Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders
[Display omitted] Delivering drugs to the brain is a complex challenge in medical research, particularly for disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of many therapeutic molecules, hindering their effectiveness. Nanoparticles, a potential solu...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2024-06, Vol.199, p.114298-114298, Article 114298 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
| container_volume | 199 |
| creator | Yadav, Krishna Vijayalakshmi, R. Kumar Sahu, Kantrol Sure, Pavani Chahal, Kavita Yadav, Renu Sucheta Dubey, Akhilesh Jha, Megha Pradhan, Madhulika |
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Delivering drugs to the brain is a complex challenge in medical research, particularly for disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of many therapeutic molecules, hindering their effectiveness. Nanoparticles, a potential solution, face issues like toxicity and limited approvals. A new avenue explores the use of small extracellular vesicles (sEVs), i.e., exosomes, as natural carriers for drug delivery. sEVs, tiny structures below 150 nm, show promise due to their minimal immune response and ability to precisely deliver drugs. This review focuses on the potential of sEVs-based drug delivery systems for treating neurological disorders, brain cancers, and other brain-related issues. Notably, bioengineered sEVs-carrying therapeutic compounds exhibit promise in early studies. The unique features of sEVs, such as their small size and natural properties, position them as candidates to overcome challenges in drug delivery to the brain. Ongoing clinical trials and research into sEVs behavior within the body further highlight their potential for revolutionizing drug delivery and addressing complex brain conditions. |
| doi_str_mv | 10.1016/j.ejpb.2024.114298 |
| format | Article |
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Delivering drugs to the brain is a complex challenge in medical research, particularly for disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of many therapeutic molecules, hindering their effectiveness. Nanoparticles, a potential solution, face issues like toxicity and limited approvals. A new avenue explores the use of small extracellular vesicles (sEVs), i.e., exosomes, as natural carriers for drug delivery. sEVs, tiny structures below 150 nm, show promise due to their minimal immune response and ability to precisely deliver drugs. This review focuses on the potential of sEVs-based drug delivery systems for treating neurological disorders, brain cancers, and other brain-related issues. Notably, bioengineered sEVs-carrying therapeutic compounds exhibit promise in early studies. The unique features of sEVs, such as their small size and natural properties, position them as candidates to overcome challenges in drug delivery to the brain. Ongoing clinical trials and research into sEVs behavior within the body further highlight their potential for revolutionizing drug delivery and addressing complex brain conditions.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2024.114298</identifier><identifier>PMID: 38642716</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - metabolism ; Blood–brain barrier ; Brain - drug effects ; Brain - metabolism ; Brain Diseases - drug therapy ; Brain disorders ; Drug Carriers - chemistry ; Drug delivery ; Drug Delivery Systems - methods ; Exosomes ; Exosomes - metabolism ; Extracellular vesicles ; Humans ; Nanoparticles - chemistry ; Neurotherapeutic</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2024-06, Vol.199, p.114298-114298, Article 114298</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3598d65348aa0af8d5af1909f4daa1a51b752ad406dfbb923affd151cbc6593a3</citedby><cites>FETCH-LOGICAL-c356t-3598d65348aa0af8d5af1909f4daa1a51b752ad406dfbb923affd151cbc6593a3</cites><orcidid>0000-0001-7996-4563</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939641124001243$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38642716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadav, Krishna</creatorcontrib><creatorcontrib>Vijayalakshmi, R.</creatorcontrib><creatorcontrib>Kumar Sahu, Kantrol</creatorcontrib><creatorcontrib>Sure, Pavani</creatorcontrib><creatorcontrib>Chahal, Kavita</creatorcontrib><creatorcontrib>Yadav, Renu</creatorcontrib><creatorcontrib>Sucheta</creatorcontrib><creatorcontrib>Dubey, Akhilesh</creatorcontrib><creatorcontrib>Jha, Megha</creatorcontrib><creatorcontrib>Pradhan, Madhulika</creatorcontrib><title>Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>[Display omitted]
Delivering drugs to the brain is a complex challenge in medical research, particularly for disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of many therapeutic molecules, hindering their effectiveness. Nanoparticles, a potential solution, face issues like toxicity and limited approvals. A new avenue explores the use of small extracellular vesicles (sEVs), i.e., exosomes, as natural carriers for drug delivery. sEVs, tiny structures below 150 nm, show promise due to their minimal immune response and ability to precisely deliver drugs. This review focuses on the potential of sEVs-based drug delivery systems for treating neurological disorders, brain cancers, and other brain-related issues. Notably, bioengineered sEVs-carrying therapeutic compounds exhibit promise in early studies. The unique features of sEVs, such as their small size and natural properties, position them as candidates to overcome challenges in drug delivery to the brain. Ongoing clinical trials and research into sEVs behavior within the body further highlight their potential for revolutionizing drug delivery and addressing complex brain conditions.