Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions
A 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatm...
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| Veröffentlicht in: | Internal medicine (Tokyo, 1992) 1992), 2024-12, Vol.63 (24), p.3317-3323, Article 3412-23 |
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| creator | Harada, Takahito Hirata, Yoshikazu Kawamura, Hayato Yamamoto, Yuki Kobayashi, Yuka Kumai, Daisuke Adachi, Akihisa Nagura, Yoshihito Ikeuchi, Hirokazu Hayashi, Noriyuki Takada, Hiroki Sobue, Satoshi Yoshida, Megumi |
| description | A 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappearance of a skin rash confirmed an exacerbation of AOSD. Tocilizumab treatment alleviated the symptoms and improved the endoscopic findings. Considering their correlation with the symptoms and endoscopic findings, the observed gastrointestinal lesions may be linked to AOSD. |
| doi_str_mv | 10.2169/internalmedicine.3412-23 |
| format | Article |
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A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappearance of a skin rash confirmed an exacerbation of AOSD. Tocilizumab treatment alleviated the symptoms and improved the endoscopic findings. Considering their correlation with the symptoms and endoscopic findings, the observed gastrointestinal lesions may be linked to AOSD.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.3412-23</identifier><identifier>PMID: 38631856</identifier><language>eng</language><publisher>Japan: Japan Science and Technology Agency</publisher><subject>Antibodies, Monoclonal, Humanized - therapeutic use ; Case Report ; Colon ; Colonoscopy ; Computed tomography ; Cyclosporins ; Exanthema ; Female ; Fever ; Humans ; Ileum ; Juvenile rheumatoid arthritis ; Medical treatment ; Methylprednisolone ; Methylprednisolone - therapeutic use ; Middle Aged ; Pharyngitis ; Prednisolone ; Skin diseases ; Still's Disease, Adult-Onset - complications ; Still's Disease, Adult-Onset - diagnosis ; Still's Disease, Adult-Onset - drug therapy ; Tomography, X-Ray Computed</subject><ispartof>Internal medicine (Tokyo, 1992), 2024-12, Vol.63 (24), p.3317-3323, Article 3412-23</ispartof><rights>2024. 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A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappearance of a skin rash confirmed an exacerbation of AOSD. Tocilizumab treatment alleviated the symptoms and improved the endoscopic findings. Considering their correlation with the symptoms and endoscopic findings, the observed gastrointestinal lesions may be linked to AOSD.</description><subject>Antibodies, Monoclonal, Humanized - therapeutic use</subject><subject>Case Report</subject><subject>Colon</subject><subject>Colonoscopy</subject><subject>Computed tomography</subject><subject>Cyclosporins</subject><subject>Exanthema</subject><subject>Female</subject><subject>Fever</subject><subject>Humans</subject><subject>Ileum</subject><subject>Juvenile rheumatoid arthritis</subject><subject>Medical treatment</subject><subject>Methylprednisolone</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Middle Aged</subject><subject>Pharyngitis</subject><subject>Prednisolone</subject><subject>Skin diseases</subject><subject>Still's Disease, Adult-Onset - complications</subject><subject>Still's Disease, Adult-Onset - diagnosis</subject><subject>Still's Disease, Adult-Onset - drug therapy</subject><subject>Tomography, X-Ray Computed</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUT1PwzAUtBCIlsJfQJEYKEPAH7FjT1C1UJAqdSjMluM41FUalzgB8e9x1FJBF3t4d_fe3QEQIXiLERN3tmpMXalybXKrbWVuSYJwjMkR6COSiDjFhB6DPhSIxzg8PXDm_QpCwlOBT0GPcEYQp6wPHkZ5Wzaxq7xpokVjy_LaRxPrjfImGo7mi8lN9GWbZTRVvqldt9g3NqyOZsbbQDsHJ4UqvbnY_QPw9vT4On6OZ_Ppy3g0izXiIokxwxClSiBGoBaG0ySHRZLzLGWGMpoIhaFIGdUCs8Igk2RCZDmFTBc5JkyRAbjf6m7aLNjWpmpqVcpNbdeq_pZOWfl_UtmlfHefEqE0RJAmQWG4U6jdRxtsyLX12pSlqoxrvSQwhEggojRArw6gK9d2gQdUmFOMCeEBxbcoXTvva1Psr0FQdj3Jw55k15MM5AG4_OtmT_wthvwAm_aStQ</recordid><startdate>20241215</startdate><enddate>20241215</enddate><creator>Harada, Takahito</creator><creator>Hirata, Yoshikazu</creator><creator>Kawamura, Hayato</creator><creator>Yamamoto, Yuki</creator><creator>Kobayashi, Yuka</creator><creator>Kumai, Daisuke</creator><creator>Adachi, Akihisa</creator><creator>Nagura, Yoshihito</creator><creator>Ikeuchi, Hirokazu</creator><creator>Hayashi, Noriyuki</creator><creator>Takada, Hiroki</creator><creator>Sobue, Satoshi</creator><creator>Yoshida, Megumi</creator><general>Japan Science and Technology Agency</general><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241215</creationdate><title>Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions</title><author>Harada, Takahito ; 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| subjects | Antibodies, Monoclonal, Humanized - therapeutic use Case Report Colon Colonoscopy Computed tomography Cyclosporins Exanthema Female Fever Humans Ileum Juvenile rheumatoid arthritis Medical treatment Methylprednisolone Methylprednisolone - therapeutic use Middle Aged Pharyngitis Prednisolone Skin diseases Still's Disease, Adult-Onset - complications Still's Disease, Adult-Onset - diagnosis Still's Disease, Adult-Onset - drug therapy Tomography, X-Ray Computed |
| title | Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions |
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