Dual site reactivity of indole-3-Schiff bases with S/Se/Cl substituted ketenes for stereoselective C-4 substituted indole-β-lactams, biological evaluations, magic chloro effect and molecular docking studies

[Display omitted] •Dual reactivity of indoles-Schiff bases towards S/Se/Cl substituted ketenes.•Novel hybrids of S/Se/Cl-indole-β-lactams.•trans-Stereochemistry was established based on SC-XRD analyses.•5a and 5b with Cl substitutions suppress Gram +ve and -ve bacterial strain addressing “magic chlo...

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