Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling

In this study, a new series of Isoxazole-carboxamide derivatives were synthesized and characterized via HRMS, 1H-, 13CAPT-NMR, and MicroED. The findings revealed that nearly all of the synthesized derivatives exhibited potent inhibitory activities against both COX enzymes, with IC50 values ranging f...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-05, Vol.271, p.116397-116397, Article 116397
Hauptverfasser:	Hawash, Mohammed, Abdallah, Samer, Abudayyak, Mahmoud, Melhem, Yarob, Abu Shamat, Mohammed, Aghbar, Meera, Çapan, Irfan, Abualhasan, Murad, Kumar, Anil, Kamiński, Michał, Góral, Tomasz, Dominiak, Paulina Maria, Sobuh, Shorooq
Format:	Artikel
Sprache:	eng
Schlagworte:	3D multicellular spheroids Apoptosis Cancer COX HeLa Isoxazole MircoED
Online-Zugang:	Volltext
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