Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae
Two new isocoumarins, 5-(2-hydroxyethyl)-7-methoxy-3-(2-oxopropyl)-1H-isocoumarin ( 1 ), 7-methoxy-5-methyl-3-(2-oxopropyl)-1H-isocoumarin ( 2 ), along with four known ones, were isolated from the fermentation products of an endophytic fungus Aspergillus oryzae derived from cigar tobacco. Their stru...
Gespeichert in:
| Veröffentlicht in: | Chemistry of natural compounds 2023-03, Vol.59 (2), p.242-245 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 245 |
|---|---|
| container_issue | 2 |
| container_start_page | 242 |
| container_title | Chemistry of natural compounds |
| container_volume | 59 |
| creator | Kong, Guang-Hui Gu, Xue-Jiao Wu, Jing Zheng, Jun-Na Huang, De-Quan Zhang, Guang-Hai Bao, Mei-Fen Hu, Qiu-Fen Wu, Yu-Ping Li, Yin-Ke |
| description | Two new isocoumarins, 5-(2-hydroxyethyl)-7-methoxy-3-(2-oxopropyl)-1H-isocoumarin (
1
), 7-methoxy-5-methyl-3-(2-oxopropyl)-1H-isocoumarin (
2
), along with four known ones, were isolated from the fermentation products of an endophytic fungus
Aspergillus oryzae
derived from cigar tobacco. Their structures were elucidated by spectroscopic methods. Compounds
1
and
2
exhibited anti-TMV activities with inhibition rates of 36.2 and 32.8% at a concentration of 20 μmol/mL, respectively, compared with 35.6% for positive control ningnanmycin. |
| doi_str_mv | 10.1007/s10600-023-03966-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_3040454588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A751383084</galeid><sourcerecordid>A751383084</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-12deefc0b03f9cb5bb84c60d5ad6faa44288ebc1b0c04119ee59b6f7628da7dd3</originalsourceid><addsrcrecordid>eNp9kcGKFDEQhoMoOK6-gKcGL3rIWumk0-njMO7qwIKgK3gL6aTSZunpjEn34vj0ZhxhGRHJIanw_UUVHyEvGVwygPZtZiABKNScAu-kpPCIrFjTcqq4Uo_JCgA6yhmHp-RZznelVFKqFfm6nuZwH5IZq22ONi47k8KUK5_irjLVJgwmVbexN9ZG-g5TuEdXXU0u7r8d5mCr62Uallyt8x7TEMaxvGM6_DT4nDzxZsz44s99Qb5cX91uPtCbj--3m_UNtaLhM2W1Q_QWeuC-s33T90pYCa4xTnpjhKiVwt6yHiwIxjrEpuulb2WtnGmd4xfk9anvPsXvC-ZZ70K2OI5mwrhkzUGAaESjVEFf_YXexSVNZTpdq5rxVkgFD9RgRtRh8nFOxh6b6nXbMK44KFGoy39Q5TjcBRsn9KH8nwXenAUKM-OPeTBLznr7-dM5W59Ym2LOCb3ep1DEHDQDffStT7518a1_-9bHufkplAs8DZgetvtP6heBmKvv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821374680</pqid></control><display><type>article</type><title>Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae</title><source>SpringerLink Journals</source><creator>Kong, Guang-Hui ; Gu, Xue-Jiao ; Wu, Jing ; Zheng, Jun-Na ; Huang, De-Quan ; Zhang, Guang-Hai ; Bao, Mei-Fen ; Hu, Qiu-Fen ; Wu, Yu-Ping ; Li, Yin-Ke</creator><creatorcontrib>Kong, Guang-Hui ; Gu, Xue-Jiao ; Wu, Jing ; Zheng, Jun-Na ; Huang, De-Quan ; Zhang, Guang-Hai ; Bao, Mei-Fen ; Hu, Qiu-Fen ; Wu, Yu-Ping ; Li, Yin-Ke</creatorcontrib><description>Two new isocoumarins, 5-(2-hydroxyethyl)-7-methoxy-3-(2-oxopropyl)-1H-isocoumarin (
1
), 7-methoxy-5-methyl-3-(2-oxopropyl)-1H-isocoumarin (
2
), along with four known ones, were isolated from the fermentation products of an endophytic fungus
Aspergillus oryzae
derived from cigar tobacco. Their structures were elucidated by spectroscopic methods. Compounds
1
and
2
