Beyond antiviral: role of IFN-I in brain development
Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, Escoubas, Dorman, et al. recently identified a role for m...
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| Veröffentlicht in: | Trends in immunology 2024-05, Vol.45 (5), p.322-324 |
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| container_title | Trends in immunology |
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| creator | Baker, Christopher A. Iwasaki, Akiko |
| description | Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, Escoubas, Dorman, et al. recently identified a role for microglial type I interferon signaling in the clearance of unwanted neurons during mouse brain development.
Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, Escoubas, Dorman, et al. recently identified a role for microglial type I interferon signaling in the clearance of unwanted neurons during mouse brain development. |
| doi_str_mv | 10.1016/j.it.2024.04.004 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain - growth & development Brain - immunology Humans Interferon Type I - immunology Interferon Type I - metabolism Mice Microglia - immunology Microglia - metabolism Neuronal Plasticity - immunology Neurons - immunology Neurons - metabolism Phagocytosis - immunology Signal Transduction - immunology |
| title | Beyond antiviral: role of IFN-I in brain development |
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