The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation

Scope Bile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between...

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Veröffentlicht in:Molecular nutrition & food research 2024-05, Vol.68 (9), p.e2400147-n/a
Hauptverfasser: Jin, Mengcheng, Zou, Tangbin, Huang, Hairong, Chen, Ming, Zou, Haoqi, Chen, Baoyan, Lai, Chengze, Li, Huawen, Zhang, Peiwen
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container_end_page n/a
container_issue 9
container_start_page e2400147
container_title Molecular nutrition & food research
container_volume 68
creator Jin, Mengcheng
Zou, Tangbin
Huang, Hairong
Chen, Ming
Zou, Haoqi
Chen, Baoyan
Lai, Chengze
Li, Huawen
Zhang, Peiwen
description Scope Bile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between CoQ10 and bile acids has not yet been evaluated. Methods and results This study assesses the impact of CoQ10 treatment on bile acid metabolism in mice on a high‐fat diet using Ultra‐Performance Liquid Chromatography‐tandem Mass Spectrometry. CoQ10 reverses the reduction in serum and colonic total bile acid levels and alters the bile acid profile in mice that are caused by a high‐fat diet. Seventeen potential targets of CoQ10 in bile acid metabolism are identified by network pharmacology, with six being central to the mechanism. Molecular docking shows a high binding affinity of CoQ10 to five of these key targets. Further analyses indicate that farnesoid X (FXR) receptor and Takeda G‐protein coupled receptor 5 (TGR5) may be crucial targets for CoQ10 to regulate bile acid metabolism and exert beneficial effects. Conclusion This study sheds light on the impact of CoQ10 in bile acids metabolism and offers a new perspective on the application of CoQ10 in metabolic health. Coenzyme Q10 (CoQ10) regulates high‐fat diet‐induced bile acid (BA) metabolism in mice, mediated by activation of the FXR pathway and increased levels of BA in the intestine and blood. Intestinal BA activates the TGR5 pathway in intestinal L‐cells and promotes GLP‐1 release. In addition, blood BA activates TGR5 in brown adipose tissue and triggers increased UCP1.
doi_str_mv 10.1002/mnfr.202400147
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Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between CoQ10 and bile acids has not yet been evaluated. Methods and results This study assesses the impact of CoQ10 treatment on bile acid metabolism in mice on a high‐fat diet using Ultra‐Performance Liquid Chromatography‐tandem Mass Spectrometry. CoQ10 reverses the reduction in serum and colonic total bile acid levels and alters the bile acid profile in mice that are caused by a high‐fat diet. Seventeen potential targets of CoQ10 in bile acid metabolism are identified by network pharmacology, with six being central to the mechanism. Molecular docking shows a high binding affinity of CoQ10 to five of these key targets. Further analyses indicate that farnesoid X (FXR) receptor and Takeda G‐protein coupled receptor 5 (TGR5) may be crucial targets for CoQ10 to regulate bile acid metabolism and exert beneficial effects. Conclusion This study sheds light on the impact of CoQ10 in bile acids metabolism and offers a new perspective on the application of CoQ10 in metabolic health. Coenzyme Q10 (CoQ10) regulates high‐fat diet‐induced bile acid (BA) metabolism in mice, mediated by activation of the FXR pathway and increased levels of BA in the intestine and blood. Intestinal BA activates the TGR5 pathway in intestinal L‐cells and promotes GLP‐1 release. In addition, blood BA activates TGR5 in brown adipose tissue and triggers increased UCP1.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202400147</identifier><identifier>PMID: 38643378</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acids ; Bile ; Bile acids ; bile acids metabolism ; Coenzyme Q10 ; Diet ; Energy balance ; FXR ; High fat diet ; Homeostasis ; Lipids ; Lipophilic ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Metabolic disorders ; Metabolism ; Molecular docking ; network pharmacology ; Pharmacology ; Receptors ; TGR5</subject><ispartof>Molecular nutrition &amp; food research, 2024-05, Vol.68 (9), p.e2400147-n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3232-4dd91b025fb1eaa1e1e2e6f59148cb63bf9716b44af4c00b6cb05675c9c4dd23</cites><orcidid>0009-0008-1255-9668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202400147$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202400147$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38643378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Mengcheng</creatorcontrib><creatorcontrib>Zou, Tangbin</creatorcontrib><creatorcontrib>Huang, Hairong</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><creatorcontrib>Zou, Haoqi</creatorcontrib><creatorcontrib>Chen, Baoyan</creatorcontrib><creatorcontrib>Lai, Chengze</creatorcontrib><creatorcontrib>Li, Huawen</creatorcontrib><creatorcontrib>Zhang, Peiwen</creatorcontrib><title>The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation</title><title>Molecular nutrition &amp; food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope Bile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between CoQ10 and bile acids has not yet been evaluated. Methods