Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma
Hemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adu...
Gespeichert in:
| Veröffentlicht in: | Leukemia research reports 2024, Vol.21, p.100394-100394 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Report |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 100394 |
|---|---|
| container_issue | |
| container_start_page | 100394 |
| container_title | Leukemia research reports |
| container_volume | 21 |
| creator | Samar, Mirza Rameez Shoaib, Daania E Zehra, Nida Moosajee, Munira |
| description | Hemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH have been brought to light. |
| doi_str_mv | 10.1016/j.lrr.2023.100394 |
| format | Report |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_3040323275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3040323275</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_30403232753</originalsourceid><addsrcrecordid>eNqVij1vwjAURS1UJKLCD2Dz1i5J_UUhc1WUgZGpC7KCSV5q5wU_JxL_vlRi6Nq73HuuDmNrKQop5PtbV_gYCyWUvrPQpZmxTCmpc2F25dOfvWArok7cUxq5UduMfR1scjn25BLf2wAerOeVCzi0tsH6lqDmh1sYWmyBEvw-SEAcem45jXGCCSPHC6_w3HxD_0IPPdglm1-sJ7d69DN73X8eP6p8iHgdHaVTAKqd97Z3ONJJCyO00mq70f9QfwDCDE8L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype><pqid>3040323275</pqid></control><display><type>report</type><title>Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Samar, Mirza Rameez ; Shoaib, Daania ; E Zehra, Nida ; Moosajee, Munira</creator><creatorcontrib>Samar, Mirza Rameez ; Shoaib, Daania ; E Zehra, Nida ; Moosajee, Munira</creatorcontrib><description>Hemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH have been brought to light.</description><identifier>ISSN: 2213-0489</identifier><identifier>EISSN: 2213-0489</identifier><identifier>DOI: 10.1016/j.lrr.2023.100394</identifier><language>eng</language><ispartof>Leukemia research reports, 2024, Vol.21, p.100394-100394</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>777,781,861,4476,27906</link.rule.ids></links><search><creatorcontrib>Samar, Mirza Rameez</creatorcontrib><creatorcontrib>Shoaib, Daania</creatorcontrib><creatorcontrib>E Zehra, Nida</creatorcontrib><creatorcontrib>Moosajee, Munira</creatorcontrib><title>Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma</title><title>Leukemia research reports</title><description>Hemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH have been brought to light.</description><issn>2213-0489</issn><issn>2213-0489</issn><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2024</creationdate><recordtype>report</recordtype><recordid>eNqVij1vwjAURS1UJKLCD2Dz1i5J_UUhc1WUgZGpC7KCSV5q5wU_JxL_vlRi6Nq73HuuDmNrKQop5PtbV_gYCyWUvrPQpZmxTCmpc2F25dOfvWArok7cUxq5UduMfR1scjn25BLf2wAerOeVCzi0tsH6lqDmh1sYWmyBEvw-SEAcem45jXGCCSPHC6_w3HxD_0IPPdglm1-sJ7d69DN73X8eP6p8iHgdHaVTAKqd97Z3ONJJCyO00mq70f9QfwDCDE8L</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Samar, Mirza Rameez</creator><creator>Shoaib, Daania</creator><creator>E Zehra, Nida</creator><creator>Moosajee, Munira</creator><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma</title><author>Samar, Mirza Rameez ; Shoaib, Daania ; E Zehra, Nida ; Moosajee, Munira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_30403232753</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Samar, Mirza Rameez</creatorcontrib><creatorcontrib>Shoaib, Daania</creatorcontrib><creatorcontrib>E Zehra, Nida</creatorcontrib><creatorcontrib>Moosajee, Munira</creatorcontrib><collection>MEDLINE - Academic</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samar, Mirza Rameez</au><au>Shoaib, Daania</au><au>E Zehra, Nida</au><au>Moosajee, Munira</au><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><atitle>Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma</atitle><jtitle>Leukemia research reports</jtitle><date>2024-01-01</date><risdate>2024</risdate><volume>21</volume><spage>100394</spage><epage>100394</epage><pages>100394-100394</pages><issn>2213-0489</issn><eissn>2213-0489</eissn><abstract>Hemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin. To date, only few cases of adult-onset familial HLH have been brought to light.</abstract><doi>10.1016/j.lrr.2023.100394</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2213-0489 |
| ispartof | Leukemia research reports, 2024, Vol.21, p.100394-100394 |
| issn | 2213-0489 2213-0489 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3040323275 |
| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T22%3A38%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.atitle=Late-onset%20Familial%20Hemophagocytic%20Lymphohistiocytosis%20in%20a%20survivor%20of%20Hodgkin's%20Lymphoma&rft.jtitle=Leukemia%20research%20reports&rft.au=Samar,%20Mirza%20Rameez&rft.date=2024-01-01&rft.volume=21&rft.spage=100394&rft.epage=100394&rft.pages=100394-100394&rft.issn=2213-0489&rft.eissn=2213-0489&rft_id=info:doi/10.1016/j.lrr.2023.100394&rft_dat=%3Cproquest%3E3040323275%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3040323275&rft_id=info:pmid/&rfr_iscdi=true |