C3 Dominant Collapsing Focal Segmental Glomerulosclerosis - A Report of Two Rare Cases

C3 Dominant Collapsing Focal Segmental Glomerulosclerosis - A Report of Two Rare Cases

Collapsing focal segmental glomerulosclerosis (FSGS) a heterogeneous group of disorders, rather than a single disease entity. Kidney biopsy shows segmental or globally collapsed, sclerotic glomerular capillaries. There is also hypertrophy and hyperplasia of overlying glomerular epithelial cells. Imm...

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Veröffentlicht in:Indian journal of nephrology 2024, Vol.34 (1), p.70-73
Hauptverfasser: Shankar, Mythri, Gurusiddiah, Sreedhara C, Vinay, K S, Aralapuram, Kishan, Siddalingappa, Ranjitha, Satheesh, Gouri
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container_end_page 73
container_issue 1
container_start_page 70
container_title Indian journal of nephrology
container_volume 34
creator Shankar, Mythri
Gurusiddiah, Sreedhara C
Vinay, K S
Aralapuram, Kishan
Siddalingappa, Ranjitha
Satheesh, Gouri
description Collapsing focal segmental glomerulosclerosis (FSGS) a heterogeneous group of disorders, rather than a single disease entity. Kidney biopsy shows segmental or globally collapsed, sclerotic glomerular capillaries. There is also hypertrophy and hyperplasia of overlying glomerular epithelial cells. Immuno-fluorescence is negative or has non-specific deposits of immunoglobulins and C3. We present two cases of C3 dominant collapsing FSGS. Both the cases were non-responsive to therapy and had a poor outcome. This calls for research to study the role of the complement pathway in the pathogenesis of FSGS.
doi_str_mv 10.4103/ijn.ijn_250_22
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title C3 Dominant Collapsing Focal Segmental Glomerulosclerosis - A Report of Two Rare Cases
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