Caveolin-2 palmitoylation turnover facilitates insulin receptor substrate-1-directed lipid metabolism by insulin receptor tyrosine kinase

Here, we show that insulin induces palmitoylation turnover of Caveolin-2 (Cav-2) in adipocytes. Acyl protein thioesterases-1 (APT1) catalyzes Cav-2 depalmitoylation, and zinc finger DHHC domain-containing protein palmitoyltransferase 21 (ZDHHC21) repalmitoylation of the depalmitoylated Cav-2 for the...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-06, Vol.1870 (5), p.167173, Article 167173
Hauptverfasser:	Choi, Moonjeong, Lee, Jaewoong, Jeong, Kyuho, Pak, Yunbae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocyte lipid metabolism APT1 Caveolin-2 Insulin receptor tyrosine kinase signaling Palmitoylation turnover ZDHHC21
Online-Zugang:	Volltext
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