Vitamin D status of pregnant women with obesity in the UK and its association with pregnancy outcomes: a secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT) study
Prenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial, we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI ≥ 30 kg/m2) from multi-...
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Veröffentlicht in: | British journal of nutrition 2024-07, Vol.132 (1), p.40-49 |
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description | Prenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial, we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI ≥ 30 kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17 ± 1 weeks’ gestation were assessed using multivariable linear regression and reported as percent differences in serum 25-hydroxyvitamin D (25(OH)D). Associations between 25(OH)D and clinical outcomes were examined using logistic regression. Among 1089 participants, 67 % had 25(OH)D < 50 nmol/l and 26 % had concentrations < 25 nmol/l. In fully adjusted models accounting for socio-demographic and anthropometric characteristics, 25(OH)D was lower among women of Black (% difference = −33; 95 % CI: −39, −27), Asian (% difference = −43; 95 % CI: −51, −35) and other non-White (% difference = −26; 95 % CI: −35, −14) ethnicity compared with women of White ethnicity (n 1086; P < 0·001 for all). In unadjusted analysis, risk of gestational diabetes was greater in women with 25(OH)D < 25 nmol/l compared with ≥ 50 nmol/l (OR = 1·58; 95 % CI: 1·09, 2·31), but the magnitude of effect estimates was attenuated in the multivariable model (OR = 1·33; 95 % CI: 0·88, 2·00). There were no associations between 25(OH)D and risk of preeclampsia, preterm birth or small for gestational age or large-for-gestational-age delivery. These findings demonstrate low 25(OH)D among pregnant women with obesity and highlight ethnic disparities in vitamin D status in the UK. However, evidence for a greater risk of adverse perinatal outcomes among women with vitamin D deficiency was limited. |
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In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial, we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI ≥ 30 kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17 ± 1 weeks’ gestation were assessed using multivariable linear regression and reported as percent differences in serum 25-hydroxyvitamin D (25(OH)D). Associations between 25(OH)D and clinical outcomes were examined using logistic regression. Among 1089 participants, 67 % had 25(OH)D < 50 nmol/l and 26 % had concentrations < 25 nmol/l. In fully adjusted models accounting for socio-demographic and anthropometric characteristics, 25(OH)D was lower among women of Black (% difference = −33; 95 % CI: −39, −27), Asian (% difference = −43; 95 % CI: −51, −35) and other non-White (% difference = −26; 95 % CI: −35, −14) ethnicity compared with women of White ethnicity (n 1086; P < 0·001 for all). In unadjusted analysis, risk of gestational diabetes was greater in women with 25(OH)D < 25 nmol/l compared with ≥ 50 nmol/l (OR = 1·58; 95 % CI: 1·09, 2·31), but the magnitude of effect estimates was attenuated in the multivariable model (OR = 1·33; 95 % CI: 0·88, 2·00). There were no associations between 25(OH)D and risk of preeclampsia, preterm birth or small for gestational age or large-for-gestational-age delivery. These findings demonstrate low 25(OH)D among pregnant women with obesity and highlight ethnic disparities in vitamin D status in the UK. However, evidence for a greater risk of adverse perinatal outcomes among women with vitamin D deficiency was limited.</description><identifier>ISSN: 0007-1145</identifier><identifier>ISSN: 1475-2662</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114524000862</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>25-Hydroxyvitamin D ; Automation ; Blood pressure ; Calciferol ; Diabetes ; Diabetes mellitus ; Eating ; Ethnicity ; Gestational age ; Glucose ; Human and Clinical Nutrition ; Immunoassay ; Minority & ethnic groups ; Obesity ; Overweight ; Pre-eclampsia ; Pregnancy ; Pregnancy complications ; Premature birth ; Public health ; Secondary analysis ; Small for gestational age ; Sociodemographics ; Vitamin D ; Vitamin deficiency ; Womens health</subject><ispartof>British journal of nutrition, 2024-07, Vol.132 (1), p.40-49</ispartof><rights>The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c275t-a64dbc92d2cb45ee82bce2d11633d42dadd5ceca8972a394bfa8fbd44cdf22d43</cites><orcidid>0000-0002-5853-3796 ; 0000-0003-0958-6725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114524000862/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids></links><search><creatorcontrib>O’Callaghan, Karen M.