HLM chip – A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes

•Microfabricated flow-through assays enable the study of time-dependent drug responses.•Microfluidic HLM chips have enzyme kinetics comparable to static enzyme incubations.•Microfluidic HLM chips enable facile identification of irreversible enzyme inhibitors.•HLM chip assays suggest that miconazole...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2024-06, Vol.197, p.106773-106773, Article 106773
Hauptverfasser:	Pihlaja, Tea, Kiiski, Iiro, Sikanen, Tiina
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytochrome P-450 CYP2C9 - metabolism Cytochrome P-450 CYP2C9 Inhibitors - pharmacology Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome p450 Drug metabolism Enzyme immobilization Enzyme inhibition Enzymes, Immobilized - metabolism Humans Kinetics Lab-On-A-Chip Devices Miconazole - pharmacology Microfluidic Analytical Techniques - methods Microfluidics Microfluidics - methods Microsomal binding Microsomes, Liver - metabolism Sulfaphenazole - pharmacology
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