</description><subject>Animals</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Blood–brain barrier</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain Diseases - drug therapy</subject><subject>Brain disorders</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Exosomes</subject><subject>Exosomes - metabolism</subject><subject>Extracellular vesicles</subject><subject>Humans</subject><subject>Nanoparticles - chemistry</subject><subject>Neurotherapeutic</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCILgt_gAPykUsWO3ayscSFrcqHVMQFztbEHrdeJXEYJ1X7E_jXeNnCkdNI8z408x5jr6XYSSHbd8cdHud-V4ta76TUtemesI3s9qpSWsunbCOMMlWrpbxgL3I-CiH0vumeswvVtbrey3bDfl3dp5xGrA6Q0fOv4CiNaUC3DkB8wpXScosEM65LdNzTesM9DvEO6YHDPFMCd4uZx4mnsnNpjNMNLxJ-GFLy1YGgQD0QRSQeEvGFEJYTqf8D-ZgTeaT8kj0LMGR89Ti37MfHq--Xn6vrb5--XH64rpxq2qVSjel82yjdAQgInW8gSCNM0B5AQiP7fVOD16L1oe9NrSAELxvpetc2RoHasrdn33L7zxXzYseYHQ4DTJjWbJXQSrRGlPC2rD5TSyg5EwY7UxyBHqwU9lSBPdpTBfZUgT1XUERvHv3XfkT_T_I380J4fyZg-fKuxGKzizg59JHQLdan-D__38d3m3s</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Yadav, Krishna</creator><creator>Vijayalakshmi, R.</creator><creator>Kumar Sahu, Kantrol</creator><creator>Sure, Pavani</creator><creator>Chahal, Kavita</creator><creator>Yadav, Renu</creator><creator>Sucheta</creator><creator>Dubey, Akhilesh</creator><creator>Jha, Megha</creator><creator>Pradhan, Madhulika</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7996-4563</orcidid></search><sort><creationdate>202406</creationdate><title>Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders</title><author>Yadav, Krishna ; Vijayalakshmi, R. ; Kumar Sahu, Kantrol ; Sure, Pavani ; Chahal, Kavita ; Yadav, Renu ; Sucheta ; Dubey, Akhilesh ; Jha, Megha ; Pradhan, Madhulika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-3598d65348aa0af8d5af1909f4daa1a51b752ad406dfbb923affd151cbc6593a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Blood–brain barrier</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain Diseases - drug therapy</topic><topic>Brain disorders</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>Exosomes</topic><topic>Exosomes - metabolism</topic><topic>Extracellular vesicles</topic><topic>Humans</topic><topic>Nanoparticles - chemistry</topic><topic>Neurotherapeutic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yadav, Krishna</creatorcontrib><creatorcontrib>Vijayalakshmi, R.</creatorcontrib><creatorcontrib>Kumar Sahu, Kantrol</creatorcontrib><creatorcontrib>Sure, Pavani</creatorcontrib><creatorcontrib>Chahal, Kavita</creatorcontrib><creatorcontrib>Yadav, Renu</creatorcontrib><creatorcontrib>Sucheta</creatorcontrib><creatorcontrib>Dubey, Akhilesh</creatorcontrib><creatorcontrib>Jha, Megha</creatorcontrib><creatorcontrib>Pradhan, Madhulika</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yadav, Krishna</au><au>Vijayalakshmi, R.</au><au>Kumar Sahu, Kantrol</au><au>Sure, Pavani</au><au>Chahal, Kavita</au><au>Yadav, Renu</au><au>Sucheta</au><au>Dubey, Akhilesh</au><au>Jha, Megha</au><au>Pradhan, Madhulika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2024-06</date><risdate>2024</risdate><volume>199</volume><spage>114298</spage><epage>114298</epage><pages>114298-114298</pages><artnum>114298</artnum><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>[Display omitted]
Delivering drugs to the brain is a complex challenge in medical research, particularly for disorders like Alzheimer's and Parkinson's. The blood–brain barrier restricts the entry of many therapeutic molecules, hindering their effectiveness. Nanoparticles, a potential solution, face issues like toxicity and limited approvals. A new avenue explores the use of small extracellular vesicles (sEVs), i.e., exosomes, as natural carriers for drug delivery. sEVs, tiny structures below 150 nm, show promise due to their minimal immune response and ability to precisely deliver drugs. This review focuses on the potential of sEVs-based drug delivery systems for treating neurological disorders, brain cancers, and other brain-related issues. Notably, bioengineered sEVs-carrying therapeutic compounds exhibit promise in early studies. The unique features of sEVs, such as their small size and natural properties, position them as candidates to overcome challenges in drug delivery to the brain. Ongoing clinical trials and research into sEVs behavior within the body further highlight their potential for revolutionizing drug delivery and addressing complex brain conditions.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38642716</pmid><doi>10.1016/j.ejpb.2024.114298</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7996-4563</orcidid></addata></record> |
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| subjects | Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood–brain barrier Brain - drug effects Brain - metabolism Brain Diseases - drug therapy Brain disorders Drug Carriers - chemistry Drug delivery Drug Delivery Systems - methods Exosomes Exosomes - metabolism Extracellular vesicles Humans Nanoparticles - chemistry Neurotherapeutic |
| title | Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders |
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