</creatorcontrib><creatorcontrib>Nowak, Katarzyna G.</creatorcontrib><creatorcontrib>Dalrymple, Kathryn V.</creatorcontrib><creatorcontrib>Poston, Lucilla</creatorcontrib><creatorcontrib>Rigutto-Farebrother, Jessica</creatorcontrib><creatorcontrib>Quotah, Ola F.</creatorcontrib><creatorcontrib>White, Sara L.</creatorcontrib><creatorcontrib>Flynn, Angela C.</creatorcontrib><creatorcontrib>UPBEAT Consortium</creatorcontrib><title>Vitamin D status of pregnant women with obesity in the UK and its association with pregnancy outcomes: a secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT) study</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Prenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial, we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI ≥ 30 kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17 ± 1 weeks’ gestation were assessed using multivariable linear regression and reported as percent differences in serum 25-hydroxyvitamin D (25(OH)D). Associations between 25(OH)D and clinical outcomes were examined using logistic regression. Among 1089 participants, 67 % had 25(OH)D < 50 nmol/l and 26 % had concentrations < 25 nmol/l. In fully adjusted models accounting for socio-demographic and anthropometric characteristics, 25(OH)D was lower among women of Black (% difference = −33; 95 % CI: −39, −27), Asian (% difference = −43; 95 % CI: −51, −35) and other non-White (% difference = −26; 95 % CI: −35, −14) ethnicity compared with women of White ethnicity (n 1086; P < 0·001 for all). In unadjusted analysis, risk of gestational diabetes was greater in women with 25(OH)D < 25 nmol/l compared with ≥ 50 nmol/l (OR = 1·58; 95 % CI: 1·09, 2·31), but the magnitude of effect estimates was attenuated in the multivariable model (OR = 1·33; 95 % CI: 0·88, 2·00). There were no associations between 25(OH)D and risk of preeclampsia, preterm birth or small for gestational age or large-for-gestational-age delivery. These findings demonstrate low 25(OH)D among pregnant women with obesity and highlight ethnic disparities in vitamin D status in the UK. However, evidence for a greater risk of adverse perinatal outcomes among women with vitamin D deficiency was limited.</description><subject>25-Hydroxyvitamin D</subject><subject>Automation</subject><subject>Blood pressure</subject><subject>Calciferol</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Eating</subject><subject>Ethnicity</subject><subject>Gestational age</subject><subject>Glucose</subject><subject>Human and Clinical Nutrition</subject><subject>Immunoassay</subject><subject>Minority & ethnic groups</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pre-eclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Premature birth</subject><subject>Public health</subject><subject>Secondary analysis</subject><subject>Small for gestational age</subject><subject>Sociodemographics</subject><subject>Vitamin D</subject><subject>Vitamin deficiency</subject><subject>Womens health</subject><issn>0007-1145</issn><issn>1475-2662</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u1DAURi0EEsPAA7CzxKYsUmzH-WM3LUOpqNRKzLCNHPtm6iqJB1-HKo_Hm-G0kZCKurIln_N9ti8h7zk75YwXn34wxgrOZSZk3JW5eEFWXBZZIvJcvCSr-TiZz1-TN4h3M8NZtSJ_ftqgejvQLxSDCiNS19Kjh8OghkDvXQ8DvbfhlroG0IaJRjTcAt1_p2ow1AakCtFpq4J1C7roeqJuDDpG4GeqKIJ2g1F-iqLqJrQPVUvWzaJYQHoGIYCn25g4HB5aNjrY33P5zlvV0ZP9zdl2s_sYbzya6S151aoO4d2yrsn-63Z3_i25ur64PN9cJVoUWUhULk2jK2GEbmQGUIpGgzCc52lqpDDKmEyDVmVVCJVWsmlV2TZGSm1aIYxM1-TkMffo3a8RMNS9RQ1dpwZwI9Ypk1ykvBJlRD88Qe_c6OOrI8VZmbE8jbVrwh8p7R2ih7Y-etvHD6o5q-eh1v8NNTrp4qi-8dYc4F_089ZfTi-mlA</recordid><startdate>20240714</startdate><enddate>20240714</enddate><creator>O’Callaghan, Karen M.</creator><creator>Nowak, Katarzyna G.</creator><creator>Dalrymple, Kathryn V.</creator><creator>Poston, Lucilla</creator><creator>Rigutto-Farebrother, Jessica</creator><creator>Quotah, Ola F.</creator><creator>White, Sara L.</creator><creator>Flynn, Angela C.