Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunit

Gamma-aminobutyric acid A (GABA-A) receptors in the cells of the immune system enhance anti-inflammatory responses by regulating cytokine secretion, cytotoxic responses, and cell activation. In the CNS, the formation of GABA-A subunits into a pentameric structure has been extensively studied; howeve...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2024-07, Vol.241, p.106525, Article 106525
Hauptverfasser:	Hamidovic, Ajna, Cho, Soojeong, Davis, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allopregnanolone Dehydroepiandrosterone DHEA Estradiol - blood Female GABA-A receptor Gene Expression - drug effects Humans Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Peripheral blood mononuclear cells Pregnanolone - metabolism Progesterone - blood Receptors, GABA-A - genetics Receptors, GABA-A - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Young Adult δ Subunit
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