Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins

T cell infiltration into tumors is a favorable prognostic feature, but most solid tumors lack productive T cell responses. Mechanisms that coordinate T cell exclusion are incompletely understood. Here we identify hepatocyte activation via interleukin-6/STAT3 and secretion of serum amyloid A (SAA) pr...

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Veröffentlicht in:	Nature immunology 2024-05, Vol.25 (5), p.755-763
Hauptverfasser:	Stone, Meredith L., Lee, Jesse, Lee, Jae W., Coho, Heather, Tariveranmoshabad, Mito, Wattenberg, Max M., Choi, Hana, Herrera, Veronica M., Xue, Yuqing, Choi-Bose, Shaanti, Zingone, Sofia K., Patel, Dhruv, Markowitz, Kelly, Delman, Devora, Balachandran, Vinod P., Beatty, Gregory L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1834 631/250/2161 631/67/580/1884 Adenocarcinoma Amyloid Animals Biomedical and Life Sciences Biomedicine Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Hepatocytes Hepatocytes - immunology Hepatocytes - metabolism Humans Immune response Immunology Infectious Diseases Infiltration Interleukin 6 Interleukin-6 - metabolism Letter Liver Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Metastases Mice Mice, Inbred C57BL Mice, Knockout Pancreas Pancreatic cancer Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Proteins Serum Amyloid A Protein - genetics Serum Amyloid A Protein - metabolism Signal Transduction Solid tumors Stat3 protein STAT3 Transcription Factor - metabolism Surgery Surveillance Toll-like receptors Tumor Escape Tumor microenvironment Tumor Microenvironment - immunology Tumors
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