Cherubism Unmasked: A Case Report of Clinical and Histopathological Presentation

Cherubism Unmasked: A Case Report of Clinical and Histopathological Presentation

Cherubism, an uncommon genetic disorder, manifests as painless swelling in both jaws. A 20-year-old male presented with symmetrical swelling in both the mandible and maxilla. The jaws exhibited bilateral expansion, typical of this condition. Dentofacial abnormalities associated with cherubism stem f...

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Veröffentlicht in:Cureus 2024, Vol.16 (3), p.e56456-e56456
Hauptverfasser: Akolkar, Sakshi, Hande, Alka, Sonone, Archana M, Chavhan, Ankita, Tehzeeb, Husna
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container_title Cureus
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creator Akolkar, Sakshi
Hande, Alka
Sonone, Archana M
Chavhan, Ankita
Tehzeeb, Husna
description Cherubism, an uncommon genetic disorder, manifests as painless swelling in both jaws. A 20-year-old male presented with symmetrical swelling in both the mandible and maxilla. The jaws exhibited bilateral expansion, typical of this condition. Dentofacial abnormalities associated with cherubism stem from mutations in the SH3BP2 gene, which plays a crucial role in regulating osteoblasts and osteoclasts. In summary, cherubism is a genetic disorder characterized by non-cancerous jaw bone lesions. Surgical intervention may be necessary for functional or aesthetic concerns.
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title Cherubism Unmasked: A Case Report of Clinical and Histopathological Presentation
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