exhibited anti-TMV activities with inhibition rates of 36.2 and 32.8% at a concentration of 20 μmol/mL, respectively, compared with 35.6% for positive control ningnanmycin.</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-023-03966-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antiviral agents ; Aspergillus oryzae ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; endophytes ; fermentation ; Fungi ; isocoumarins ; Organic Chemistry ; Plant Sciences ; spectroscopy ; Tobacco</subject><ispartof>Chemistry of natural compounds, 2023-03, Vol.59 (2), p.242-245</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-12deefc0b03f9cb5bb84c60d5ad6faa44288ebc1b0c04119ee59b6f7628da7dd3</citedby><cites>FETCH-LOGICAL-c453t-12deefc0b03f9cb5bb84c60d5ad6faa44288ebc1b0c04119ee59b6f7628da7dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10600-023-03966-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10600-023-03966-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Kong, Guang-Hui</creatorcontrib><creatorcontrib>Gu, Xue-Jiao</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Zheng, Jun-Na</creatorcontrib><creatorcontrib>Huang, De-Quan</creatorcontrib><creatorcontrib>Zhang, Guang-Hai</creatorcontrib><creatorcontrib>Bao, Mei-Fen</creatorcontrib><creatorcontrib>Hu, Qiu-Fen</creatorcontrib><creatorcontrib>Wu, Yu-Ping</creatorcontrib><creatorcontrib>Li, Yin-Ke</creatorcontrib><title>Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>Two new isocoumarins, 5-(2-hydroxyethyl)-7-methoxy-3-(2-oxopropyl)-1H-isocoumarin (
1
), 7-methoxy-5-methyl-3-(2-oxopropyl)-1H-isocoumarin (
2
), along with four known ones, were isolated from the fermentation products of an endophytic fungus
Aspergillus oryzae
derived from cigar tobacco. Their structures were elucidated by spectroscopic methods. Compounds
1
and
2
exhibited anti-TMV activities with inhibition rates of 36.2 and 32.8% at a concentration of 20 μmol/mL, respectively, compared with 35.6% for positive control ningnanmycin.</description><subject>Antiviral agents</subject><subject>Aspergillus oryzae</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>endophytes</subject><subject>fermentation</subject><subject>Fungi</subject><subject>isocoumarins</subject><subject>Organic Chemistry</subject><subject>Plant Sciences</subject><subject>spectroscopy</subject><subject>Tobacco</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kcGKFDEQhoMoOK6-gKcGL3rIWumk0-njMO7qwIKgK3gL6aTSZunpjEn34vj0ZhxhGRHJIanw_UUVHyEvGVwygPZtZiABKNScAu-kpPCIrFjTcqq4Uo_JCgA6yhmHp-RZznelVFKqFfm6nuZwH5IZq22ONi47k8KUK5_irjLVJgwmVbexN9ZG-g5TuEdXXU0u7r8d5mCr62Uallyt8x7TEMaxvGM6_DT4nDzxZsz44s99Qb5cX91uPtCbj--3m_UNtaLhM2W1Q_QWeuC-s33T90pYCa4xTnpjhKiVwt6yHiwIxjrEpuulb2WtnGmd4xfk9anvPsXvC-ZZ70K2OI5mwrhkzUGAaESjVEFf_YXexSVNZTpdq5rxVkgFD9RgRtRh8nFOxh6b6nXbMK44KFGoy39Q5TjcBRsn9KH8nwXenAUKM-OPeTBLznr7-dM5W59Ym2LOCb3ep1DEHDQDffStT7518a1_-9bHufkplAs8DZgetvtP6heBmKvv</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Kong, Guang-Hui</creator><creator>Gu, Xue-Jiao</creator><creator>Wu, Jing</creator><creator>Zheng, Jun-Na</creator><creator>Huang, De-Quan</creator><creator>Zhang, Guang-Hai</creator><creator>Bao, Mei-Fen</creator><creator>Hu, Qiu-Fen</creator><creator>Wu, Yu-Ping</creator><creator>Li, Yin-Ke</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20230301</creationdate><title>Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae</title><author>Kong, Guang-Hui ; Gu, Xue-Jiao ; Wu, Jing ; Zheng, Jun-Na ; Huang, De-Quan ; Zhang, Guang-Hai ; Bao, Mei-Fen ; Hu, Qiu-Fen ; Wu, Yu-Ping ; Li, Yin-Ke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-12deefc0b03f9cb5bb84c60d5ad6faa44288ebc1b0c04119ee59b6f7628da7dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antiviral agents</topic><topic>Aspergillus oryzae</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>endophytes</topic><topic>fermentation</topic><topic>Fungi</topic><topic>isocoumarins</topic><topic>Organic Chemistry</topic><topic>Plant Sciences</topic><topic>spectroscopy</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Guang-Hui</creatorcontrib><creatorcontrib>Gu, Xue-Jiao</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Zheng, Jun-Na</creatorcontrib><creatorcontrib>Huang, De-Quan</creatorcontrib><creatorcontrib>Zhang, Guang-Hai</creatorcontrib><creatorcontrib>Bao, Mei-Fen</creatorcontrib><creatorcontrib>Hu, Qiu-Fen</creatorcontrib><creatorcontrib>Wu, Yu-Ping</creatorcontrib><creatorcontrib>Li, Yin-Ke</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Guang-Hui</au><au>Gu, Xue-Jiao</au><au>Wu, Jing</au><au>Zheng, Jun-Na</au><au>Huang, De-Quan</au><au>Zhang, Guang-Hai</au><au>Bao, Mei-Fen</au><au>Hu, Qiu-Fen</au><au>Wu, Yu-Ping</au><au>Li, Yin-Ke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2023-03-01</date><risdate>2023</risdate><volume>59</volume><issue>2</issue><spage>242</spage><epage>245</epage><pages>242-245</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>Two new isocoumarins, 5-(2-hydroxyethyl)-7-methoxy-3-(2-oxopropyl)-1H-isocoumarin (
1
), 7-methoxy-5-methyl-3-(2-oxopropyl)-1H-isocoumarin (
2
), along with four known ones, were isolated from the fermentation products of an endophytic fungus
Aspergillus oryzae
derived from cigar tobacco. Their structures were elucidated by spectroscopic methods. Compounds
1
and
2
exhibited anti-TMV activities with inhibition rates of 36.2 and 32.8% at a concentration of 20 μmol/mL, respectively, compared with 35.6% for positive control ningnanmycin.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10600-023-03966-0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-3130 |
| ispartof | Chemistry of natural compounds, 2023-03, Vol.59 (2), p.242-245 |
| issn | 0009-3130 1573-8388 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3040454588 |
| source | SpringerLink Journals |
| subjects | Antiviral agents Aspergillus oryzae Chemistry Chemistry and Materials Science Chemistry/Food Science endophytes fermentation Fungi isocoumarins Organic Chemistry Plant Sciences spectroscopy Tobacco |
| title | Antiviral Isocoumarins from a Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T15%3A00%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antiviral%20Isocoumarins%20from%20a%20Cigar%20Tobacco-Derived%20Endophytic%20Fungus%20Aspergillus%20oryzae&rft.jtitle=Chemistry%20of%20natural%20compounds&rft.au=Kong,%20Guang-Hui&rft.date=2023-03-01&rft.volume=59&rft.issue=2&rft.spage=242&rft.epage=245&rft.pages=242-245&rft.issn=0009-3130&rft.eissn=1573-8388&rft_id=info:doi/10.1007/s10600-023-03966-0&rft_dat=%3Cgale_proqu%3EA751383084%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2821374680&rft_id=info:pmid/&rft_galeid=A751383084&rfr_iscdi=true |