Structural and computational insights into the regioselectivity of SpnK involved in rhamnose methylation of spinosyn

Rhamnose methylation of spinosyn critical for insecticidal activity is orchestrated by substrate specificity of three S-adenosyl-L-methionine (SAM) dependent methyltransferases (MTs). Previous in vitro enzymatic assays indicate that 3'-O-MT SpnK accepts the rhamnosylated aglycone (RAGL) and 2&#...

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Veröffentlicht in:	International journal of biological macromolecules 2023-12, Vol.253, p.126763-126763, Article 126763
Hauptverfasser:	Huang, Shuxin, Ji, Huining, Zheng, Jianting
Format:	Artikel
Sprache:	eng
Schlagworte:	hydrogen bonding insecticidal properties methylation methyltransferases moieties regioselectivity rhamnose S-adenosylmethionine substrate specificity
Online-Zugang:	Volltext
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