Lower malathion concentrations reduce testosterone biosynthesis by Leydig TM3 cells in vitro by altering cellular redox profile and inducing oxidative damage

Malathion is an organophosphate pesticide used in agriculture and control of the Aedes aegypti mosquito. As previous reports have indicated the potential of malathion to compromise testosterone production in in vivo models, the objective of this study was to elucidate the mechanisms underlying the i...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2024-06, Vol.126, p.108595, Article 108595
Hauptverfasser:	Erthal-Michelato, Rafaela Pires, Quadreli, Débora Hipólito, Zaninelli, Tiago Henrique, Verri, Waldiceu Aparecido, Fernandes, Glaura Scantamburlo Alves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Cell Line Cell Survival - drug effects Cytokines Cytokines - metabolism Endocrine disruptors Insecticides - toxicity Leydig Cells - drug effects Leydig Cells - metabolism Malathion Malathion - toxicity Male Mice Oxidation-Reduction Oxidative stress Oxidative Stress - drug effects Steroidogenesis Testosterone Testosterone - biosynthesis TM3
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