An unfavorable and a successful pregnancy outcome during and after treatment of gamma heavy chain disease
Gamma heavy chain disease (gHCD) is a rare B-cell lymphoproliferative disorder that mostly occurs after childbearing age. Here we report the first case of gHCD in a pregnant patient that was diagnosed in the second trimester, and another pregnancy in the same patient after initial treatment for gHCD...
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| Veröffentlicht in: | International journal of hematology 2024-07, Vol.120 (1), p.135-141 |
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| container_title | International journal of hematology |
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| creator | Hosoi, Masataka Ueno, Kazunori Kikuchi, Jun Miyauchi, Jun Ooka, Reina Takikawa, Kaito Arai, Yuya Kikuchi, Misato Watanabe, Takuro |
| description | Gamma heavy chain disease (gHCD) is a rare B-cell lymphoproliferative disorder that mostly occurs after childbearing age. Here we report the first case of gHCD in a pregnant patient that was diagnosed in the second trimester, and another pregnancy in the same patient after initial treatment for gHCD. The former pregnancy ended in intrauterine fetal death, believed to be caused by insufficient maternal blood flow due to multiple placental infarcts. The latter pregnancy course was uneventful. Although we cannot rule out the possibility that the poor outcome of the former pregnancy was due to an unfortunate complication independent of gHCD, the courses of these pregnancies suggest that non-lymphomatous gamma heavy chain may have a significant impact on pregnancy and that its removal by treatment may improve outcomes. |
| doi_str_mv | 10.1007/s12185-024-03769-1 |
| format | Article |
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| subjects | Antibodies Blood flow Case Report Case reports Cell death Diabetes Disease Fetuses Gestational age Gynecology Heavy chain disease Hematology Hemoglobin Hospitals Lupus Lymphocytes Lymphocytes B Medical imaging Medicine Medicine & Public Health Obstetrics Oncology Pleural effusion Pregnancy Pregnancy complications Remission (Medicine) Serology Thyroid gland Tomography |
| title | An unfavorable and a successful pregnancy outcome during and after treatment of gamma heavy chain disease |
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