Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway

Post-traumatic stress disorder (PTSD) refers to a chronic impairing psychiatric disorder occurring after exposure to the severe traumatic event. Studies have demonstrated that medicinal cannabis oil plays an important role in neuroprotection, but the mechanism by which it exerts anti-PTSD effects re...

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Veröffentlicht in:	Behavioural brain research 2024-06, Vol.467, p.115005, Article 115005
Hauptverfasser:	Shen, Baoying, Wang, Zhixing, Yu, Huijing, Shen, Xin, Li, Lin, Ru, Yi, Yang, Chunqi, Du, Guangxu, Lai, Chengcai, Gao, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - drug therapy Anxiety - metabolism Apoptosis - drug effects BDNF Behavior, Animal - drug effects Brain-Derived Neurotrophic Factor - drug effects Brain-Derived Neurotrophic Factor - metabolism Chronic complex stress Depression - drug therapy Depression - metabolism Disease Models, Animal Hippocampus - drug effects Hippocampus - metabolism Male Medical Marijuana - pharmacology Medicinal cannabis oil Mice Mice, Inbred C57BL Plant Oils - administration & dosage Plant Oils - pharmacology Post-traumatic stress disorder Signal Transduction - drug effects Stress Disorders, Post-Traumatic - drug therapy Stress Disorders, Post-Traumatic - metabolism Stress, Psychological - drug therapy Stress, Psychological - metabolism TRPC6 TRPC6 Cation Channel - metabolism
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