Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients
Purpose To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA). Materials and Methods In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesi...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2024-06, Vol.47 (6), p.762-770 |
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| creator | Chehrehgosha, Haleh Chegini, Hossein Heydari, Iraj Ebrahiminik, Hojat Salouti, Rambod Golzarian, Jafar |
| description | Purpose
To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA).
Materials and Methods
In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called “Nik jet dissection” which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed.
Results
A significant reduction in serum intact parathyroid hormone and calcium levels was observed 6 months after ablation, with a mean difference of − 83.4 ± 104.1 pg/mL,
p
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| doi_str_mv | 10.1007/s00270-024-03725-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3043077605</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3066135609</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-35558e926267decf0b20b6de66b74f0ed60be72fe484132b8f970a1d9413f63d3</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVIabZpv0AOwZBLL25HkjWye1tC_0GgJbTQm5CtUePgtTaS3LDfvtpsmkIPPYnh_d6TRo-xMw5vOIB-mwCEhhpEU4PUQtX3R2zFGylqaPHHMVsB103NleIn7EVKtwBctUI9ZyeyxYYjdivWX1s3Bh_pbqF52FXrfrJ5DHMVfPXVRptvdjGMrlo7msPGvquuKS1TTnvdliHHkLY05PEXVevZTrs0PmgIxZ5HmnN6yZ55OyV69Xiesu8f3n-7_FRfffn4-XJ9VQ9SYK6lUqqlTqBA7Wjw0Avo0RFirxsP5BB60sJT0zZcir71nQbLXVcmj9LJU_b6kLuNoWyTstmMaaBpsjOFJRkJjQStEVRBL_5Bb8MSy_P3FCKXCqErlDhQQ1kyRfJmG8eNjTvDwewbMIcGTGnAPDRg7ovp_DF66Tfknix_vrwA8gCkIs0_Kf69-z-xvwG_05D_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3066135609</pqid></control><display><type>article</type><title>Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chehrehgosha, Haleh ; Chegini, Hossein ; Heydari, Iraj ; Ebrahiminik, Hojat ; Salouti, Rambod ; Golzarian, Jafar</creator><creatorcontrib>Chehrehgosha, Haleh ; Chegini, Hossein ; Heydari, Iraj ; Ebrahiminik, Hojat ; Salouti, Rambod ; Golzarian, Jafar</creatorcontrib><description>Purpose
To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA).
Materials and Methods
In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called “Nik jet dissection” which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed.
Results
A significant reduction in serum intact parathyroid hormone and calcium levels was observed 6 months after ablation, with a mean difference of − 83.4 ± 104.1 pg/mL,
p
< 0.001, and − 0.29 ± 0.22 mmol/L,
p
< 0.001, respectively. Serum phosphorus levels increased significantly with a mean difference of 0.09 ± 0.19 mmol/L,
p
= 0.040 at the end of the follow up. We observed a significant volume reduction rate of parathyroid adenomas with 89 ± 20.8 percent,
p
< 0.001. Also, 51% of adenomas disappeared at the end of the follow up. In this study, two cases of hematoma and one case of transient hoarseness (grade 1 of the CIRSE classification) were encountered.
Conclusion
Our study showed that RFA with the alternative technique, called “Nik jet dissection” is a safe and effective modality in management of PTA. Therefore, we suggest expanding the indications for RFA in PTA management, especially when surgery is not feasible.
Level of Evidence
Level 3, Local non-random sample.
Graphical Abstract</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-024-03725-w</identifier><identifier>PMID: 38641669</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ablation ; Adenoma ; Adenoma - blood ; Adenoma - diagnostic imaging ; Adenoma - pathology ; Adenoma - surgery ; Adult ; Aged ; Cardiology ; Clinical Investigation ; Coagulation ; Dissection ; Female ; Hematoma ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Non-Vascular Interventions ; Nuclear Medicine ; Parathyroid hormone ; Parathyroid Hormone - blood ; Parathyroid Neoplasms - blood ; Parathyroid Neoplasms - diagnostic imaging ; Parathyroid Neoplasms - surgery ; Radio frequency ; Radiofrequency ablation ; Radiofrequency Ablation - methods ; Radiology ; Retrospective Studies ; Treatment Outcome ; Tumors ; Ultrasonography - methods ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2024-06, Vol.47 (6), p.762-770</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-35558e926267decf0b20b6de66b74f0ed60be72fe484132b8f970a1d9413f63d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-024-03725-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-024-03725-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38641669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chehrehgosha, Haleh</creatorcontrib><creatorcontrib>Chegini, Hossein</creatorcontrib><creatorcontrib>Heydari, Iraj</creatorcontrib><creatorcontrib>Ebrahiminik, Hojat</creatorcontrib><creatorcontrib>Salouti, Rambod</creatorcontrib><creatorcontrib>Golzarian, Jafar</creatorcontrib><title>Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA).
Materials and Methods
In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called “Nik jet dissection” which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed.
Results
A significant reduction in serum intact parathyroid hormone and calcium levels was observed 6 months after ablation, with a mean difference of − 83.4 ± 104.1 pg/mL,
p
< 0.001, and − 0.29 ± 0.22 mmol/L,
p
< 0.001, respectively. Serum phosphorus levels increased significantly with a mean difference of 0.09 ± 0.19 mmol/L,
p
= 0.040 at the end of the follow up. We observed a significant volume reduction rate of parathyroid adenomas with 89 ± 20.8 percent,
p
< 0.001. Also, 51% of adenomas disappeared at the end of the follow up. In this study, two cases of hematoma and one case of transient hoarseness (grade 1 of the CIRSE classification) were encountered.
