Cryopreserved red blood cells maintain allosteric control of oxygen binding when utilizing trehalose as a cryoprotectant

One of the most common life-saving medical procedures is a red blood cell (RBC) transfusion. Unfortunately, RBCs for transfusion have a limited shelf life after donation due to detrimental storage effects on their morphological and biochemical properties. Inspired by nature, a biomimetics approach w...

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Veröffentlicht in:	Cryobiology 2024-03, Vol.114, p.104793-104793, Article 104793
Hauptverfasser:	Elder, Charles A., Smith, Jensen S., Almosawi, Mustafa, Mills, Ethan, Janis, Brett R., Kopechek, Jonathan A., Wolkers, Willem F., Menze, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-BPG Animals biomimetics Blood Preservation - methods cooling cryobiology cryopreservation Cryopreservation - methods cryoprotectants Cryoprotective Agents - chemistry erythrocytes Erythrocytes - metabolism glycerol Glycerol - metabolism Glycerol - pharmacology Hemoglobin Hemoglobins - metabolism Hemoglobins - pharmacology Hemolysis Hill coefficient liquid nitrogen Non-reducing sugar oxygen Oxygen - metabolism Preservation shelf life storage time Swine trehalose Trehalose - metabolism Trehalose - pharmacology
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