Fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: A systematic review and meta-analysis
This study will explore the effectiveness of fish skin grafts (FSG) in ulcer healing in diabetic foot disease compared to standard of care (SOC). The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard....
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| Veröffentlicht in: | Primary care diabetes 2024-06, Vol.18 (3), p.291-298 |
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| creator | Ruiz-Muñoz, Maria Martinez-Barrios, Francisco-Javier Cervera-Garvi, Pablo Lopezosa-Reca, Eva Marchena-Rodriguez, Ana J. |
| description | This study will explore the effectiveness of fish skin grafts (FSG) in ulcer healing in diabetic foot disease compared to standard of care (SOC).
The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing. The risk of bias assessment was conducted using the tool recommended by the Cochrane Collaboration. Statistical analysis included the individual and combined result of the studies, heterogeneity test, the effect size, sensitivity analysis, and publication bias tests.
Five randomised controlled trials (RCTs) with a total of 411 patients were included in this study. This meta-analysis showed a higher rate of complete ulcer healing in groups receiving fish skin grafts (OR = 3.34, 95% CI 2.14–5.20, p |
| doi_str_mv | 10.1016/j.pcd.2024.03.008 |
| format | Article |
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The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing. The risk of bias assessment was conducted using the tool recommended by the Cochrane Collaboration. Statistical analysis included the individual and combined result of the studies, heterogeneity test, the effect size, sensitivity analysis, and publication bias tests.
Five randomised controlled trials (RCTs) with a total of 411 patients were included in this study. This meta-analysis showed a higher rate of complete ulcer healing in groups receiving fish skin grafts (OR = 3.34, 95% CI 2.14–5.20, p < 0.01, I2 = 0%) compared to control groups.
Fish skin grafts have been shown to be more effective for achieving complete ulcer healing compared to current conventional treatments in diabetic foot disease.
•Foot complications are one of the leading causes of hospitalisation in patients with diabetes mellitus, demanding prolonged stays.•15% of the diabetic population will develop diabetic foot disease during their disease, with 25% of them leading to lower limb amputation.•The current standard hospital treatments for patients with diabetic foot disease, do not guarantee success in their closure.•Fish skin grafts is a highly efficient treatment considering its cost and effectiveness in the ability to stimulate cell proliferation and differentiation.</description><identifier>ISSN: 1751-9918</identifier><identifier>ISSN: 1878-0210</identifier><identifier>EISSN: 1878-0210</identifier><identifier>DOI: 10.1016/j.pcd.2024.03.008</identifier><identifier>PMID: 38644082</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Animals ; Chronic Disease ; Diabetic Foot - diagnosis ; Diabetic Foot - therapy ; Diabetic foot disease ; Female ; Fish skin grafts ; Fishes ; Humans ; Male ; Meta-analysis ; Middle Aged ; Randomised controlled trials ; Randomized Controlled Trials as Topic ; Risk Factors ; Skin Transplantation ; Standard of Care ; Time Factors ; Treatment Outcome ; Ulcer treatment ; Wound Healing</subject><ispartof>Primary care diabetes, 2024-06, Vol.18 (3), p.291-298</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-7efa672ee3dbf6b1e27b95328b674cf31c0443de9f75dc89e00dba59619c46583</cites><orcidid>0000-0002-8981-1680 ; 0000-0003-3075-4164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pcd.2024.03.008$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38644082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz-Muñoz, Maria</creatorcontrib><creatorcontrib>Martinez-Barrios, Francisco-Javier</creatorcontrib><creatorcontrib>Cervera-Garvi, Pablo</creatorcontrib><creatorcontrib>Lopezosa-Reca, Eva</creatorcontrib><creatorcontrib>Marchena-Rodriguez, Ana J.</creatorcontrib><title>Fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: A systematic review and meta-analysis</title><title>Primary care diabetes</title><addtitle>Prim Care Diabetes</addtitle><description>This study will explore the effectiveness of fish skin grafts (FSG) in ulcer healing in diabetic foot disease compared to standard of care (SOC).
The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing. The risk of bias assessment was conducted using the tool recommended by the Cochrane Collaboration. Statistical analysis included the individual and combined result of the studies, heterogeneity test, the effect size, sensitivity analysis, and publication bias tests.
Five randomised controlled trials (RCTs) with a total of 411 patients were included in this study. This meta-analysis showed a higher rate of complete ulcer healing in groups receiving fish skin grafts (OR = 3.34, 95% CI 2.14–5.20, p < 0.01, I2 = 0%) compared to control groups.
Fish skin grafts have been shown to be more effective for achieving complete ulcer healing compared to current conventional treatments in diabetic foot disease.