Conclusion
Our study showed that RFA with the alternative technique, called “Nik jet dissection” is a safe and effective modality in management of PTA. Therefore, we suggest expanding the indications for RFA in PTA management, especially when surgery is not feasible.
Level of Evidence
Level 3, Local non-random sample.
Graphical Abstract</description><subject>Ablation</subject><subject>Adenoma</subject><subject>Adenoma - blood</subject><subject>Adenoma - diagnostic imaging</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Cardiology</subject><subject>Clinical Investigation</subject><subject>Coagulation</subject><subject>Dissection</subject><subject>Female</subject><subject>Hematoma</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Non-Vascular Interventions</subject><subject>Nuclear Medicine</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroid Neoplasms - blood</subject><subject>Parathyroid Neoplasms - diagnostic imaging</subject><subject>Parathyroid Neoplasms - surgery</subject><subject>Radio frequency</subject><subject>Radiofrequency ablation</subject><subject>Radiofrequency Ablation - methods</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVIabZpv0AOwZBLL25HkjWye1tC_0GgJbTQm5CtUePgtTaS3LDfvtpsmkIPPYnh_d6TRo-xMw5vOIB-mwCEhhpEU4PUQtX3R2zFGylqaPHHMVsB103NleIn7EVKtwBctUI9ZyeyxYYjdivWX1s3Bh_pbqF52FXrfrJ5DHMVfPXVRptvdjGMrlo7msPGvquuKS1TTnvdliHHkLY05PEXVevZTrs0PmgIxZ5HmnN6yZ55OyV69Xiesu8f3n-7_FRfffn4-XJ9VQ9SYK6lUqqlTqBA7Wjw0Avo0RFirxsP5BB60sJT0zZcir71nQbLXVcmj9LJU_b6kLuNoWyTstmMaaBpsjOFJRkJjQStEVRBL_5Bb8MSy_P3FCKXCqErlDhQQ1kyRfJmG8eNjTvDwewbMIcGTGnAPDRg7ovp_DF66Tfknix_vrwA8gCkIs0_Kf69-z-xvwG_05D_</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Chehrehgosha, Haleh</creator><creator>Chegini, Hossein</creator><creator>Heydari, Iraj</creator><creator>Ebrahiminik, Hojat</creator><creator>Salouti, Rambod</creator><creator>Golzarian, Jafar</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20240601</creationdate><title>Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients</title><author>Chehrehgosha, Haleh ; Chegini, Hossein ; Heydari, Iraj ; Ebrahiminik, Hojat ; Salouti, Rambod ; Golzarian, Jafar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-35558e926267decf0b20b6de66b74f0ed60be72fe484132b8f970a1d9413f63d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ablation</topic><topic>Adenoma</topic><topic>Adenoma - blood</topic><topic>Adenoma - diagnostic imaging</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Cardiology</topic><topic>Clinical Investigation</topic><topic>Coagulation</topic><topic>Dissection</topic><topic>Female</topic><topic>Hematoma</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Non-Vascular Interventions</topic><topic>Nuclear Medicine</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroid Neoplasms - blood</topic><topic>Parathyroid Neoplasms - diagnostic imaging</topic><topic>Parathyroid Neoplasms - surgery</topic><topic>Radio frequency</topic><topic>Radiofrequency ablation</topic><topic>Radiofrequency Ablation - methods</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chehrehgosha, Haleh</creatorcontrib><creatorcontrib>Chegini, Hossein</creatorcontrib><creatorcontrib>Heydari, Iraj</creatorcontrib><creatorcontrib>Ebrahiminik, Hojat</creatorcontrib><creatorcontrib>Salouti, Rambod</creatorcontrib><creatorcontrib>Golzarian, Jafar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chehrehgosha, Haleh</au><au>Chegini, Hossein</au><au>Heydari, Iraj</au><au>Ebrahiminik, Hojat</au><au>Salouti, Rambod</au><au>Golzarian, Jafar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>47</volume><issue>6</issue><spage>762</spage><epage>770</epage><pages>762-770</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA).
Materials and Methods
In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called “Nik jet dissection” which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed.
Results
A significant reduction in serum intact parathyroid hormone and calcium levels was observed 6 months after ablation, with a mean difference of − 83.4 ± 104.1 pg/mL,
p
< 0.001, and − 0.29 ± 0.22 mmol/L,
p
< 0.001, respectively. Serum phosphorus levels increased significantly with a mean difference of 0.09 ± 0.19 mmol/L,
p
= 0.040 at the end of the follow up. We observed a significant volume reduction rate of parathyroid adenomas with 89 ± 20.8 percent,
p
< 0.001. Also, 51% of adenomas disappeared at the end of the follow up. In this study, two cases of hematoma and one case of transient hoarseness (grade 1 of the CIRSE classification) were encountered.
Conclusion
Our study showed that RFA with the alternative technique, called “Nik jet dissection” is a safe and effective modality in management of PTA. Therefore, we suggest expanding the indications for RFA in PTA management, especially when surgery is not feasible.
Level of Evidence
Level 3, Local non-random sample.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38641669</pmid><doi>10.1007/s00270-024-03725-w</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Ablation Adenoma Adenoma - blood Adenoma - diagnostic imaging Adenoma - pathology Adenoma - surgery Adult Aged Cardiology Clinical Investigation Coagulation Dissection Female Hematoma Humans Imaging Male Medicine Medicine & Public Health Middle Aged Non-Vascular Interventions Nuclear Medicine Parathyroid hormone Parathyroid Hormone - blood Parathyroid Neoplasms - blood Parathyroid Neoplasms - diagnostic imaging Parathyroid Neoplasms - surgery Radio frequency Radiofrequency ablation Radiofrequency Ablation - methods Radiology Retrospective Studies Treatment Outcome Tumors Ultrasonography - methods Ultrasound |
| title | Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients |
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