Protein Tyrosine Amination: Detection, Imaging, and Chemoproteomic Profiling with Synthetic Probes

Protein tyrosine nitration (PTN) by oxidative and nitrative stress is a well-known post-translational modification that plays a role in the initiation and progression of various diseases. Despite being recognized as a stable modification for decades, recent studies have suggested the existence of a...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-05, Vol.146 (17), p.11944-11954
Hauptverfasser:	Chen, Lei, Yang, Tonghua, Sun, Xue, Wong, Catherine C.L., Yang, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemical synthesis Aldehydes - chemistry Amination Animals Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Humans Mice Proteins - analysis Proteins - chemistry Proteins - metabolism Proteomics - methods Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - metabolism
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