•Foot complications are one of the leading causes of hospitalisation in patients with diabetes mellitus, demanding prolonged stays.•15% of the diabetic population will develop diabetic foot disease during their disease, with 25% of them leading to lower limb amputation.•The current standard hospital treatments for patients with diabetic foot disease, do not guarantee success in their closure.•Fish skin grafts is a highly efficient treatment considering its cost and effectiveness in the ability to stimulate cell proliferation and differentiation.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Chronic Disease</subject><subject>Diabetic Foot - diagnosis</subject><subject>Diabetic Foot - therapy</subject><subject>Diabetic foot disease</subject><subject>Female</subject><subject>Fish skin grafts</subject><subject>Fishes</subject><subject>Humans</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Randomised controlled trials</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Factors</subject><subject>Skin Transplantation</subject><subject>Standard of Care</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ulcer treatment</subject><subject>Wound Healing</subject><issn>1751-9918</issn><issn>1878-0210</issn><issn>1878-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhq0K1C_4AVyQj1wS7NiJHThVFS1IlbjA2XLsSddLEi8ep9Xe-On1dgtHTjPSvO8jzUPIO85qznj3cVvvnK8b1siaiZoxfULOuVa6Yg1nr8quWl71Pddn5AJxy1jHhVan5EzoTkqmm3Py5ybghuKvsND7ZMeM9AESrkgx28Xb5GkcqbMJaFzoY1wXTzdgp7DcPx82KS7BUR_sALksY4yZrpMrjE_0iuIeM8z2cEnwEOCRFiidIdvKLnbaY8A35PVoJ4S3L_OS_Lz58uP6a3X3_fbb9dVd5YTUuVIw2k41AMIPYzdwaNTQt6LRQ6ekGwV3TErhoR9V653ugTE_2LbveO9k12pxST4cubsUf6-A2cwBHUyTXSCuaASTQqm-kbxE-THqUkRMMJpdCrNNe8OZOYg3W1PEm4N4w4Qp4kvn_Qt-HWbw_xp_TZfA52MAypNFRTLoAiwOfEjgsvEx_Af_BCtqlUE</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Ruiz-Muñoz, Maria</creator><creator>Martinez-Barrios, Francisco-Javier</creator><creator>Cervera-Garvi, Pablo</creator><creator>Lopezosa-Reca, Eva</creator><creator>Marchena-Rodriguez, Ana J.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8981-1680</orcidid><orcidid>https://orcid.org/0000-0003-3075-4164</orcidid></search><sort><creationdate>202406</creationdate><title>Fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: A systematic review and meta-analysis</title><author>Ruiz-Muñoz, Maria ; Martinez-Barrios, Francisco-Javier ; Cervera-Garvi, Pablo ; Lopezosa-Reca, Eva ; Marchena-Rodriguez, Ana J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-7efa672ee3dbf6b1e27b95328b674cf31c0443de9f75dc89e00dba59619c46583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Chronic Disease</topic><topic>Diabetic Foot - diagnosis</topic><topic>Diabetic Foot - therapy</topic><topic>Diabetic foot disease</topic><topic>Female</topic><topic>Fish skin grafts</topic><topic>Fishes</topic><topic>Humans</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Randomised controlled trials</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Factors</topic><topic>Skin Transplantation</topic><topic>Standard of Care</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ulcer treatment</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz-Muñoz, Maria</creatorcontrib><creatorcontrib>Martinez-Barrios, Francisco-Javier</creatorcontrib><creatorcontrib>Cervera-Garvi, Pablo</creatorcontrib><creatorcontrib>Lopezosa-Reca, Eva</creatorcontrib><creatorcontrib>Marchena-Rodriguez, Ana J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Primary care diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz-Muñoz, Maria</au><au>Martinez-Barrios, Francisco-Javier</au><au>Cervera-Garvi, Pablo</au><au>Lopezosa-Reca, Eva</au><au>Marchena-Rodriguez, Ana J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: A systematic review and meta-analysis</atitle><jtitle>Primary care diabetes</jtitle><addtitle>Prim Care Diabetes</addtitle><date>2024-06</date><risdate>2024</risdate><volume>18</volume><issue>3</issue><spage>291</spage><epage>298</epage><pages>291-298</pages><issn>1751-9918</issn><issn>1878-0210</issn><eissn>1878-0210</eissn><abstract>This study will explore the effectiveness of fish skin grafts (FSG) in ulcer healing in diabetic foot disease compared to standard of care (SOC).
The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing. The risk of bias assessment was conducted using the tool recommended by the Cochrane Collaboration. Statistical analysis included the individual and combined result of the studies, heterogeneity test, the effect size, sensitivity analysis, and publication bias tests.
Five randomised controlled trials (RCTs) with a total of 411 patients were included in this study. This meta-analysis showed a higher rate of complete ulcer healing in groups receiving fish skin grafts (OR = 3.34, 95% CI 2.14–5.20, p < 0.01, I2 = 0%) compared to control groups.
Fish skin grafts have been shown to be more effective for achieving complete ulcer healing compared to current conventional treatments in diabetic foot disease.
•Foot complications are one of the leading causes of hospitalisation in patients with diabetes mellitus, demanding prolonged stays.•15% of the diabetic population will develop diabetic foot disease during their disease, with 25% of them leading to lower limb amputation.•The current standard hospital treatments for patients with diabetic foot disease, do not guarantee success in their closure.•Fish skin grafts is a highly efficient treatment considering its cost and effectiveness in the ability to stimulate cell proliferation and differentiation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38644082</pmid><doi>10.1016/j.pcd.2024.03.008</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8981-1680</orcidid><orcidid>https://orcid.org/0000-0003-3075-4164</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Animals Chronic Disease Diabetic Foot - diagnosis Diabetic Foot - therapy Diabetic foot disease Female Fish skin grafts Fishes Humans Male Meta-analysis Middle Aged Randomised controlled trials Randomized Controlled Trials as Topic Risk Factors Skin Transplantation Standard of Care Time Factors Treatment Outcome Ulcer treatment Wound Healing |
| title | Fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: A systematic review and meta-analysis |
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