF_MW7K5f2S18Rn74E4EvIVpa0bMmIjxjoS8hUhs4WOR9BCP4ZBIOqUMe-IwheggXqT-m_g9YgEvggjpQ_VuMGOCj5d5U_36_u3n-qHe_Lh_XN9talts5LqBgdOud13bKcmFEdyZMm03dH1jJOsGbnpOGyoFF2DdinbCMqqYk4or1TU31eezbvm9niLuTTzpYFA_3G30_EbFnFOjjqywn87sFMOfA6Ss95gsjKPxUOzphoqWMcnaWVaeURtDShGGF21G9dye3unn9vTcnj63VxZvLzcO_R7cy9pzXQX4egagpHJEiDpZnPN3GMFm7QK-duMfcq-x5w</recordid><startdate>20240515</startdate><enddate>20240515</enddate><creator>Campetella, Lucia</creator><creator>Villagrán-García, Macarena</creator><creator>Farina, Antonio</creator><creator>Benaiteau, Marie</creator><creator>Iorio, Raffaele</creator><creator>Calabresi, Paolo</creator><creator>Vogrig, Alberto</creator><creator>Versace, Salvatore</creator><creator>Ciano-Petersen, Nicolás Lundahl</creator><creator>Bicilli Brotelle, Elodie</creator><creator>Branger, Pierre</creator><creator>Verlut, Clotilde</creator><creator>Langner-Lemercier, Sophie</creator><creator>Leclancher, Alexandre</creator><creator>Duwicquet, Coline</creator><creator>Charif, Mahmoud</creator><creator>Kerschen, Philippe</creator><creator>Capet, Nicolas</creator><creator>Renard, Dimitri</creator><creator>Chanson, Eve</creator><creator>Rafiq, Marie</creator><creator>Tyvaert, Louise</creator><creator>Joubert, Bastien</creator><creator>Cotton, François</creator><creator>Honnorat, Jérôme</creator><creator>Muñiz-Castrillo, Sergio</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0046-2478</orcidid></search><sort><creationdate>20240515</creationdate><title>Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies</title><author>Campetella, Lucia ; 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Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101 (30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%). In a systematic review including patients with other neuroglial antibodies, CST hyperintensity was reported in 110 with neuromyelitis optica (94%), myelin oligodendrocyte glycoprotein-associated disease (2%), Ma2-antibody (3%) and GAD65-antibody paraneoplastic neurological syndrome (1%). CST hyperintensity is not an infrequent finding in LGI1-Ab encephalitis and other disorders with neuroglial antibodies.
[Display omitted]
•Brain MRI corticospinal tract hyperintensity elicits a broad differential diagnosis.•Its overall frequency in brain disorders with neuroglial antibodies is unclear.•It is present in 30% among 101 patients with LGI1-antibody encephalitis.•In the literature it is reported in 110 patients with diverse neuroglial antibodies.•Corticospinal tract hyperintensity is not rare in autoimmune brain disorders.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38648696</pmid><doi>10.1016/j.jneuroim.2024.578346</doi><orcidid>https://orcid.org/0000-0003-0046-2478</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Autoimmune encephalitis Corticospinal tracts Inflammatory diseases LGI1 Life Sciences |
| title | Corticospinal tract hyperintensity in patients with LGI1-antibody encephalitis and other central nervous system disorders with neuroglial antibodies |
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