Update of the Cancer Potency Database (CPDB) to enable derivations of Thresholds of Toxicological Concern (TTC) for cancer potency
The purpose of this study was to update the existing Cancer Potency Database (CPDB) in order to support the development of a dataset of compounds, with associated points of departure (PoDs), to enable a review and update of currently applied values for the Threshold of Toxicological Concern (TTC) fo...
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| Veröffentlicht in: | Food and chemical toxicology 2023-12, Vol.182, p.114182-114182, Article 114182 |
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| container_title | Food and chemical toxicology |
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| creator | Yang, Chihae Rathman, James F Ribeiro, J Vinicius Batke, Monika Escher, Sylvia E Firman, James W Hobocienski, Bryan Kellner, Rupert Mostrag, Aleksandra Przybylak, Katarzyna R Cronin, Mark T D |
| description | The purpose of this study was to update the existing Cancer Potency Database (CPDB) in order to support the development of a dataset of compounds, with associated points of departure (PoDs), to enable a review and update of currently applied values for the Threshold of Toxicological Concern (TTC) for cancer endpoints. This update of the current CPDB, last reviewed in 2012, includes the addition of new data (44 compounds and 158 studies leading to additional 359 dose-response curves). Strict inclusion criteria were established and applied to select compounds and studies with relevant cancer potency data. PoDs were calculated from dose-response modeling, including the benchmark dose (BMD) and the lower 90% confidence limits (BMDL) at a specified benchmark response (BMR) of 10%. The updated full CPDB database resulted in a total of 421 chemicals which had dose-response data that could be used to calculate PoDs. This candidate dataset for cancer TTC is provided in a transparent and adaptable format for further analysis of TTC to derive cancer potency thresholds. |
| doi_str_mv | 10.1016/j.fct.2023.114182 |
| format | Article |
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This update of the current CPDB, last reviewed in 2012, includes the addition of new data (44 compounds and 158 studies leading to additional 359 dose-response curves). Strict inclusion criteria were established and applied to select compounds and studies with relevant cancer potency data. PoDs were calculated from dose-response modeling, including the benchmark dose (BMD) and the lower 90% confidence limits (BMDL) at a specified benchmark response (BMR) of 10%. The updated full CPDB database resulted in a total of 421 chemicals which had dose-response data that could be used to calculate PoDs. 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| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2023-12, Vol.182, p.114182-114182, Article 114182 |
| issn | 0278-6915 1873-6351 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | data collection Databases, Factual dose response Humans Neoplasms - drug therapy Risk Assessment toxicology |
| title | Update of the Cancer Potency Database (CPDB) to enable derivations of Thresholds of Toxicological Concern (TTC) for cancer potency |
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