Cationic nanoparticles-based approaches for immune tolerance induction in vivo
The development of autoimmune diseases and the rejection of transplanted organs are primarily caused by an exaggerated immune response to autoantigens or graft antigens. Achieving immune tolerance is crucial for the effective treatment of these conditions. However, traditional therapies often have l...
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| Veröffentlicht in: | Journal of controlled release 2024-02, Vol.366, p.425-447 |
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| creator | Mao, Kuirong Wang, Jialiang Xie, Qianyue Yang, Yong-Guang Shen, Song Sun, Tianmeng Wang, Jun |
| description | The development of autoimmune diseases and the rejection of transplanted organs are primarily caused by an exaggerated immune response to autoantigens or graft antigens. Achieving immune tolerance is crucial for the effective treatment of these conditions. However, traditional therapies often have limited therapeutic efficacy and can result in systemic toxic effects. The emergence of nanomedicine offers a promising avenue for addressing immune-related diseases. Among the various nanoparticle formulations, cationic nanoparticles have demonstrated significant potential in inducing immune tolerance. In this review, we provide an overview of the underlying mechanism of autoimmune disease and organ transplantation rejection. We then highlight the recent advancements and advantages of utilizing cationic nanoparticles for inducing immune tolerance in the treatment of autoimmune diseases and the prevention of transplant rejection.
[Display omitted]
•Important role of immunomodulation in autoimmune diseases and organ transplantation.•The great promises of cationic nanoparticles in inducing immune tolerance for related diseases therapy.•Illustration the design and optimization of cationic nanoparticles.•Advantages of cationic nanoparticles in modulating immune cell functions. |
| doi_str_mv | 10.1016/j.jconrel.2023.12.044 |
| format | Article |
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[Display omitted]
•Important role of immunomodulation in autoimmune diseases and organ transplantation.•The great promises of cationic nanoparticles in inducing immune tolerance for related diseases therapy.•Illustration the design and optimization of cationic nanoparticles.•Advantages of cationic nanoparticles in modulating immune cell functions.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2023.12.044</identifier><identifier>PMID: 38154540</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Autoantigens ; autoimmune diseases ; Autoimmune Diseases - therapy ; Autoimmunity ; Cationic nanoparticles ; Cations ; Drug delivery ; graft rejection ; Humans ; Immune Tolerance ; immunosuppression ; nanomedicine ; Nanoparticles ; organ transplantation ; toxicity ; Transplant rejection</subject><ispartof>Journal of controlled release, 2024-02, Vol.366, p.425-447</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c346t-6b731d9ea09265d79175e48541a49a8e2b1abdf46b1e57a01317548b9617a75c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365923008283$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38154540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mao, Kuirong</creatorcontrib><creatorcontrib>Wang, Jialiang</creatorcontrib><creatorcontrib>Xie, Qianyue</creatorcontrib><creatorcontrib>Yang, Yong-Guang</creatorcontrib><creatorcontrib>Shen, Song</creatorcontrib><creatorcontrib>Sun, Tianmeng</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><title>Cationic nanoparticles-based approaches for immune tolerance induction in vivo</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>The development of autoimmune diseases and the rejection of transplanted organs are primarily caused by an exaggerated immune response to autoantigens or graft antigens. Achieving immune tolerance is crucial for the effective treatment of these conditions. However, traditional therapies often have limited therapeutic efficacy and can result in systemic toxic effects. The emergence of nanomedicine offers a promising avenue for addressing immune-related diseases. Among the various nanoparticle formulations, cationic nanoparticles have demonstrated significant potential in inducing immune tolerance. In this review, we provide an overview of the underlying mechanism of autoimmune disease and organ transplantation rejection. We then highlight the recent advancements and advantages of utilizing cationic nanoparticles for inducing immune tolerance in the treatment of autoimmune diseases and the prevention of transplant rejection.
