Mesenchymal stem cells as therapeutic vehicles for glioma
Glioma is a disease with a poor prognosis despite the availability of multimodality treatments, and the development of novel therapies is urgently needed. Challenges in glioma treatment include the difficulty for drugs to cross the blood–brain barrier when administered systemically and poor drug dif...
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| Veröffentlicht in: | Cancer gene therapy 2024-09, Vol.31 (9), p.1306-1314 |
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| creator | Oishi, Tomoya Koizumi, Shinichiro Kurozumi, Kazuhiko |
| description | Glioma is a disease with a poor prognosis despite the availability of multimodality treatments, and the development of novel therapies is urgently needed. Challenges in glioma treatment include the difficulty for drugs to cross the blood–brain barrier when administered systemically and poor drug diffusion when administered locally. Mesenchymal stem cells exhibit advantages for glioma therapy because of their ability to pass through the blood–brain barrier and migrate to tumor cells and their tolerance to the immune system. Therefore, mesenchymal stem cells have been explored as vehicles for various therapeutic agents for glioma treatment. Mesenchymal stem cells loaded with chemotherapeutic drugs show improved penetration and tumor accumulation. For gene therapy, mesenchymal stem cells can be used as vehicles for suicide genes, the so-called gene-directed enzyme prodrug therapy. Mesenchymal stem cell-based oncolytic viral therapies have been attempted in recent years to enhance the efficacy of infection against the tumor, viral replication, and distribution of viral particles. Many uncertainties remain regarding the function and behavior of mesenchymal stem cells in gliomas. However, strategies to increase mesenchymal stem cell migration to gliomas may improve the delivery of therapeutic agents and enhance their anti-tumor effects, representing promising potential for patient treatment. |
| doi_str_mv | 10.1038/s41417-024-00775-7 |
| format | Article |
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| subjects | 13/100 42/44 631/67/1059/153 692/699/67/1922 Animals Antineoplastic drugs Biomedical and Life Sciences Biomedicine Blood-brain barrier Brain Neoplasms - pathology Brain Neoplasms - therapy Brain tumors Cell migration Chemotherapy Drug delivery systems Drug development Drug tolerance Gene Expression Gene Therapy Genetic Therapy - methods Glioma Glioma - therapy Glioma cells Humans Immune system Immunological tolerance Immunosuppressive agents Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Oncolysis Oncolytic Virotherapy - methods Review Article Stem cells Suicide genes Tumor cells |
| title | Mesenchymal stem cells as therapeutic vehicles for glioma |
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