Local Alpha1‐Antitrypsin Accelerates the Healing of Tympanic Membrane Perforation in Mice

Background Most tympanic membrane (TM) perforations heal spontaneously, but 10%–20% remain chronic and might lead to impaired hearing and recurrent middle ear infections. Alpha1‐antitrypsin (AAT) is a circulating tissue‐protective protein that is elevated under inflammatory conditions and is current...

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Veröffentlicht in:	The Laryngoscope 2024-08, Vol.134 (8), p.3802-3806
Hauptverfasser:	El‐Saied, Sabri, Amar, Amit, Kaplan, Daniel M., Shitrit, Rivka, Kaminer, Benyamin M., Keshet, Aharon, Lewis, Eli C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - pharmacology Animals Disease Models, Animal Eardrum Ears & hearing growth factor inflammation Mice Mice, Inbred C57BL tissue repair tympanic membrane perforation Tympanic Membrane Perforation - drug therapy wound healing Wound Healing - drug effects
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