[Display omitted]
•Important role of immunomodulation in autoimmune diseases and organ transplantation.•The great promises of cationic nanoparticles in inducing immune tolerance for related diseases therapy.•Illustration the design and optimization of cationic nanoparticles.•Advantages of cationic nanoparticles in modulating immune cell functions.</description><subject>Autoantigens</subject><subject>autoimmune diseases</subject><subject>Autoimmune Diseases - therapy</subject><subject>Autoimmunity</subject><subject>Cationic nanoparticles</subject><subject>Cations</subject><subject>Drug delivery</subject><subject>graft rejection</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>immunosuppression</subject><subject>nanomedicine</subject><subject>Nanoparticles</subject><subject>organ transplantation</subject><subject>toxicity</subject><subject>Transplant rejection</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P4zAQhi3EipaPnwDKkUuyHn8k9gmhCpaVEFx2z5bjTIWrJC52Uol_v65a9trTzOF55x09hNwCrYBC_XNTbVwYI_YVo4xXwCoqxBlZgmp4KbSW52SZOVXyWuoFuUxpQymVXDQXZMEVSCEFXZK3lZ18GL0rRjuGrY2Tdz2msrUJu8JutzFY94GpWIdY-GGYRyym0GO0o8PCj93s9vm8FTu_C9fkx9r2CW-O84r8fX76s3opX99__V49vpaOi3oq67bh0Gm0VLNado2GRqJQUoAV2ipkLdi2W4u6BZSNpcAzIFSra2hsIx2_IveHu_m_zxnTZAafHPa9HTHMyXAqqFCMKTiJMk0VMKalzKg8oC6GlCKuzTb6wcYvA9TsrZuNOVo3e-sGmMnWc-7uWDG3A3b_U9-aM_BwADA72XmMJjmP2WDnI7rJdMGfqPgHQ8eVbA</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Mao, Kuirong</creator><creator>Wang, Jialiang</creator><creator>Xie, Qianyue</creator><creator>Yang, Yong-Guang</creator><creator>Shen, Song</creator><creator>Sun, Tianmeng</creator><creator>Wang, Jun</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202402</creationdate><title>Cationic nanoparticles-based approaches for immune tolerance induction in vivo</title><author>Mao, Kuirong ; Wang, Jialiang ; Xie, Qianyue ; Yang, Yong-Guang ; Shen, Song ; Sun, Tianmeng ; Wang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-6b731d9ea09265d79175e48541a49a8e2b1abdf46b1e57a01317548b9617a75c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Autoantigens</topic><topic>autoimmune diseases</topic><topic>Autoimmune Diseases - therapy</topic><topic>Autoimmunity</topic><topic>Cationic nanoparticles</topic><topic>Cations</topic><topic>Drug delivery</topic><topic>graft rejection</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>immunosuppression</topic><topic>nanomedicine</topic><topic>Nanoparticles</topic><topic>organ transplantation</topic><topic>toxicity</topic><topic>Transplant rejection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mao, Kuirong</creatorcontrib><creatorcontrib>Wang, Jialiang</creatorcontrib><creatorcontrib>Xie, Qianyue</creatorcontrib><creatorcontrib>Yang, Yong-Guang</creatorcontrib><creatorcontrib>Shen, Song</creatorcontrib><creatorcontrib>Sun, Tianmeng</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mao, Kuirong</au><au>Wang, Jialiang</au><au>Xie, Qianyue</au><au>Yang, Yong-Guang</au><au>Shen, Song</au><au>Sun, Tianmeng</au><au>Wang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cationic nanoparticles-based approaches for immune tolerance induction in vivo</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2024-02</date><risdate>2024</risdate><volume>366</volume><spage>425</spage><epage>447</epage><pages>425-447</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>The development of autoimmune diseases and the rejection of transplanted organs are primarily caused by an exaggerated immune response to autoantigens or graft antigens. 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[Display omitted]
•Important role of immunomodulation in autoimmune diseases and organ transplantation.•The great promises of cationic nanoparticles in inducing immune tolerance for related diseases therapy.•Illustration the design and optimization of cationic nanoparticles.•Advantages of cationic nanoparticles in modulating immune cell functions.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38154540</pmid><doi>10.1016/j.jconrel.2023.12.044</doi><tpages>23</tpages></addata></record> |
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| ispartof | Journal of controlled release, 2024-02, Vol.366, p.425-447 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Autoantigens autoimmune diseases Autoimmune Diseases - therapy Autoimmunity Cationic nanoparticles Cations Drug delivery graft rejection Humans Immune Tolerance immunosuppression nanomedicine Nanoparticles organ transplantation toxicity Transplant rejection |
| title | Cationic nanoparticles-based approaches for immune tolerance induction in vivo |
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