RNA editing and immune control: from mechanism to therapy
Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in labeling endogenous double-stranded RNAs (dsRNAs) as ‘self’, thereby averting their potential to activate innate immune respons...
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| Veröffentlicht in: | Current opinion in genetics & development 2024-06, Vol.86, p.102195, Article 102195 |
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| creator | Hu, Shi-Bin Li, Jin Billy |
| description | Adenosine-to-inosine RNA editing, catalyzed by the enzymes ADAR1 and ADAR2, stands as a pervasive RNA modification. A primary function of ADAR1-mediated RNA editing lies in labeling endogenous double-stranded RNAs (dsRNAs) as ‘self’, thereby averting their potential to activate innate immune responses. Recent findings have highlighted additional roles of ADAR1, independent of RNA editing, that are crucial for immune control. Here, we focus on recent progress in understanding ADAR1’s RNA editing–dependent and –independent roles in immune control. We describe how ADAR1 regulates various dsRNA innate immune receptors through distinct mechanisms. Furthermore, we discuss the implications of ADAR1 and RNA editing in diseases, including autoimmune diseases and cancers. |
| doi_str_mv | 10.1016/j.gde.2024.102195 |
| format | Article |
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| ispartof | Current opinion in genetics & development, 2024-06, Vol.86, p.102195, Article 102195 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Humans Immunity, Innate Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy RNA Editing RNA, Double-Stranded - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism |
| title | RNA editing and immune control: from mechanism to therapy |
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