Positron emission tomography guided synergistic treatment of melanoma using multifunctional zirconium-hematoporphyrin nanosonosensitizers

Sonodynamic therapy (SDT) has emerged as a useful approach for tumor treatment. However, its widespread application is impeded by poor pharmacokinetics of existing sonosensitizers. Here we developed a metal-organic nanoplatform, wherein a small-molecule sonosensitizer (hematoporphyrin monomethyl eth...

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Veröffentlicht in:	Journal of controlled release 2024-06, Vol.370, p.95-109
Hauptverfasser:	Jiao, Xiaodan, Li, Xiaoyang, Du, Yan, Cong, Yiyang, Yang, Shuyang, Chen, Daiqin, Zhang, Tao, Feng, Min, Hong, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Drug delivery Female Hematoporphyrins - administration & dosage Hematoporphyrins - chemistry Hematoporphyrins - pharmacokinetics Immune activation Melanoma - diagnostic imaging Melanoma - drug therapy Melanoma, Experimental - diagnostic imaging Melanoma, Experimental - therapy Metal-organic nanoplatform Mice Mice, Inbred C57BL Nanoparticles - chemistry Positron emission tomography Positron-Emission Tomography - methods Radioisotopes - administration & dosage Sonodynamic therapy Ultrasonic Therapy - methods Zirconium - chemistry Zirconium - pharmacokinetics
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