RNA editing and immune control: from mechanism to therapy

Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in labeling endogenous double-stranded RNAs (dsRNAs) as ‘self’, thereby averting their potential to activate innate immune respons...

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Veröffentlicht in:	Current opinion in genetics & development 2024-06, Vol.86, p.102195, Article 102195
Hauptverfasser:	Hu, Shi-Bin, Li, Jin Billy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Humans Immunity, Innate Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy RNA Editing RNA, Double-Stranded - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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