and results This study assesses the impact of CoQ10 treatment on bile acid metabolism in mice on a high‐fat diet using Ultra‐Performance Liquid Chromatography‐tandem Mass Spectrometry. CoQ10 reverses the reduction in serum and colonic total bile acid levels and alters the bile acid profile in mice that are caused by a high‐fat diet. Seventeen potential targets of CoQ10 in bile acid metabolism are identified by network pharmacology, with six being central to the mechanism. Molecular docking shows a high binding affinity of CoQ10 to five of these key targets. Further analyses indicate that farnesoid X (FXR) receptor and Takeda G‐protein coupled receptor 5 (TGR5) may be crucial targets for CoQ10 to regulate bile acid metabolism and exert beneficial effects. Conclusion This study sheds light on the impact of CoQ10 in bile acids metabolism and offers a new perspective on the application of CoQ10 in metabolic health. Coenzyme Q10 (CoQ10) regulates high‐fat diet‐induced bile acid (BA) metabolism in mice, mediated by activation of the FXR pathway and increased levels of BA in the intestine and blood. Intestinal BA activates the TGR5 pathway in intestinal L‐cells and promotes GLP‐1 release. In addition, blood BA activates TGR5 in brown adipose tissue and triggers increased UCP1.</description><subject>Acids</subject><subject>Bile</subject><subject>Bile acids</subject><subject>bile acids metabolism</subject><subject>Coenzyme Q10</subject><subject>Diet</subject><subject>Energy balance</subject><subject>FXR</subject><subject>High fat diet</subject><subject>Homeostasis</subject><subject>Lipids</subject><subject>Lipophilic</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Molecular docking</subject><subject>network pharmacology</subject><subject>Pharmacology</subject><subject>Receptors</subject><subject>TGR5</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhi0EoiVw5YgsceHQBH_tbpZbG1Ko1JSviOvK9o4Tt157sXdVwg_h9-I2JQcuSCPNHJ555-NF6CUlM0oIe9t5E2eMMEEIFdUjdExLyqeCcv74ULPiCD1L6ZoQTpngT9ERn5eC82p-jH6vt4CXxoAecDB4EcD_2nWAv1CCv41976ADP8jBBo9znFkH-FTbFq9gkCo4m7p3-MInu9kOCZsYOnwFw22IN_jzVsZO6uDCZneCV8GBHp2M-H3QN9ZvTrD0LV7-7CHa-xkOf5fOtveznqMnRroELx7yBK3Pl-vFx-nlpw8Xi9PLqeaMs6lo25oqwgqjKEhJgQKD0hQ1FXOtSq5MXdFSCSGN0ISoUitSlFWha51bGZ-gN3vZPoYfI6Sh6WzS4Jz0EMbUcCI4qVid0wS9_ge9DmP0eblMFZyLef5npmZ7SseQUgTT9Pk6GXcNJc2dYc2dYc3BsNzw6kF2VB20B_yvQxkQe-A2v373H7lmdXX-VVQF438A_-eiaA</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Jin, Mengcheng</creator><creator>Zou, Tangbin</creator><creator>Huang, Hairong</creator><creator>Chen, Ming</creator><creator>Zou, Haoqi</creator><creator>Chen, Baoyan</creator><creator>Lai, Chengze</creator><creator>Li, Huawen</creator><creator>Zhang, Peiwen</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0008-1255-9668</orcidid></search><sort><creationdate>202405</creationdate><title>The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation</title><author>Jin, Mengcheng ; 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food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2024-05</date><risdate>2024</risdate><volume>68</volume><issue>9</issue><spage>e2400147</spage><epage>n/a</epage><pages>e2400147-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope Bile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between CoQ10 and bile acids has not yet been evaluated. Methods and results This study assesses the impact of CoQ10 treatment on bile acid metabolism in mice on a high‐fat diet using Ultra‐Performance Liquid Chromatography‐tandem Mass Spectrometry. CoQ10 reverses the reduction in serum and colonic total bile acid levels and alters the bile acid profile in mice that are caused by a high‐fat diet. Seventeen potential targets of CoQ10 in bile acid metabolism are identified by network pharmacology, with six being central to the mechanism. Molecular docking shows a high binding affinity of CoQ10 to five of these key targets. Further analyses indicate that farnesoid X (FXR) receptor and Takeda G‐protein coupled receptor 5 (TGR5) may be crucial targets for CoQ10 to regulate bile acid metabolism and exert beneficial effects. Conclusion This study sheds light on the impact of CoQ10 in bile acids metabolism and offers a new perspective on the application of CoQ10 in metabolic health. Coenzyme Q10 (CoQ10) regulates high‐fat diet‐induced bile acid (BA) metabolism in mice, mediated by activation of the FXR pathway and increased levels of BA in the intestine and blood. Intestinal BA activates the TGR5 pathway in intestinal L‐cells and promotes GLP‐1 release. In addition, blood BA activates TGR5 in brown adipose tissue and triggers increased UCP1.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38643378</pmid><doi>10.1002/mnfr.202400147</doi><tpages>12</tpages><orcidid>https://orcid.org/0009-0008-1255-9668</orcidid></addata></record>
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subjects Acids
Bile
Bile acids
bile acids metabolism
Coenzyme Q10
Diet
Energy balance
FXR
High fat diet
Homeostasis
Lipids
Lipophilic
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolic disorders
Metabolism
Molecular docking
network pharmacology
Pharmacology
Receptors
TGR5
title The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation
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