Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors

[Display omitted] •The synthesis of C15AlkOPP was improved to produce multi-milligram amounts of the final diphosphate product.•The C15AlkOPP probe can be metabolically incorporated into various primary cells enriched via magnetic cell sorting.•Chemoproteomic analysis of prenylated proteins using C1...

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