Calcineurin-NFAT signaling controls neutrophils' ability of chemoattraction upon fungal infection

Calcineurin-nuclear factor of activated T cells (CN-NFAT) inhibitors are widely clinically used drugs for immunosuppression, but besides their required T cell response inhibition, they also undesirably affect innate immune cells. Disruption of innate immune cell function can explain the observed sus...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of leukocyte biology 2024-10, Vol.116 (4), p.816-829
Hauptverfasser:	Vymazal, Ondrej, Papatheodorou, Ioanna, Andrejčinová, Ivana, Bosáková, Veronika, Vascelli, Gianluca, Bendíčková, Kamila, Zelante, Teresa, Hortová-Kohoutková, Marcela, Frič, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus fumigatus - immunology Calcineurin - metabolism Candida albicans - immunology Chemotaxis Humans Mycoses - immunology Neutrophils - immunology Neutrophils - metabolism NFATC Transcription Factors - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!