</creator><general>Cambridge University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5853-3796</orcidid><orcidid>https://orcid.org/0000-0003-0958-6725</orcidid></search><sort><creationdate>20240714</creationdate><title>Vitamin D status of pregnant women with obesity in the UK and its association with pregnancy outcomes: a secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT) study</title><author>O’Callaghan, Karen M. ; Nowak, Katarzyna G. ; Dalrymple, Kathryn V. ; Poston, Lucilla ; Rigutto-Farebrother, Jessica ; Quotah, Ola F. ; White, Sara L. ; Flynn, Angela C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-a64dbc92d2cb45ee82bce2d11633d42dadd5ceca8972a394bfa8fbd44cdf22d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Automation</topic><topic>Blood pressure</topic><topic>Calciferol</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Eating</topic><topic>Ethnicity</topic><topic>Gestational age</topic><topic>Glucose</topic><topic>Human and Clinical Nutrition</topic><topic>Immunoassay</topic><topic>Minority & ethnic groups</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Pre-eclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Premature birth</topic><topic>Public health</topic><topic>Secondary analysis</topic><topic>Small for gestational age</topic><topic>Sociodemographics</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O’Callaghan, Karen M.</creatorcontrib><creatorcontrib>Nowak, Katarzyna G.</creatorcontrib><creatorcontrib>Dalrymple, Kathryn V.</creatorcontrib><creatorcontrib>Poston, Lucilla</creatorcontrib><creatorcontrib>Rigutto-Farebrother, Jessica</creatorcontrib><creatorcontrib>Quotah, Ola F.</creatorcontrib><creatorcontrib>White, Sara L.</creatorcontrib><creatorcontrib>Flynn, Angela C.</creatorcontrib><creatorcontrib>UPBEAT Consortium</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O’Callaghan, Karen M.</au><au>Nowak, Katarzyna G.</au><au>Dalrymple, Kathryn V.</au><au>Poston, Lucilla</au><au>Rigutto-Farebrother, Jessica</au><au>Quotah, Ola F.</au><au>White, Sara L.</au><au>Flynn, Angela C.</au><aucorp>UPBEAT Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D status of pregnant women with obesity in the UK and its association with pregnancy outcomes: a secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT) study</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2024-07-14</date><risdate>2024</risdate><volume>132</volume><issue>1</issue><spage>40</spage><epage>49</epage><pages>40-49</pages><issn>0007-1145</issn><issn>1475-2662</issn><eissn>1475-2662</eissn><abstract>Prenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial, we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI ≥ 30 kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17 ± 1 weeks’ gestation were assessed using multivariable linear regression and reported as percent differences in serum 25-hydroxyvitamin D (25(OH)D). Associations between 25(OH)D and clinical outcomes were examined using logistic regression. Among 1089 participants, 67 % had 25(OH)D < 50 nmol/l and 26 % had concentrations < 25 nmol/l. In fully adjusted models accounting for socio-demographic and anthropometric characteristics, 25(OH)D was lower among women of Black (% difference = −33; 95 % CI: −39, −27), Asian (% difference = −43; 95 % CI: −51, −35) and other non-White (% difference = −26; 95 % CI: −35, −14) ethnicity compared with women of White ethnicity (n 1086; P < 0·001 for all). In unadjusted analysis, risk of gestational diabetes was greater in women with 25(OH)D < 25 nmol/l compared with ≥ 50 nmol/l (OR = 1·58; 95 % CI: 1·09, 2·31), but the magnitude of effect estimates was attenuated in the multivariable model (OR = 1·33; 95 % CI: 0·88, 2·00). There were no associations between 25(OH)D and risk of preeclampsia, preterm birth or small for gestational age or large-for-gestational-age delivery. These findings demonstrate low 25(OH)D among pregnant women with obesity and highlight ethnic disparities in vitamin D status in the UK. However, evidence for a greater risk of adverse perinatal outcomes among women with vitamin D deficiency was limited.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S0007114524000862</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5853-3796</orcidid><orcidid>https://orcid.org/0000-0003-0958-6725</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 25-Hydroxyvitamin D Automation Blood pressure Calciferol Diabetes Diabetes mellitus Eating Ethnicity Gestational age Glucose Human and Clinical Nutrition Immunoassay Minority & ethnic groups Obesity Overweight Pre-eclampsia Pregnancy Pregnancy complications Premature birth Public health Secondary analysis Small for gestational age Sociodemographics Vitamin D Vitamin deficiency Womens health |
title | Vitamin D status of pregnant women with obesity in the UK and its association with pregnancy outcomes: a secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT) study |
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